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Clevidipine Disease Interactions

There are 4 disease interactions with clevidipine.

Major

Clevidipine (applies to clevidipine) aortic stenosis

Major Potential Hazard, Moderate plausibility.

Clevidipine is contraindicated in patients with severe aortic stenosis because afterload reduction can be expected to reduce myocardial oxygen delivery.

References

  1. (2008) "Product Information. Cleviprex (clevidipine)." The Medicines Company
Major

Clevidipine (applies to clevidipine) lipid dysfunction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hyperlipidemia, Pancreatitis

Clevidipine is contraindicated in patients with defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis if it is accompanied by hyperlipidemia.

References

  1. (2008) "Product Information. Cleviprex (clevidipine)." The Medicines Company
Moderate

Clevidipine (applies to clevidipine) heart failure

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Congestive Heart Failure

The use of clevidipine can produce negative inotropic effects and exacerbate heart failure. It is recommended to monitor heart failure patients carefully during treatment with this agent.

References

  1. (2008) "Product Information. Cleviprex (clevidipine)." The Medicines Company
Moderate

Clevidipine (applies to clevidipine) hypotension

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Tachyarrhythmia

The use of clevidipine may produce systemic hypotension and reflex tachycardia. Dosage reduction may be necessary. There is limited experience with short-duration therapy with beta-blockers as a treatment for clevidipine -induced tachycardia; therefore, beta-blocker use for this purpose is not recommended. Close monitoring is recommended.

References

  1. (2008) "Product Information. Cleviprex (clevidipine)." The Medicines Company

Clevidipine drug interactions

There are 252 drug interactions with clevidipine.

Clevidipine alcohol/food interactions

There are 3 alcohol/food interactions with clevidipine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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