Methenamine Hippurate use while Breastfeeding

Drugs containing Methenamine Hippurate: Uribel, Hiprex, Urex, Urogesic Blue, Cystex, Mandelamine, Urimax, Urelle, Hyophen, Methylphen, Show all 58 »Phosphasal, Uretron, Uro-MP, Uretron DS, Uramit MB, Ustell, Urin D/S, Urised, Uro-458, Urimar-T, Uroqid-Acid No2, Prosed EC, Indiomin MB, Uro-L, Uritin, Utira-C, Uro Blue, Urolet MB, Utac, Visqid AA, Uro-Phosphate, Uta, UR N-C, UroAv-B, UroAv-81, Hyolev MB, Azuphen MB, Phosenamine, Dolsed, Cystemms-V, Urapine, MSP-Blu, Atrosept, Trac Tabs 2x, Prosed DS, Urophen MB, Urisedamine, MHP-A, Usept, Uritact-EC, Darcalma, Darpaz, UTICAP, Utrona, Uritact DS, Utira, UriSym, Utrona-C

Methenamine Hippurate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Methenamine passes into milk in small quantities and appears safe to use, even while nursing a newborn.

Drug Levels

Maternal Levels. Six mothers nursing newborn infants were given methenamine hippurate 1 g orally. Five hours after the dose, a mean methenamine concentration of 7 mg/L was found in milk. In two other women, milk concentrations averaged 9.1 mg/L 2 to 3 hours after a 1 g dose of methenamine hippurate orally and 4.3 mg/L 6 to 7 hours after the dose. Based on the amount of milk ingested, the authors calculated the dose the infants received to be 0.05 to 0.1 mg/kg which is about 1% of the adult dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Four newborn infants were allowed to breastfeed in one study after a maternal dose of 1 g of methenamine hippurate. No adverse effects were reported.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Methenamine Mandelate

References

1. Allgen LG, Holmberg G, Persson B, Sorbo B. Biological fate of methenamine in man. Acta Obstet Gynecol Scand. 1979;58:287-93. PMID: 484222

Methenamine Hippurate Identification

Substance Name

Methenamine Hippurate

CAS Registry Number

5714-73-8

Drug Class

Anti-Infective Agents, Urinary

Administrative Information

LactMed Record Number

829

Last Revision Date

20130907

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