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Methenamine Hippurate use while Breastfeeding

Medically reviewed by Last updated on Aug 9, 2023.

Drugs containing Methenamine Hippurate: Hiprex, Uribel, Urogesic Blue, Mandelamine, Uro-MP, Cystex Urinary Pain Relief, Uretron DS, Urised, Cystex, Urimax, Show all 58 »Urelle, UroAv-81, Hyophen, Methylphen, Urapine, Uramit MB, Phosphasal, UTICAP, Phosenamine, Urin D/S, Urimar-T, Ustell, Urex, Uribel Tabs, Prosed DS, Urophen MB, Urisedamine, Dolsed, Cystemms-V, MSP-Blu, MHP-A, Usept, Uritact DS, UriSym, Uritact-EC, Utrona-C, Darpaz, Darcalma, Vilamit MB, Uro-L, Uralgic, Utira-C, Azuphen MB, UroAv-B, Hyolev MB, UR N-C, UrNeva, Vilevev MB, Uro-SP, Uro-458, Uro Blue, Uta, Indiomin MB, Urolet MB, Uroqid-Acid No2, Utac, Visqid AA, Uro-Phosphate

Methenamine Hippurate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Methenamine passes into milk in small quantities and appears safe to use, even while nursing a newborn.

Drug Levels

Maternal Levels. Six mothers nursing newborn infants were given methenamine hippurate 1 gram orally. Five hours after the dose, a mean methenamine concentration of 7 mg/L was found in milk. In two other women, milk concentrations averaged 9.1 mg/L at 2 to 3 hours after a 1 gram dose of methenamine hippurate orally and 4.3 mg/L at 6 to 7 hours after the dose. Based on the amount of milk ingested, the authors calculated the dose the infants received to be 0.05 to 0.1 mg/kg, which is about 1% of the adult dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Four newborn infants were allowed to breastfeed in one study after a maternal dose of 1 gram of methenamine hippurate. No adverse effects were reported.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Methenamine Mandelate


Allgén LG, Holmberg G, Persson B, et al. Biological fate of methenamine in man. Acta Obstet Gynecol Scand. 1979;58:287–93. [PubMed: 484222]

Substance Identification

Substance Name

Methenamine Hippurate

CAS Registry Number


Drug Class

Breast Feeding


Anti-Infective Agents, Urinary

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Further information

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