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Detrol (tolterodine) Disease Interactions

There are 3 disease interactions with Detrol (tolterodine):


Tolterodine (Includes Detrol) ↔ CNS

Moderate Potential Hazard, Moderate plausibility. Applies to: Dementia, CNS Disorder

Tolterodine is associated with anticholinergic central nervous system (CNS) effects. If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered. Tolterodine should be used with caution in patients with Parkinson's disease and in patients with preexisting dementia treated with cholinesterase inhibitors due to the risk of aggravation of symptoms.


Tolterodine (Includes Detrol) ↔ myasthenia gravis

Moderate Potential Hazard, Moderate plausibility. Applies to: Myasthenia Gravis

Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Caution is recommended when using this agent in patients with myasthenia gravis, a disease characterized by decreased cholinergic activity at the neuromuscular junction.


Tolterodine (Includes Detrol) ↔ QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applies to: Long QT Syndrome

Tolterodine has been associated with QT prolongation. The effect on QT interval correlates with plasma concentration of tolterodine. Caution is recommended when prescribing this agent to patients with a known history of QT prolongation or to patients who are taking Class IA (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications.

Detrol (tolterodine) drug interactions

There are 290 drug interactions with Detrol (tolterodine)

Detrol (tolterodine) alcohol/food interactions

There is 1 alcohol/food interaction with Detrol (tolterodine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.