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Umeclidinium / vilanterol Disease Interactions

There are 2 disease interactions with umeclidinium / vilanterol:


Inhaled anticholinergic bronchodilators (Includes umeclidinium/vilanterol) ↔ milk protein allergies

Severe Potential Hazard, Moderate plausibility. Applies to: Lactose Intolerance

Some inhaled anticholinergic bronchodilators such as aclidinium and umeclidinium are contraindicated in patients with severe hypersensitivity to milk proteins. There have been reports of anaphylactic reactions on these patients after inhalation of other powder products containing lactose, therefore patients with severe milk protein allergy should not use these products.


Umeclidinium (Includes umeclidinium/vilanterol) ↔ severe liver impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

Patients with moderate hepatic impairment showed no relevant increases in Cmax or AUC when using umeclidinium, when compared with healthy subjects. However, studies have not been performed in patients with severe hepatic impairment.

Umeclidinium / vilanterol drug interactions

There are 927 drug interactions with umeclidinium / vilanterol

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.