Hyaluronate sodium (Injection)
Generic Name: sodium hyaluronate (hye-al-ure-ON-ate SOE-dee-um)
Medically reviewed by Drugs.com. Last updated on April 11, 2021.
Commonly used brand name(s)
In the U.S.
- Hyalgan L/L
- Supartz FX
Available Dosage Forms:
Therapeutic Class: Antirheumatic
Uses for hyaluronate sodium
Hyaluronate is similar to a substance that occurs naturally in joints and that helps joints work properly by acting like a lubricant and shock absorber. Hyaluronate sodium is injected directly into the knee to relieve pain caused by osteoarthritis.
Hyaluronate sodium is to be administered only by or under the immediate supervision of your doctor.
Before using hyaluronate sodium
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For hyaluronate sodium, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to hyaluronate sodium or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on hyaluronate sodium have been done only in adult patients, and there is no specific information comparing use of hyaluronate in children with use in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of hyaluronate in the elderly with the use in other age groups.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of hyaluronate sodium. Make sure you tell your doctor if you have any other medical problems, especially:
- Skin infection or other problems at the place where the injection is to be given—Hyaluronate sodium should not be injected there.
Proper use of hyaluronate sodium
The dose of hyaluronate sodium will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of hyaluronate sodium. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For parenteral dosage form (injection):
- For knee pain caused by osteoarthritis:
- Adults—By injection into the knee, 20 milligrams (mg) once a week (one week apart) for a total of five injections.
- Children—Use and dose must be determined by your doctor.
- For knee pain caused by osteoarthritis:
Precautions while using hyaluronate sodium
For the first 48 hours after you receive hyaluronate sodium, avoid strenuous activities or prolonged (more than 1 hour) activities that put a lot of weight on your legs, such as jogging, heavy lifting, playing tennis, or standing on your feet for a long period of time.
Hyaluronate sodium side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- Blue color or flushing or redness of skin
- difficulty in swallowing
- dizziness or feeling faint (severe)
- redness or pain at place of injection
- skin rash, hives, and/or itching
- stuffy nose
- swelling of eyelids, face, or lips
- tightness in chest, troubled breathing, and/or wheezing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- itching of the skin
- large, nonelevated blue or purplish patches in the skin
- loss of appetite
- nausea and/or vomiting
- stomach pain
- swelling of the knee
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about sodium hyaluronate
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- 435 Reviews
- Drug class: viscosupplementation agents
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.