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Equanil (meprobamate) Disease Interactions

There are 10 disease interactions with Equanil (meprobamate):

Major

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Alcohol Intox

Severe Potential Hazard, High plausibility

Applies to: Acute Alcohol Intoxication, Alcoholism

Anxiolytic, sedative, and hypnotic agents should generally not be given to patients with acute alcohol intoxication exhibiting depressed vital signs. The central nervous system depressant effects of these agents may be additive with those of alcohol. Severe respiratory depression and death may occur. Therapy with such agents should be administered cautiously in patients who might be prone to acute alcohol intake.

References

  1. "Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.
  3. "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.
View all 5 references
Major

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Depression

Severe Potential Hazard, Moderate plausibility

Applies to: Depression

A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. Some of these changes include decreased inhibition, aggressiveness, agitation, and hallucinations. These drugs can cause or exacerbate mental depression and cause suicidal behavior and ideation. Therapy with these drugs should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.

References

  1. "Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical, Abbott Park, IL.
  2. "Product Information. Ambien (zolpidem)." Searle, Skokie, IL.
  3. "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.
View all 5 references
Major

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Drug Dependence

Severe Potential Hazard, High plausibility

Applies to: Alcoholism, Drug Abuse/Dependence

Anxiolytic, sedative, and hypnotic agents have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use of excessive dosages, and abrupt cessation and/or a reduction in dosage may precipitate withdrawal symptoms. In patients who have developed tolerance, overdosage can still produce respiratory depression and death. Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously and for as brief a period as possible. Addiction-prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance or medical supervision when treated with these agents. In addition, it may be prudent to refrain from dispensing large quantities of medication to such patients. After prolonged use or if dependency is suspected, withdrawal of medication should be undertaken gradually using a dosage-tapering schedule.

References

  1. Gericke CA, Ludolph AC "Chronic abuse of zolpidem." JAMA 272 (1994): 1721-2
  2. Cavallaro R, Regazzetti MG, Covelli G, Smeraldi E "Tolerance and withdrawal with zolpidem." Lancet 342 (1993): 374-5
  3. "Product Information. Ambien (zolpidem)." Searle, Skokie, IL.
View all 7 references
Major

Meprobamate (Includes Equanil) ↔ Porphyria

Severe Potential Hazard, High plausibility

Applies to: Porphyria

The use of meprobamate is contraindicated in patients with acute intermittent porphyria. Meprobamate has been reported to precipitate acute attacks of porphyria in susceptible patients.

References

  1. "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.
Moderate

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Glaucoma

Moderate Potential Hazard, Moderate plausibility

Applies to: Glaucoma/Intraocular Hypertension, Urinary Retention

Some hypnotic drugs can have an anticholinergic effect and should be used with caution in patients with glaucoma, and trouble urinating due to retention or enlarged prostate.

Moderate

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

In general, anxiolytics, sedatives and hypnotics are extensively metabolized by the liver. Their plasma clearance may be decreased and their half-life prolonged in patients with impaired hepatic function. Therapy with these drugs should be administered cautiously in patients with liver disease (some are not recommended in severe liver impairment), and the dosage should be adjusted accordingly. Laboratory testing is recommended prior and during treatment.

Moderate

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Renal/Liver Disease

Moderate Potential Hazard, High plausibility

Applies to: Liver Disease, Renal Dysfunction

Some anxiolytics, sedatives and hypnotics are extensively metabolized by the liver, and excreted in the urine. Patients with impaired renal and/or hepatic function may be at greater risk for adverse effects, including central nervous system and respiratory depression, due to drug and metabolite accumulation. Therapy with these drugs should be administered cautiously in such patients, with careful dose selection usually starting at the low end of the dosing range.

References

  1. "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.
Moderate

Anxiolytics/Sedatives/Hypnotics (Includes Equanil) ↔ Resp Depression

Moderate Potential Hazard, Moderate plausibility

Applies to: Asphyxia, Pulmonary Impairment, Respiratory Arrest, Sleep Apnea

Oral anxiolytic, sedative, and hypnotic agents may cause respiratory depression and apnea when given in high dosages or following acute overdose. However, some patients may be susceptible at commonly used dosages, including the elderly, debilitated or severely ill patients, those receiving other CNS depressants, and those with limited ventilatory reserve, chronic pulmonary insufficiency or other respiratory disorders. Therapy with anxiolytic, sedative, and hypnotic agents should be administered cautiously in these patients. Appropriate monitoring and individualization of dosage are recommended.

References

  1. "Product Information. Ambien (zolpidem)." Searle, Skokie, IL.
  2. "Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical, Abbott Park, IL.
  3. "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.
View all 9 references
Moderate

Meprobamate (Includes Equanil) ↔ Drug Dependence

Moderate Potential Hazard, Moderate plausibility

Applies to: Drug Abuse/Dependence, Alcoholism

Physical dependence, psychological dependence, and abuse have occurred with the use of meprobamate. Chronic intoxication from prolonged use usually involves ingestion of greater than recommended doses, and it is manifested by ataxia, slurred speech, and vertigo. Careful supervision of dose and amounts prescribed is advised, as well as avoidance of prolonged administration, especially in alcoholics and other patients with known propensity for taking excessive quantities of drugs.

Moderate

Meprobamate (Includes Equanil) ↔ Seizure Disorders

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Meprobamate may occasionally precipitate seizures in epileptic patients. Therapy with meprobamate should be administered cautiously in patients with a history of epilepsy.

References

  1. "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.

Equanil (meprobamate) drug Interactions

There are 658 drug interactions with Equanil (meprobamate)

Equanil (meprobamate) alcohol/food Interactions

There is 1 alcohol/food interaction with Equanil (meprobamate)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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