Comparing Chlorpromazine vs Promethazine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Chlorpromazine	Promethazine	Enter another drug to compare

Chlorpromazine

Promethazine

Prescription only

Prescribed for Hiccups, Mania, Light Sedation, Nausea/Vomiting, Opiate Withdrawal, Porphyria, Psychosis, Schizophrenia, Tetanus. Chlorpromazine may also be used for purposes not listed in this... View more

Prescription only

Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect and it may interact with several other drugs including antidepressants, antipsychotics, and other... View more

More about Chlorpromazine

More about Promethazine

Ratings & Reviews

Chlorpromazine has an average rating of 7.0 out of 10 from a total of 70 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 26% reported a negative effect.

Promethazine has an average rating of 7.2 out of 10 from a total of 389 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 70 reviews

View all 389 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (8.6%)
Brain fog (5.7%)
Tiredness (5.7%)
Anxiety (4.3%)

View all Chlorpromazine side effects

Drowsiness (20.6%)
Nausea (14.4%)
Vomiting (6.7%)
Anxiety (5.7%)
Tiredness (5.7%)
Sleepy (5.4%)
Dizziness (4.9%)

View all Promethazine side effects

Drug Class

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	25 mg
Per unit^*	$2.10 - $2.20
Cost^*	$105.13 - $109.90

View all Chlorpromazine prices

Quantity	1 tablet
Strength	25 mg
Per unit^*	$10.14
Cost^*	$10.14

View all Promethazine prices

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Dosage Forms

Injectable solution
Oral concentrate
Oral tablet

Injectable solution
Oral syrup
Oral tablet
Rectal suppository

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

31 hours

16 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 730 drugs are known to interact with Chlorpromazine:

116 major drug interactions (452 brand and generic names)
598 moderate drug interactions (2486 brand and generic names)
16 minor drug interactions (58 brand and generic names)

A total of 689 drugs are known to interact with Promethazine:

94 major drug interactions (339 brand and generic names)
580 moderate drug interactions (2373 brand and generic names)
15 minor drug interactions (60 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using chlorproMAZINE together with alcohol. This can cause uncontrollable... View more

Ask your doctor before using promethazine together with alcohol. This can cause uncontrollable... View more

Disease Interactions

First Approval Date

November 20, 1957

March 29, 1951

WADA Class View classifications

N/A

More Information

Patient Resources

Chlorpromazine uses

Promethazine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Chlorpromazine vs Promethazine

See also:

Vraylar

Abilify

Rexulti

Seroquel

Zofran

Depakote

Ativan

Benadryl

Zyprexa

Latuda

Further information

Comparing Chlorpromazine vs Promethazine

See also:

Further information

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