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Donepezil Dosage

Medically reviewed by Last updated on Oct 26, 2023.

Applies to the following strengths: 5 mg; 10 mg; 23 mg; 5 mg/24 hr; 10 mg/24 hr

Usual Adult Dose for Alzheimer's Disease

Initial dose: 5 mg orally once a day, in the evening prior to retiring

Mild to moderate Alzheimer's disease:

Moderate to severe Alzheimer's disease:

Comments: A higher dose of 10 mg may or may not provide a statistically significantly greater clinical benefit than a 5 mg dose. Prescriber and patient's preference should be considered.

Uses: For mild, moderate, and severe Alzheimer's type dementia

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

In clinical studies, the increase to a 10 mg dose with a one week titration was associated with a higher incidence of cholinergic adverse events compared to a 5 mg dose. The type and frequency of these adverse events were similar for both the 5 mg and 10 mg dose when using a 6 week titration.
Recommended titration rate:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.