aspirin and omeprazole (Oral route)
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
- Tablet, Delayed Release
Therapeutic Class: Platelet Aggregation Inhibitor
Pharmacologic Class: NSAID
Chemical Class: Salicylate, Aspirin
Uses For aspirin and omeprazole
Aspirin and omeprazole combination is used in patients who need aspirin to prevent heart and blood vessel problems (eg, heart attack, stroke) and who are at risk of developing stomach ulcers caused by aspirin.
Aspirin is a salicylate medicine and used to lower risk of heart attack in patients with chronic coronary artery disease, such as patients with history of heart attack or angina (severe chest pain). It is also used to lower risk of recurrent stroke in patients who had an ischemic stroke or transient ischemic attack. Omeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.
aspirin and omeprazole is available only with your doctor's prescription.
Before Using aspirin and omeprazole
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aspirin and omeprazole, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to aspirin and omeprazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of aspirin and omeprazole combination in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aspirin and omeprazole combination in the elderly.
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using aspirin and omeprazole.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aspirin and omeprazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using aspirin and omeprazole with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Influenza Virus Vaccine, Live
Using aspirin and omeprazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alipogene Tiparvovec
- Alteplase, Recombinant
- Amtolmetin Guacil
- Beta Glucan
- Choline Salicylate
- Dabigatran Etexilate
- Eslicarbazepine Acetate
- Ethacrynic Acid
- Flufenamic Acid
- Mefenamic Acid
- Mycophenolate Mofetil
- Mycophenolic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Pentosan Polysulfate Sodium
- Protein C
- Reteplase, Recombinant
- Salicylic Acid
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
- Varicella Virus Vaccine
Using aspirin and omeprazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Enalapril Maleate
- Ginkgo Biloba
- St John's Wort
- Valproic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using aspirin and omeprazole with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aspirin and omeprazole, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of aspirin and omeprazole. Make sure you tell your doctor if you have any other medical problems, especially:
- Alcohol abuse or history of or
- Bleeding problems (eg, hemophilia) or
- Cutaneous lupus erythematosus or
- Diarrhea or
- Hypomagnesemia (low magnesium in the blood), history of or
- Kidney disease or
- Liver disease or
- Osteoporosis (bone problem) or
- Stomach ulcers or bleeding, history of or
- Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.
- Aspirin-sensitive asthma or
- Aspirin sensitivity, history of or
- Viral infections in children, suspected—Should not be used in patients with these conditions.
Proper Use of aspirin and omeprazole
Take aspirin and omeprazole only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
aspirin and omeprazole should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
Take aspirin and omeprazole at least 60 minutes before a meal.
Swallow the delayed-release tablet whole with liquid. Do not split, chew, crush, or dissolve it.
The dose of aspirin and omeprazole will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of aspirin and omeprazole. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (delayed release tablets):
- To prevent heart and blood vessel problems and who are at risk of developing stomach ulcers caused by aspirin:
- Adults—1 tablet once a day. Each tablet contains 81 or 325 milligrams (mg) of aspirin and 40 mg of omeprazole.
- Children—Use and dose must be determined by your doctor.
- To prevent heart and blood vessel problems and who are at risk of developing stomach ulcers caused by aspirin:
If you miss a dose of aspirin and omeprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using aspirin and omeprazole
It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Do not use aspirin and omeprazole if you are also using medicines containing rilpivirine (Edurant®, Complera®, Odefsey®). Using these medicines together may cause unwanted side effects.
Tell your doctor if you are of Asian descent, such as Filipino, Chinese, Japanese, Korean, or Taiwanese. You may need a lower dose of aspirin and omeprazole.
Serious stomach conditions may occur while taking aspirin and omeprazole. Check with your doctor immediately if you are having more than one of these symptoms: abdominal or stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody sometimes, fever, nausea or vomiting, or unusual tiredness or weakness.
Check with your doctor right away if you have a bloody urine, decrease amount of urine, a fever, joint pain, lower back or side pain, skin rash, trouble breathing, swelling of the body, feet, or ankles, or unusual weight gain after using aspirin and omeprazole. These may be symptoms of a serious kidney problem (including acute interstitial nephritis).
aspirin and omeprazole may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of aspirin and omeprazole, or use it for one year or more.
Cutaneous or systemic lupus erythematosus may occur or gets worse in lupus patients and are taking PPI. Call your doctor right away if you have a joint pain or skin rash on your cheeks or arms that gets worse when exposed in the sun.
Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Drinking alcohol while using aspirin and omeprazole may increase your risk of liver damage. If you drink 3 or more alcoholic drinks every day, tell your doctor.
Taking aspirin and omeprazole for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency.
aspirin and omeprazole may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking aspirin and omeprazole for more than one year, or if you are taking aspirin and omeprazole together with digoxin (Lanoxin®) or certain diuretics or "water pills". Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.
Do not stop using aspirin and omeprazole suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
Using aspirin and omeprazole during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using aspirin and omeprazole, tell your doctor right away.
aspirin and omeprazole may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using aspirin and omeprazole.
Make sure any doctor or dentist who treats you knows that you are using aspirin and omeprazole. You may need to stop using aspirin and omeprazole several days before you have medical tests.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
aspirin and omeprazole Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:Incidence not known
- Abdominal or stomach pain, cramping, or burning
- abdominal or stomach tenderness
- black, tarry stools blisters, hives, or itching
- bloody urine
- chest pain
- decreased frequency or amount of urine
- fever and chills
- general feeling of discomfort or illness
- hair loss
- increased thirst
- loss of appetite
- lower back or side pain
- mood or mental changes
- muscle or joint pain
- muscle spasms (tetany) or twitching
- nausea or vomiting
- pain or swelling in the arms or legs without any injury
- severe abdominal or stomach cramps and pain
- skin rash
- sore throat
- swelling of the face, fingers, or lower legs
- swollen glands
- troubled breathing
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- watery and severe diarrhea, which may also be bloody
- weight gain
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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More about aspirin/omeprazole
- Side Effects
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- Drug class: platelet aggregation inhibitors
Other brands: Yosprala