Comparing Sumatriptan vs Tizanidine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Sumatriptan	Tizanidine	Enter another drug to compare

Sumatriptan

Tizanidine

Prescription only

Sumatriptan may be used to quickly relieve the symptoms of a migraine but may not be suitable for everyone including those with pre-existing cardiovascular conditions. Prescribed for Cluster... View more

Prescription only

Tizanidine may be used to reduce muscle spasms but common side effects include sleepiness, a drop in blood pressure, and a dry mouth. The dosage of tizanidine should be tailored to each person and... View more

More about Sumatriptan

More about Tizanidine

Ratings & Reviews

Sumatriptan has an average rating of 7.7 out of 10 from a total of 549 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 17% reported a negative effect.

Tizanidine has an average rating of 6.2 out of 10 from a total of 381 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect.

View all 549 reviews

View all 381 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (13.5%)
Drowsiness (6.6%)
Pain (6.4%)
Chest pain (5.1%)
Dizziness (5.1%)
Vomiting (4.4%)
Tiredness (4.2%)

View all Sumatriptan side effects

Drowsiness (18.9%)
Dry mouth (9.2%)
Hallucinations (6.8%)
Dizziness (6.3%)
Tiredness (5.5%)
Vivid dreams (4.2%)
Headaches (3.7%)

View all Tizanidine side effects

Drug Class

Antimigraine agents

Skeletal muscle relaxants

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	0.5 mL
Strength	6 mg/0.5 mL
Per unit^*	$41.00 - $105.76
Cost^*	$20.50 - $52.88

View all Sumatriptan prices

Quantity	50 each
Strength	4 mg
Per unit^*	$0.61
Cost^*	$30.51

View all Tizanidine prices

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Dosage Forms

Nasal spray
Oral tablet
Subcutaneous solution

Oral capsule
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

6 hours

2.5 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 100 drugs are known to interact with Sumatriptan:

70 major drug interactions (280 brand and generic names)
30 moderate drug interactions (166 brand and generic names)

A total of 647 drugs are known to interact with Tizanidine:

246 major drug interactions (972 brand and generic names)
399 moderate drug interactions (1597 brand and generic names)
2 minor drug interactions (4 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Using tiZANidine together with alcohol may increase side effects such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

January 28, 2016

November 27, 1996

WADA Class View classifications

N/A

More Information

Patient Resources

Tizanidine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Sumatriptan vs Tizanidine

See also:

Ubrelvy

Nurtec ODT

Qulipta

Celebrex

Botox

Topamax

Advil

Reglan

Voltaren

Imitrex

Further information

Comparing Sumatriptan vs Tizanidine

See also:

Further information

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