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Fezolinetant Disease Interactions

There are 2 disease interactions with fezolinetant.

Major

Fezolinetant (applies to fezolinetant) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Fezolinetant may increase serum transaminase levels. This drug is contraindicated in patients with known cirrhosis, and has not been studied in patients with Child-Pugh Class C hepatic impairment. Assess baseline liver function prior to starting therapy, then periodically as recommended or if symptoms of liver injury occur.

References

  1. (2023) "Product Information. Veozah (fezolinetant)." Astellas Pharma US, Inc
Major

Fezolinetant (applies to fezolinetant) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Fezolinetant is contraindicated in patients with severe renal impairment or end-stage renal disease. Avoid use in patients with an estimated GFR less than 30 mL/min/m2.

References

  1. (2023) "Product Information. Veozah (fezolinetant)." Astellas Pharma US, Inc

Fezolinetant drug interactions

There are 83 drug interactions with fezolinetant.

Fezolinetant alcohol/food interactions

There are 2 alcohol/food interactions with fezolinetant.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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