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Magaldrate Disease Interactions

There are 3 disease interactions with magaldrate:

Major

Aluminum-containing antacids (applies to magaldrate) constipation

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Intestinal Obstruction, Phosphate Imbalance

Aluminum containing antacids may produce constipation, which may lead to intestinal obstruction. Osteomalacia and hypophosphatemia may be produced in patients with renal dysfunction who are not receiving dialysis. Patients with renal dysfunction, intestinal obstruction, osteomalacia, or hypophosphatemia should use antacids with low or no aluminum content.

References

  1. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
  2. "Product Information. Rolaids (dihydroxyaluminum sodium carbonate)." Warner Lambert Laboratories, Morris Plains, NJ.
  3. "Product Information. Amphojel (aluminum hydroxide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Major

Magnesium salts (applies to magaldrate) renal dysfunction

Major Potential Hazard, High plausibility.

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.

References

  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine, Erlanger, KY.
  2. "Product Information. Uro-Mag (magnesium oxide)." Blaine, Erlanger, KY.
  3. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
  4. "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.
  5. "Product Information. Magonate (magnesium gluconate)." Fleming and Company, Fenton, MO.
View all 5 references
Moderate

Magnesium-containing antacids (applies to magaldrate) diarrhea

Moderate Potential Hazard, Moderate plausibility.

The use of magnesium-containing antacids has been associated with a laxative effect and may cause diarrhea. Therapy with magnesium-containing antacids should be administered cautiously in patients with diarrhea.

References

  1. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.

Magaldrate drug interactions

There are 214 drug interactions with magaldrate

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.