Aprepitant Disease Interactions
There is 1 disease interaction with aprepitant.
Aprepitant (applies to aprepitant) liver disease
Moderate Potential Hazard, Moderate plausibility.
Aprepitant is primarily metabolized by the liver. In studies of patients with mild to moderate hepatic impairment (Child-Pugh score 5 to 9), aprepitant was well tolerated and no clinically significant alterations in its pharmacokinetics were observed. Thus, no dosage adjustment of aprepitant is necessary in this patient population. However, there are no clinical or pharmacokinetic data in patients with severe hepatic impairment (Child-Pugh score > 9), and caution is advised if aprepitant is used in such patients.
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Aprepitant drug interactions
There are 455 drug interactions with aprepitant.
Aprepitant alcohol/food interactions
There is 1 alcohol/food interaction with aprepitant.
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- During pregnancy
- Drug class: NK1 receptor antagonists
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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