Comparing Estradiol Topical vs Premarin Vaginal
| Estradiol topical | Premarin Vaginal (conjugated estrogens) |
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| Estradiol topical | Premarin Vaginal (conjugated estrogens) |
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Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Overactive Bladder, Dyspareunia. Estradiol topical may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Postmenopausal Symptoms. Premarin Vaginal may also be used for purposes not listed in this medication guide. |
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| More about Estradiol topical | More about Premarin Vaginal (conjugated estrogens) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Estradiol topical has an average rating of 5.1 out of 10 from a total of 487 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 45% reported a negative effect. |
Premarin Vaginal has an average rating of 7.3 out of 10 from a total of 21 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Estradiol topical side effects |
View all Premarin Vaginal side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Estradiol topical prices |
View all Premarin Vaginal prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Estrace Vaginal Cream, Estring, Imvexxy, Vagifem, Yuvafem |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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N/A |
8 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 244 drugs are known to interact with Estradiol topical:
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A total of 174 drugs are known to interact with Premarin Vaginal:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
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| First Approval Date | |||||||||||||||||
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January 31, 1984 |
N/A |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.