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Misoprostol Disease Interactions

There are 2 disease interactions with misoprostol:


Misoprostol (applies to misoprostol) cardiovascular disease

Moderate Potential Hazard, Moderate plausibility.

Caution should be employed when administering misoprostol to patients with preexisting cardiovascular disease.


Misoprostol (applies to misoprostol) diarrhea

Moderate Potential Hazard, High plausibility. Applicable conditions: Inflammatory Bowel Disease, Dehydration

Diarrhea may occur in up to 40% of patients receiving misoprostol. Misoprostol should be administered cautiously in patients with underlying conditions such as inflammatory bowel disease and dehydration. Careful monitoring during therapy is recommended.


  1. "Product Information. Cytotec (misoprostol)." Searle, Skokie, IL.
  2. Wildeman RA "Focus on misoprostol: review of worldwide safety data." Clin Invest Med 10 (1987): 243-5

Misoprostol drug interactions

There are 13 drug interactions with misoprostol

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.