Zyrtec Hives (cetirizine) Disease Interactions
There are 2 disease interactions with Zyrtec Hives (cetirizine):
Cetirizine (Includes Zyrtec Hives) ↔ Alcohol
Moderate Potential Hazard, Moderate plausibility
Applies to: Acute Alcohol Intoxication
Alcohol should be avoided when using cetirizine, and some other antihistamines. Cetirizine may produce drowsiness that may be increase by the use of alcohol, sedatives and tranquilizers.
Cetirizine (Includes Zyrtec Hives) ↔ Renal/Liver Disease
Moderate Potential Hazard, High plausibility
Applies to: Renal Dysfunction, Liver Disease
Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.
- Simons FE, Watson WT, Minuk GY, Simons KJ "Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis." J Clin Pharmacol 33 (1993): 949-54
- Horsmans Y, Desager JP, Hulhoven R, Harvengt C "Single-dose pharmacokinetics of cetirizine in patients with chronic liver disease." J Clin Pharmacol 33 (1993): 929-32
- "Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
Zyrtec Hives (cetirizine) drug Interactions
There are 571 drug interactions with Zyrtec Hives (cetirizine)
Zyrtec Hives (cetirizine) alcohol/food Interactions
There is 1 alcohol/food interaction with Zyrtec Hives (cetirizine)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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