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Methenamine Mandelate use while Breastfeeding

Medically reviewed by Last updated on May 28, 2023.

Drugs containing Methenamine Mandelate: Hiprex, Uribel, Urogesic Blue, Uro-MP, Urised, Cystex Urinary Pain Relief, Cystex, Urelle, Phosphasal, Ustell, Show all 57 »Uta, Hyophen, Methylphen, Urimax, MHP-A, Uretron DS, Vilamit MB, Uro-L, UroAv-81, Urimar-T, Mandelamine, Prosed DS, Urophen MB, Urisedamine, Dolsed, Cystemms-V, Urapine, MSP-Blu, Usept, Uritact DS, UriSym, Uritact-EC, Utrona-C, Darpaz, UTICAP, Phosenamine, Darcalma, Uralgic, Urin D/S, Utira-C, Azuphen MB, UroAv-B, Hyolev MB, Uramit MB, UR N-C, UrNeva, Vilevev MB, Uro-SP, Uro-458, Uro Blue, Indiomin MB, Urolet MB, Urex, Uroqid-Acid No2, Utac, Visqid AA, Uro-Phosphate

Methenamine Mandelate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Both methenamine and mandelic acid pass into milk in small quantities. Methenamine mandelate appears acceptable to use, even while nursing a newborn.

Drug Levels

Maternal Levels. Six mothers nursing newborn infants were given methenamine hippurate 1 gram orally. Five hours after the dose, a mean methenamine concentration of 7 mg/L was found in milk. In two other women, milk concentrations averaged 9.1 mg/L at 2 to 3 hours after a 1 gram dose of methenamine hippurate orally and 4.3 mg/L at 6 to 7 hours after the dose. Based on the amount of milk ingested, the authors calculated the dose the infants received to be 0.05 to 0.1 mg/kg, which is about 1% of the adult dose.[1]

Six mothers were given mandelic acid 3 grams orally 4 times daily, a dose far in excess of that contained in a typical dose of methenamine mandelate. The authors estimated that their exclusively breastfed infants received an average 273 mg of mandelic acid daily in breastmilk. This amounted to an average daily dosage of 86 mg/kg in the 6 infants, which is about 48% of the adult dosage.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Four newborn infants were allowed to breastfeed in one study after a maternal dose of 1 gram of methenamine hippurate. No adverse effects were reported.[1]

Six infants were allowed to nurse during maternal ingestion of the large daily dosage of 12 grams of mandelic acid. There was no clinical or laboratory evidence of harm to the infants.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Methenamine Hippurate


Allgén LG, Holmberg G, Persson B, et al. Biological fate of methenamine in man. Acta Obstet Gynecol Scand. 1979;58:287–93. [PubMed: 484222]
Berger H. Excretion of mandelic acid in breast milk. Am J Dis Child. 1941;61:256–61.

Substance Identification

Substance Name

Methenamine Mandelate

CAS Registry Number


Drug Class

Breast Feeding


Anti-Infective Agents, Urinary

Antibacterial Agents

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Further information

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