Comparing Amantadine vs Sinemet
| Amantadine Remove Amantadine from your drug comparison | Sinemet Remove Sinemet from your drug comparison |
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| Amantadine Remove Amantadine from your drug comparison | Sinemet carbidopa / levodopa Remove Sinemet from your drug comparison | ||||||||||||||||
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Prescribed for Extrapyramidal Reaction, Parkinson's Disease, Influenza, Influenza A. May also be prescribed off label for Chronic Fatigue Syndrome, ADHD, Fatigue, Head Injury, Influenza Prophylaxis,... View more |
Prescribed for Parkinson's Disease, Neuroleptic Malignant Syndrome, GTP-CH Deficiency. May also be prescribed off label for Restless Legs Syndrome. |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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7.1
For Parkinson's Disease: Works to stop Dyskinesia caused by senement/dopamine pills |
7.7
For Restless Legs Syndrome: I have been taking sinemet for many years for restless legs (RLS) and it's the only thing that works. I developed severe RLS after having guillain barre syndrome. None of the home remedies have any effect at all. I have had to increase the dose over time and take a dose at 6pm, 8pm and when going to bed. This gets me thru the night. Sometimes I need to take in the day before a meeting or a long drive or flight etc.. For Restless Legs Syndrome: I have had restless legs syndrome for years due to iron deficiency. I took Sinemet for about a year and it seemed to work great for me. However, I could not take the full or even half of the dose because it really made me feel drowzy the following day so I would break it up and take a very small piece of the pill. Also, if you don't go to bed after taking it and stay up for a while, it can have the adverse effect on you. Makes you really sleepy, but make your restless legs symptoms worse. Good Luck! |
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Drug Class |
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Side Effects |
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See the full amantadine side effects document. |
See the full Sinemet side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all amantadine prices |
View all Sinemet prices and generic prices |
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Generic Availability |
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Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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| Gocovri, Osmolex ER | Other carbidopa / levodopa brands include: Atamet, Duopa, Parcopa, Rytary, Sinemet CR | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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19 hours |
2.3 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
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Drug Interactions |
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A total of 124 drugs are known to interact with amantadine:
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A total of 318 drugs are known to interact with Sinemet:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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February 14, 1968 |
May 02, 1975 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Parkinson's Disease: Started Amantadine 4 weeks ago 200 mg per day. Noticed immediately occasional dizziness and diarrhea after every 100mg capsule, lost any desire to get up and do anything, Midway through the third week, I cut my dosage down to 100 mg capsule per day, taken every evening at 8 pm before bedtime and that helped me sleep better and as well increased movement in arms and right leg and foot. Happy to say I am very pleased with the results!