Tagamet HB Disease Interactions
There are 4 disease interactions with Tagamet HB (cimetidine).
Cimetidine (applies to Tagamet HB) liver disease
Major Potential Hazard, Moderate plausibility.
Cimetidine is partially metabolized by the liver, and to a greater extent when administered orally than when given intravenously. Although dosage reductions are generally not necessary, therapy with cimetidine should be administered cautiously in patients with liver disease. Hepatotoxicity has been associated with cimetidine use. In addition, liver disease appears to be a risk factor for cimetidine-related central nervous system toxicity, which may include mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation. These effects are usually reversible within 3 to 4 days after discontinuation of therapy.
H2 antagonists (applies to Tagamet HB) GI bleeding
Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage
Histamine H2 receptor antagonists should not be used in the presence of vomit with blood, or bloody or black stools. These might be serious conditions and the diagnosis needs to be ruled out.
Cimetidine (applies to Tagamet HB) hemodialysis
Moderate Potential Hazard, High plausibility.
Cimetidine is partially removed by hemodialysis and should be administered after dialysis.
Cimetidine (applies to Tagamet HB) renal dysfunction
Moderate Potential Hazard, High plausibility.
Cimetidine and its metabolites are primarily eliminated by the kidney. The daily dosage should initially be reduced in patients with moderate to severe renal impairment (CrCl < 50 mL/min). If necessary, the daily dosage may be increased with caution. Renal dysfunction also appears to be a risk factor for cimetidine-related central nervous system toxicity, which may include mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation. These effects are generally reversible within 3 to 4 days after discontinuation of therapy.
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Tagamet HB drug interactions
There are 487 drug interactions with Tagamet HB (cimetidine).
Tagamet HB alcohol/food interactions
There are 3 alcohol/food interactions with Tagamet HB (cimetidine).
More about Tagamet HB (cimetidine)
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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