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Fezolinetant Disease Interactions

There are 2 disease interactions with fezolinetant.

Major

Fezolinetant (applies to fezolinetant) hepatotoxicity

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Fezolinetant is contraindicated in patients with known cirrhosis and has not been studied in patients with Child-Pugh C hepatic impairment. Drug exposure is increased in patients with Child-Pugh A or B hepatic impairment. Fezolinetant may increase serum transaminase levels and drug-induced liver injury has been reported within 40 days of initiation. Assess liver function at baseline, monthly for the first 3 months, then at 6 and 9 months of therapy, or if symptoms of liver injury occur. Do not initiate therapy if ALT, AST, or total bilirubin is 2 times the upper limit of normal or greater. Treatment discontinuation may be required if transaminase elevations occur.

Major

Fezolinetant (applies to fezolinetant) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Fezolinetant is contraindicated in patients with severe renal impairment or end-stage renal disease. Avoid use in patients with an estimated GFR less than 30 mL/min/1.73 m2.

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Fezolinetant drug interactions

There are 93 drug interactions with fezolinetant.

Fezolinetant alcohol/food interactions

There are 2 alcohol/food interactions with fezolinetant.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.