Fezolinetant Disease Interactions
There are 2 disease interactions with fezolinetant.
Fezolinetant (applies to fezolinetant) hepatic impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Fezolinetant may increase serum transaminase levels. This drug is contraindicated in patients with known cirrhosis, and has not been studied in patients with Child-Pugh Class C hepatic impairment. Assess baseline liver function prior to starting therapy, then periodically as recommended or if symptoms of liver injury occur.
Fezolinetant (applies to fezolinetant) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Fezolinetant is contraindicated in patients with severe renal impairment or end-stage renal disease. Avoid use in patients with an estimated GFR less than 30 mL/min/m2.
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Fezolinetant drug interactions
There are 85 drug interactions with fezolinetant.
Fezolinetant alcohol/food interactions
There are 2 alcohol/food interactions with fezolinetant.
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- Drug class: miscellaneous central nervous system agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
