Comparing Donepezil vs Memantine
| Donepezil | Memantine |
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| Donepezil | Memantine |
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Prescription only
Donepezil boosts the effects of acetylcholine, a neurotransmitter that is noticeably depleted in people with Alzheimer's disease. Side effects are more likely at higher dosages and include nausea... View more |
Prescription only
Prescribed for Alzheimer's Disease, Migraine, Autism. Memantine may also be used for purposes not listed in this medication guide. |
Related suggestions Popular comparisons
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| More about Donepezil | More about Memantine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Donepezil has an average rating of 5.9 out of 10 from a total of 146 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 31% reported a negative effect. |
Memantine has an average rating of 6.4 out of 10 from a total of 117 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 26% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Donepezil side effects |
View all Memantine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Donepezil prices |
View all Memantine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Adlarity, Aricept, Aricept ODT | Namenda, Namenda XR | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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70 hours |
80 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 528 drugs are known to interact with Donepezil:
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A total of 43 drugs are known to interact with Memantine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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November 25, 1996 |
October 16, 2003 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.