Comparing Donepezil vs Memantine
| Donepezil | Memantine |
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| Donepezil | Memantine |
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Prescription only
Donepezil boosts the effects of acetylcholine, a neurotransmitter that is noticeably depleted in people with Alzheimer's disease. Side effects are more likely at higher dosages and include nausea... View more |
Prescription only
Prescribed for Alzheimer's Disease, Migraine, Autism. Memantine may also be used for purposes not listed in this medication guide. |
Related suggestions Popular comparisons
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| More about Donepezil | More about Memantine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Donepezil has an average rating of 5.8 out of 10 from a total of 141 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 32% reported a negative effect. |
Memantine has an average rating of 6.3 out of 10 from a total of 108 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Donepezil side effects |
View all Memantine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Donepezil prices |
View all Memantine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Adlarity, Aricept, Aricept ODT | Namenda, Namenda XR | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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70 hours |
80 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 526 drugs are known to interact with Donepezil:
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A total of 43 drugs are known to interact with Memantine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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November 25, 1996 |
October 16, 2003 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.