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Zanosar (streptozocin) Disease Interactions

There are 2 disease interactions with Zanosar (streptozocin):

Major

Streptozocin (Includes Zanosar) ↔ Hepatic Dysfunction

Severe Potential Hazard, Low plausibility

Applies to: Liver Disease

Unspecified hepatic dysfunction has been noted during streptozocin therapy. The pharmacokinetic disposition of streptozocin has not been extensively studied. Therapy with streptozocin should be administered cautiously in patients with a history or predisposition to compromised hepatic function. Liver function tests should be done at least weekly and dosage adjustments or discontinuance of therapy may be indicated, depending upon the degree of toxicity noted.

References

  1. "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn, Kalamazoo, MI.
Moderate

Streptozocin (Includes Zanosar) ↔ Diabetes

Moderate Potential Hazard, Moderate plausibility

Applies to: Diabetes Mellitus

Mild to moderate abnormalities of glucose tolerance have been noted in some patients treated with streptozocin. These have generally been reversible, but insulin shock with hypoglycemia has been observed. Caution is recommended when using this agent in diabetic patients, and close monitoring of blood sugar levels is recommended during therapy.

Zanosar (streptozocin) drug Interactions

There are 213 drug interactions with Zanosar (streptozocin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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