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Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone) Disease Interactions

There are 4 disease interactions with Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone):

Major

Aluminum-containing antacids (applies to Di-Gel) constipation

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Intestinal Obstruction, Phosphate Imbalance

Aluminum containing antacids may produce constipation, which may lead to intestinal obstruction. Osteomalacia and hypophosphatemia may be produced in patients with renal dysfunction who are not receiving dialysis. Patients with renal dysfunction, intestinal obstruction, osteomalacia, or hypophosphatemia should use antacids with low or no aluminum content.

References

  1. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
  2. "Product Information. Rolaids (dihydroxyaluminum sodium carbonate)." Warner Lambert Laboratories, Morris Plains, NJ.
  3. "Product Information. Amphojel (aluminum hydroxide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Major

Laxatives (applies to Di-Gel) inflammatory bowel disease

Major Potential Hazard, Moderate plausibility.

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

References

  1. "Product Information. Fleet Bisacodyl Enema (bisacodyl)." Fleet, Lynchburg, VA.
  2. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc, Woodbridge, NJ.
Major

Laxatives (applies to Di-Gel) intestinal obstruction disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

References

  1. "Product Information. Kondremul (mineral oil)." Bristol-Myers Squibb, Princeton, NJ.
  2. "Product Information. Fleet Bisacodyl Enema (bisacodyl)." Fleet, Lynchburg, VA.
  3. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc, Woodbridge, NJ.
  4. "Product Information. Fleet Mineral Oil Enema (mineral oil)." Fleet, Lynchburg, VA.
  5. "Product Information. Fleet Babylax (glycerin)." Alcon Laboratorries Inc, Fort Worth, TX.
View all 5 references
Major

Magnesium salts (applies to Di-Gel) renal dysfunction

Major Potential Hazard, High plausibility.

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.

References

  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine, Erlanger, KY.
  2. "Product Information. Uro-Mag (magnesium oxide)." Blaine, Erlanger, KY.
  3. "Product Information. Losospan (magaldrate)." Whitehall-Robbins, Madison, NJ.
  4. "Product Information. Slow-Mag (magnesium chloride)." Searle, Skokie, IL.
  5. "Product Information. Magonate (magnesium gluconate)." Fleming and Company, Fenton, MO.
View all 5 references

Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone) drug interactions

There are 399 drug interactions with Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone)

Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone) alcohol/food interactions

There is 1 alcohol/food interaction with Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone)

More about Di-Gel (aluminum hydroxide / magnesium hydroxide / simethicone)

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.