Skip to main content

Synjardy XR Dosage

Generic name: EMPAGLIFLOZIN 10mg, METFORMIN HYDROCHLORIDE 1000mg
Dosage form: tablet, extended release
Drug class: Antidiabetic combinations

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

Prior to Initiation of SYNJARDY XR

Recommended Dosage and Administration

  • Individualize the starting dose of SYNJARDY XR based on the patient's current regimen:
    • In patients on metformin HCl, switch to SYNJARDY XR containing a similar total daily dose of metformin HCl and a total daily dose of empagliflozin 10 mg;
    • In patients on empagliflozin, switch to SYNJARDY XR containing the same total daily dose of empagliflozin and a total daily dose of metformin HCl extended-release 1000 mg;
    • In patients already treated with empagliflozin and metformin HCl, switch to SYNJARDY XR containing the same total daily doses of empagliflozin and a similar total daily dose of metformin HCl.
  • Monitor effectiveness and tolerability, and adjust dosing as appropriate, not to exceed the maximum recommended daily dose of empagliflozin 25 mg and metformin HCl 2000 mg.
  • The dose of metformin HCl should be gradually escalated to reduce the gastrointestinal side effects due to metformin.
  • Take SYNJARDY XR orally once daily with a meal in the morning
  • Swallow SYNJARDY XR tablets whole. Do not split, crush, dissolve, or chew.
  • SYNJARDY XR 10 mg/1000 mg and 25 mg/1000 mg tablets should be taken as a single tablet once daily. SYNJARDY XR 5 mg/1000 mg and 12.5 mg/1000 mg tablets should be taken as two tablets together once daily.

Dosage Recommendations in Patients with Renal Impairment

Discontinuation for Iodinated Contrast Imaging Procedures

Discontinue SYNJARDY XR at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR less than 60 mL/min/1.73 m2; in patients with a history of liver disease, alcoholism or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure; restart SYNJARDY XR if renal function is stable [see Warnings and Precautions (5.1)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.