Methenamine Hippurate use while Breastfeeding
Drugs containing Methenamine Hippurate: Uribel, Hiprex, Cystex, Hyophen, Urelle, Mandelamine, Urogesic Blue, Uta, Phosphasal, Urised, Show all 57 »Prosed DS, Urex, Urimax, Utira-C, Methylphen, Uretron DS, Urin D/S, Uro-458, Atrosept, Ustell, MHP-A, Uramit MB, Uretron, Uro-Phosphate, Uro-MP, Azuphen MB, Uro-L, Indiomin MB, Uroqid-Acid No2, Utac, Visqid AA, Urolet MB, Uro Blue, UroAv-81, Hyolev MB, UroAv-B, Urimar-T, Urapine, MSP-Blu, Usept, Uritact DS, Cystemms-V, Dolsed, Urisedamine, Trac Tabs 2x, Uritin, Utira, Prosed EC, Darcalma, Darpaz, Phosenamine, UR N-C, Uritact-EC, UriSym, Utrona, UTICAP, Utrona-C
Methenamine Hippurate Levels and Effects while Breastfeeding
Summary of Use during Lactation
Methenamine passes into milk in small quantities and appears safe to use, even while nursing a newborn.
Maternal Levels. Six mothers nursing newborn infants were given methenamine hippurate 1 g orally. Five hours after the dose, a mean methenamine concentration of 7 mg/L was found in milk. In two other women, milk concentrations averaged 9.1 mg/L 2 to 3 hours after a 1 g dose of methenamine hippurate orally and 4.3 mg/L 6 to 7 hours after the dose. Based on the amount of milk ingested, the authors calculated the dose the infants received to be 0.05 to 0.1 mg/kg which is about 1% of the adult dose.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Four newborn infants were allowed to breastfeed in one study after a maternal dose of 1 g of methenamine hippurate. No adverse effects were reported.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
1. Allgen LG, Holmberg G, Persson B, Sorbo B. Biological fate of methenamine in man. Acta Obstet Gynecol Scand. 1979;58:287-93. PMID: 484222
Methenamine Hippurate Identification
CAS Registry Number
Anti-Infective Agents, Urinary
LactMed Record Number
Last Revision Date
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