Comparing Guaiatussin AC vs Promethazine VC With Codeine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Guaiatussin AC (codeine / guaifenesin)	Promethazine VC with Codeine (codeine / phenylephrine / promethazine)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Guaiatussin AC (codeine / guaifenesin)	Promethazine VC with Codeine (codeine / phenylephrine / promethazine)	Enter another drug to compare
Prescription only Prescribed for Cough. Guaiatussin AC may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Cough and Nasal Congestion. Promethazine VC with Codeine may also be used for purposes not listed in this medication guide.
More about Guaiatussin AC (codeine / guaifenesin)	More about Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
Ratings & Reviews
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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
View all Guaiatussin AC side effects	View all Promethazine VC with Codeine side effects
Drug Class
Upper respiratory combinations	Upper respiratory combinations
Generic Availability
N/A	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
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Dosage Forms
Oral syrup	Oral syrup
Brand Names
Other codeine / guaifenesin brands include: Allfen CD, Allfen CDX, Bitex Liquid, Brontex, Cheracol with Codeine, Cheratussin AC, Codafen, Codar GF, Dex-Tuss, Diabetic Tussin C, Duraganidin NR, ExeClear-C, Gani-Tuss NR, Glydeine, Guai-Co, Guaifen AC, Guaifen-C, Guaifenesin AC, Guaitussin AC, Guiatuss AC, Guiatussin with Codeine, M-Clear WC, Mar-cof CG, Mytussin AC, Pro-Clear, Robafen AC, Virtussin A/C View more	N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
3.5 hours	16 hours
CSA Schedule ¹ View glossary of CSA terms
M Multiple The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.	5 Some potential for abuse Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	C Category C Risk cannot be ruled out See the full pregnancy warnings document.
Drug Interactions
A total of 529 drugs are known to interact with Guaiatussin AC: 124 major drug interactions (497 brand and generic names) 402 moderate drug interactions (1632 brand and generic names) 3 minor drug interactions (7 brand and generic names)	A total of 826 drugs are known to interact with Promethazine VC with Codeine: 217 major drug interactions (787 brand and generic names) 597 moderate drug interactions (2482 brand and generic names) 12 minor drug interactions (52 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more	Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
Disease Interactions
Impaired GI motility Infectious diarrhea Prematurity Acute alcohol intoxication Drug dependence Hypotension Intracranial pressure Respiratory depression Gastrointestinal obstruction Adrenal insufficiency Liver disease Renal dysfunction Seizure disorders Urinary retention Arrhythmias Biliary tract disease	Impaired GI motility Infectious diarrhea Prematurity Acute alcohol intoxication Drug dependence Hypotension Intracranial pressure Respiratory depression Gastrointestinal obstruction Acute alcohol intoxication CNS depression Hematologic toxicity Hypotension Liver disease Antidopaminergic effects 1 Asthma Cardiovascular disease Anticholinergic effects Asthma/COPD Adrenal insufficiency Liver disease Renal dysfunction Seizure disorders Urinary retention Arrhythmias Biliary tract disease Breast cancer NMS Seizure disorders Antidopaminergic effects 2 BPH Diabetes Glaucoma
First Approval Date
N/A	N/A
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings	Side effects Drug interactions Dosage Pregnancy warnings
Patient Resources
Guaiatussin AC uses	Promethazine VC with Codeine uses
Professional Resources
N/A	Prescribing information
Related Treatment Guide
Cough	Cough and Nasal Congestion

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

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Medical Disclaimer

Comparing Guaiatussin AC vs Promethazine VC With Codeine

See also:

Benadryl

Norco

Ozempic

Mucinex

Vicodin

Dilaudid

Hydromorphone

Codeine

Dextromethorphan

Guaifenesin

Further information

Comparing Guaiatussin AC vs Promethazine VC With Codeine

See also:

Further information

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