Fostamatinib Disease Interactions

The use of fostamatinib may cause diarrhea. Monitor patients for the development of diarrhea during treatment with fostamatinib. It is recommended to manage diarrhea using supportive care measures, including dietary changes, hydration and/or antidiarrheal medication, early after the onset of symptoms. Interrupt, dose reduce, or discontinue treatment if diarrhea becomes severe (Grade 3 or above). Care should be exercised when using this agent in patients with diarrhea.

The use of fostamatinib may result in elevated liver function tests, mainly ALT and AST. It is recommended to monitor liver function tests monthly during treatment. Treatment with fostamatinib should be interrupted, reduced, or discontinued if ALT or AST increase more than 3 × ULN. Use care using this agent in patients with liver problems.

The use of fostamatinib may cause hypertension. It is recommended to monitor blood pressure every 2 weeks until stable, then monthly and to adjust or initiate antihypertensive therapy to ensure maintenance of blood pressure control during treatment. If increased blood pressure persists despite appropriate therapy, therapy interruption, reduction or discontinuation may be necessary. Caution should be exercised when using this agent in patients with pre-existing hypertension as they may be more susceptible to the hypertensive effects of fostamatinib.

Neutropenia has been reported in patients treated with fostamatinib. It is recommended to monitor the ANC monthly, and for infection during treatment and manage toxicity with treatment interruption, reduction or discontinuation.