Rosuvastatin Disease Interactions
There are 5 disease interactions with rosuvastatin.
HMG-CoA reductase inhibitors (applies to rosuvastatin) cognitive impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: CNS Disorder
Cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) have been observed in patients receiving statins. The reports are usually not serious, and reversible upon statin discontinuation. Caution is recommended when using these agents in patients with cognitive impairment.
References (7)
- (2002) "Product Information. Mevacor (lovastatin)." Merck & Co., Inc
- (2001) "Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb
- (2001) "Product Information. Zocor (simvastatin)." Merck & Co., Inc
- (2001) "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals
- (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
- (2024) "Product Information. Lipitor (atorvastatin)." Viatris Specialty LLC, SUPPL-81
- (2024) "Product Information. Atorvaliq (atorvastatin)." Carolina Medical Products Company, SUPPL-2
HMG-CoA reductase inhibitors (applies to rosuvastatin) diabetes
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus
Increases in hemoglobin A1c and fasting serum glucose levels have been reported with the use of certain HMG-CoA reductase inhibitors. Caution should be exercised when using these agents in diabetic patients and close monitoring is recommended.
References (8)
- (2002) "Product Information. Mevacor (lovastatin)." Merck & Co., Inc
- (2001) "Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb
- (2001) "Product Information. Zocor (simvastatin)." Merck & Co., Inc
- (2001) "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals
- (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
- (2010) "Product Information. Livalo (pitavastatin)." Kowa Pharmaceuticals America (formerly ProEthic)
- (2024) "Product Information. Lipitor (atorvastatin)." Viatris Specialty LLC, SUPPL-81
- (2024) "Product Information. Atorvaliq (atorvastatin)." Carolina Medical Products Company, SUPPL-2
HMG-CoA reductase inhibitors (applies to rosuvastatin) renal disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Some HMG-CoA reductase inhibitors (e.g., fluvastatin) have not been studied in patients with severe renal dysfunction or end-stage renal disease. Some others (e.g., pitavastatin, simvastatin) require a dose reduction when used in this group of patients. Caution and close monitoring are advised when using these drugs in patients with renal dysfunction.
References (8)
- (2002) "Product Information. Mevacor (lovastatin)." Merck & Co., Inc
- (2001) "Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb
- (2001) "Product Information. Zocor (simvastatin)." Merck & Co., Inc
- (2001) "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals
- (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
- (2010) "Product Information. Livalo (pitavastatin)." Kowa Pharmaceuticals America (formerly ProEthic)
- (2024) "Product Information. Lipitor (atorvastatin)." Viatris Specialty LLC, SUPPL-81
- (2024) "Product Information. Atorvaliq (atorvastatin)." Carolina Medical Products Company, SUPPL-2
HMG-CoA reductase inhibitors (applies to rosuvastatin) rhabdomyolysis
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Myopathy, Myoneural Disorder, Hypothyroidism, Renal Dysfunction
HMG-CoA reductase inhibitors may cause myopathy and rhabdomyolysis; acute renal failure secondary to myoglobinuria and rare fatalities have occurred due to rhabdomyolysis in patients treated with statins. The myopathy may be dose-related and is characterized by unexplained muscle weakness, pain, or tenderness accompanied by increases in creatine phosphokinase (CPK) values exceeding 10 times the upper limit of normal. Therapy with HMG-CoA reductase inhibitors should be administered cautiously in patients with preexisting myopathy, in those with predisposing factors for myopathy, or with a history of myoneural disorder, since it may delay the recognition or confound the diagnosis of a drug-induced musculoskeletal effect. Patients should be advised to report promptly any unusual muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Periodic CPK determinations may be considered in some patients, although the value of such monitoring is uncertain. HMG-CoA reductase inhibitor therapy should be withdrawn if markedly elevated CPK levels occur or if drug-related myopathy is diagnosed or suspected.
References (9)
- (2002) "Product Information. Mevacor (lovastatin)." Merck & Co., Inc
- (2001) "Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb
- (2001) "Product Information. Zocor (simvastatin)." Merck & Co., Inc
- (2001) "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals
- (2001) "Product Information. Baycol (cerivastatin)." Bayer
- (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
- (2010) "Product Information. Livalo (pitavastatin)." Kowa Pharmaceuticals America (formerly ProEthic)
- (2024) "Product Information. Lipitor (atorvastatin)." Viatris Specialty LLC, SUPPL-81
- (2024) "Product Information. Atorvaliq (atorvastatin)." Carolina Medical Products Company, SUPPL-2
Rosuvastatin (applies to rosuvastatin) hematuria/proteinuria
Moderate Potential Hazard, Moderate plausibility.
An association between rosuvastatin and the development of proteinuria and microscopic hematuria was observed among treated patients during clinical trials. Patients with unexplained persistent proteinuria and/or hematuria during routine urinalysis testing should be instructed to reduce the dose of rosuvastatin according to clinical standards. Therapy with rosuvastatin should be administered cautiously in patients showing abnormal urinalysis. Monitoring for proteinuria and hematuria is recommended.
References (1)
- (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
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Rosuvastatin drug interactions
There are 247 drug interactions with rosuvastatin.
Rosuvastatin alcohol/food interactions
There is 1 alcohol/food interaction with rosuvastatin.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Crestor
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Zetia
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Zocor
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Mevacor
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Niacin
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Lovastatin
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Simvastatin
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Further information
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