PediaCare Children's 24-Hour Allergy (cetirizine) Disease Interactions
There are 2 disease interactions with PediaCare Children's 24-Hour Allergy (cetirizine):
Cetirizine (applies to PediaCare Children's 24-Hour Allergy) alcohol
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Acute Alcohol Intoxication
Alcohol should be avoided when using cetirizine, and some other antihistamines. Cetirizine may produce drowsiness that may be increase by the use of alcohol, sedatives and tranquilizers.
Cetirizine (applies to PediaCare Children's 24-Hour Allergy) renal/liver disease
Moderate Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction
Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.
- Simons FE, Watson WT, Minuk GY, Simons KJ "Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis." J Clin Pharmacol 33 (1993): 949-54
- "Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
- Campoli-Richards DM, Buckley MM, Fitton A "Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria." Drugs 40 (1990): 762-81
- Matzke GR, Yeh J, Awni WM, Halstenson CE, Chung M "Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency." Ann Allergy 59 (1987): 25-30
- Barnes CL, McKenzie CA, Webster KD, Poinsett-Holmes K "Cetirizine: a new, nonsedating antihistamine." Ann Pharmacother 27 (1993): 464-70
- Horsmans Y, Desager JP, Hulhoven R, Harvengt C "Single-dose pharmacokinetics of cetirizine in patients with chronic liver disease." J Clin Pharmacol 33 (1993): 929-32
- Awni WM, Yeh J, Halstenson CE, Opsahl JA, Chung M, Matzke GR "Effect of haemodialysis on the pharmacokinetics of cetirizine." Eur J Clin Pharmacol 38 (1990): 67-9
- Rihoux JP, Mariz S "Cetirizine. An updated review of its pharmacological properties and therapeutic efficacy." Clin Rev Allergy 11 (1993): 65-88
PediaCare Children's 24-Hour Allergy (cetirizine) drug interactions
There are 243 drug interactions with PediaCare Children's 24-Hour Allergy (cetirizine)
PediaCare Children's 24-Hour Allergy (cetirizine) alcohol/food interactions
There is 1 alcohol/food interaction with PediaCare Children's 24-Hour Allergy (cetirizine)
More about PediaCare Children's 24-Hour Allergy (cetirizine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Drug class: antihistamines
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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