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Zanosar Side Effects

Generic Name: streptozocin

Note: This document contains side effect information about streptozocin. Some of the dosage forms listed on this page may not apply to the brand name Zanosar.

For the Consumer

Applies to streptozocin: intravenous powder for solution

Along with their needed effects, medicines like streptozocin (the active ingredient contained in Zanosar) can sometimes cause unwanted effects such as kidney problems and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Streptozocin has been shown to cause tumors (some cancerous) in animals. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking streptozocin:

Less Common

  • Anxiety, nervousness, or shakiness
  • chills, cold sweats, or cool, pale skin
  • drowsiness or unusual tiredness or weakness
  • fast pulse
  • headache
  • pain or redness at place of injection
  • unusual hunger

Check with your doctor immediately if any of the following side effects occur while taking streptozocin:

Rare

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • unusual bleeding or bruising

Check with your doctor as soon as possible if any of the following side effects occur while taking streptozocin:

More Common

  • Swelling of feet or lower legs
  • unusual decrease in urination

Some side effects of streptozocin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Nausea and vomiting (usually occurs within 2 to 4 hours after receiving dose and may be severe)

Less Common

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

More Common

  • Decrease in urination
  • swelling of feet or lower legs

For Healthcare Professionals

Applies to streptozocin: intravenous powder for injection

Renal

Frequency not reported: Renal toxicity (azotemia, anuria, hypophosphatemia, glycosuria, renal tubular acidosis), nephrogenic diabetes insipidus[Ref]

Hepatic

Frequency not reported: Hepatic toxicity (elevated SGOT and LDH levels, hypoalbuminemia)[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea[Ref]

Hematologic

Rare (less than 0.1%): Hematologic toxicity (decreased hematocrit values, reduced leukocyte and platelet count)[Ref]

Metabolic

Frequency not reported: Glucose tolerance abnormalities, insulin shock, hypoglycemia[Ref]

Local

Postmarketing reports: Local inflammation[Ref]

Psychiatric

Frequency not reported: Confusion, lethargy, depression[Ref]

References

1. "Product Information. Zanosar (streptozocin)." Pharmacia and Upjohn, Kalamazoo, MI.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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