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Guanethidine Disease Interactions

There is 1 disease interaction with guanethidine:


Antiadrenergic (peripheral) (applies to guanethidine) peripheral edema

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Fluid Retention

Peripheral- acting antiadrenergic agents can cause peripheral edema. Therapy with peripheral- acting antiadrenergic agents should be administered cautiously in patients adversely affected by sodium and water retention.


  1. "Product Information. Hytrin (terazosin)." Abbott Pharmaceutical, Abbott Park, IL.
  2. "Prazosin (Minipress) for hypertension." Med Lett Drugs Ther 19 (1977): 1-2
  3. "Product Information. Hydropres (reserpine-hydrochlorothiazide)." Merck & Co, Inc, West Point, PA.
  4. "Product Information. Ismelin (guanethidine)." Ciba Pharmaceuticals, Summit, NJ.
  5. Weil JV, Chidsey CA "Plasma volume expansion resulting from interference with adrenergic function in normal man." Circulation 37 (1968): 54-61
  6. "Product Information. Cardura (doxazosin)." Pfizer US Pharmaceuticals, New York, NY.
  7. "Product Information. Hylorel (guanadrel)." Rhone-Poulenc Rorer, Collegeville, PA.
View all 7 references

Guanethidine drug interactions

There are 263 drug interactions with guanethidine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.