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Bactroban (mupirocin topical) Disease Interactions

There is 1 disease interaction with Bactroban (mupirocin topical):


Mupirocin Topical (Includes Bactroban) ↔ Polyethylene Glycol

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction, Burns - External

Bactroban (brand of mupirocin) 2% ointment--but not the cream or the nasal ointment--is formulated in a polyethylene glycol base. Polyethylene glycol can be absorbed from open wounds and damaged skin, which is then excreted by the kidney where it may also produce serious toxicity. Bactroban 2% ointment should not be used in conditions where absorption of large quantities of polyethylene glycol might be expected (e.g., in severe burns), particularly if there is evidence of moderate or severe renal impairment.


  1. "Product Information. Bactroban (mupirocin)." SmithKline Beecham, Philadelphia, PA.

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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