Comparing Amantadine vs Sinemet

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Amantadine

Sinemet carbidopa / levodopa

Amantadine may be used to treat dyskinesia or reduce the number of OFF episodes in those with Parkinson's disease (PD) OR in the treatment or prevention of Influenza A viral infection. Nausea... View more

Sinemet is a medication that may be used for the treatment of Parkinson's disease that is available in three different strengths: Sinemet 25-100, Sinemet 25-250, and Sinemet 10-100. Dyskinesias... View more

Prescription only

See the full Sinemet side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	50 each
Dosage	100 mg
Per Unit^*	$0.75
Cost^*	$37.63

View all amantadine prices

Quantity	100 tablet
Dosage	10 mg-100 mg
Per Unit^*	$1.18 - $1.23
Cost^*	$118.08 - $123.40

View all Sinemet prices and generic prices

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Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available

Oral capsule
Oral syrup
Oral tablet

Oral tablet

Brand Names

Gocovri, Osmolex ER Other carbidopa / levodopa brands include: Atamet, Dhivy, Duopa, Parcopa, Rytary, Sinemet CR

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

19 hours

2.3 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 125 drugs are known to interact with amantadine:

7 major drug interactions (58 brand and generic names)
104 moderate drug interactions (588 brand and generic names)
14 minor drug interactions (49 brand and generic names)

A total of 465 drugs are known to interact with Sinemet:

10 major drug interactions (23 brand and generic names)
433 moderate drug interactions (2975 brand and generic names)
22 minor drug interactions (136 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and... View more

Disease Interactions

First Approval Date

February 14, 1968

May 02, 1975

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Patient resources

N/A

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer