Comparing Donepezil vs Memantine
| Donepezil | Memantine |
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| Donepezil | Memantine |
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Prescription only
Donepezil boosts the effects of acetylcholine, a neurotransmitter that is noticeably depleted in people with Alzheimer's disease. Side effects are more likely at higher dosages and include nausea... View more |
Prescription only
Prescribed for Alzheimer's Disease, Migraine, Autism. Memantine may also be used for purposes not listed in this medication guide. |
Related suggestions Popular comparisons
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| More about Donepezil | More about Memantine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Donepezil has an average rating of 5.7 out of 10 from a total of 133 ratings on Drugs.com. 44% of reviewers reported a positive effect, while 34% reported a negative effect. |
Memantine has an average rating of 6.3 out of 10 from a total of 104 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 30% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Donepezil prices |
View all Memantine prices |
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| Dosage Forms Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Adlarity, Aricept, Aricept ODT | Namenda, Namenda XR | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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70 hours |
80 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 499 drugs are known to interact with Donepezil:
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A total of 43 drugs are known to interact with Memantine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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November 25, 1996 |
October 16, 2003 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.