Hiprex Disease Interactions
There are 3 disease interactions with Hiprex (methenamine).
Methenamine (applies to Hiprex) crystalluria
Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Dehydration
The use of methenamine salts (i.e. methenamine hippurate or mandelate), but not the base, is contraindicated in patients with severe renal impairment or dehydration. Methenamine is excreted by the kidney and concentrated in the urine. In patients with low urinary output, the salts can precipitate and cause crystalluria.
Methenamine (applies to Hiprex) gout
Major Potential Hazard, Moderate plausibility.
Methenamine mandelate (salts), should be avoided in patients with gout as it may precipitate urate crystals in their urine. A similar situation may arise in patients with a predisposition to the formation of uric acid stones.
Methenamine (applies to Hiprex) liver disease
Major Potential Hazard, High plausibility.
The use of methenamine and its salts (i.e. methenamine hippurate or mandelate) is contraindicated in patients with severe hepatic impairment. Methenamine is hydrolyzed to ammonia and formaldehyde in the urine under acidic conditions. Patients with liver disease may already have elevated ammonia levels, which can cause or exacerbate hepatic encephalopathy. Methenamine hippurate has also been associated with isolated cases of transient elevations in serum transaminases. The manufacturer recommends periodic liver function tests during therapy, particularly in patients with preexisting liver dysfunction.
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Hiprex drug interactions
There are 64 drug interactions with Hiprex (methenamine).
More about Hiprex (methenamine)
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- During pregnancy
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- Drug class: urinary anti-infectives
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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