Larotrectinib Disease Interactions
There is 1 disease interaction with larotrectinib.
Larotrectinib (applies to larotrectinib) hepatotoxicity/liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Forty- five percent of the patients receiving larotrectinib had increased hepatic parameters, including Grade 3 increased AST or ALT in 6% of patients. Monitor liver tests, including ALT and AST, every 2 weeks during the first month of treatment, then monthly thereafter, and as clinically indicated. Treatment should be withheld or permanently discontinued based on the severity of hepatic toxicity. Caution is advised in patients with moderate to severe hepatic impairment as the drug clearance was reduced in these patients (Child-Pugh B and C). Dose should be reduced on these patients as recommended by the manufacturers (refer to prescribing information).
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Larotrectinib drug interactions
There are 512 drug interactions with larotrectinib.
Larotrectinib alcohol/food interactions
There is 1 alcohol/food interaction with larotrectinib.
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- Drug class: multikinase inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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