Comparing Janumet vs Synjardy XR

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Janumet (metformin / sitagliptin)	Synjardy XR (empagliflozin / metformin)	Enter another drug to compare

Janumet (metformin / sitagliptin)

Synjardy XR (empagliflozin / metformin)

Prescription only

Prescribed for Type 2 Diabetes. Janumet may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Type 2 Diabetes. Synjardy XR may also be used for purposes not listed in this medication guide.

More about Janumet (metformin / sitagliptin)

More about Synjardy XR (empagliflozin / metformin)

Ratings & Reviews

Janumet has an average rating of 6.3 out of 10 from a total of 66 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 29% reported a negative effect.

Synjardy XR has an average rating of 4.9 out of 10 from a total of 11 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 55% reported a negative effect.

View all 66 reviews

View all 11 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (15.2%)
Nausea (13.6%)
Diarrhea (10.6%)
Dizziness (10.6%)
Upset stomach (9.1%)
Vomiting (6.1%)
Rash (4.5%)

View all Janumet side effects

View all Synjardy XR side effects

Drug Class

Antidiabetic combinations

Antidiabetic combinations

Generic Availability

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	60 tablet
Strength	500 mg-50 mg
Per unit^*	$6.04
Cost^*	$362.28

View all Janumet prices

Quantity	60 tablet, extended release
Strength	12.5 mg-1000 mg
Per unit^*	$11.37
Cost^*	$681.93

View all Synjardy XR prices

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Dosage Forms

Oral tablet

Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

17.6 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 404 drugs are known to interact with Janumet:

25 major drug interactions (131 brand and generic names)
367 moderate drug interactions (1845 brand and generic names)
12 minor drug interactions (43 brand and generic names)

A total of 520 drugs are known to interact with Synjardy XR:

25 major drug interactions (136 brand and generic names)
485 moderate drug interactions (2203 brand and generic names)
10 minor drug interactions (37 brand and generic names)

Alcohol/Food/Lifestyle Interactions

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Disease Interactions

First Approval Date

March 30, 2007

December 09, 2016

WADA Class View classifications

N/A

More Information

Patient Resources

Janumet uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Janumet vs Synjardy XR

See also:

Ozempic

Rybelsus

Mounjaro

Trulicity

Lantus

Tresiba

Victoza

Levemir

Basaglar

Novolog

Further information

Comparing Janumet vs Synjardy XR

See also:

Further information

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