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Zepbound User Reviews & Ratings (Page 2)

Zepbound has an average rating of 8.8 out of 10 from a total of 431 reviews on Drugs.com. 82% of reviewers reported a positive experience, while 2% reported a negative experience.

Reviews for Zepbound

Commonly mentioned side effects
  • Ada...
  • Taken for 1 to 6 months
  • January 2, 2025

For Weight Loss (Obesity/Overweight) "I'm 41, 6'2", 370.2 lbs. I started Zepbound on Dec. 1, 2024. The first couple of weeks, I had pain in my upper back, not overwhelming but constant for a couple of days. This really did take away my hungriness to eat, but did not limit what I could eat. So I got full quickly, even off the smallest amount of food filled me for the whole day. In doing this, I wanted to eat quick little things like snacks, then cause making a big meal was pointless. I had to rethink what I ate and form better habits. Now, don’t get me wrong, I still have a piece of candy or a few chips here and there but much better portion sizes. I haven't got all the stomach pains I've heard about or food rumbles. Bathroom issues are minimal. I figured since I'm taking in so much less, that much less will come out. It is now Jan. 2, 2025, and I have lost 23 lbs. This is with no extra exercise or anything more than the shot and listening to my body when it tells me I'm full. If I'm not hungry, I don't eat. So far, this is going great."

10 / 10
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  • Mar...
  • Taken for 6 months to 1 year
  • January 23, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound in April and have done really well with very little side effects. I've lost 45 pounds, but when I started to increase the dose up to 15 mg, I started having bad side effects: choking and coughing at nighttime, couldn't breathe, and now I think I have a stomach bleed because of it. I have since gone off of it because of the side effects."

8 / 10
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  • meg...
  • Taken for 1 to 2 years
  • July 1, 2025

For Weight Loss (Obesity/Overweight) "I have found Zepbound to be a miracle drug and a life changer! I have lost 113 lbs in 18 months. I am 9 lbs from achieving my goal weight and BMI. I will say that in the first 4-6 weeks I had some side effects - mostly that it was hard to find any food that was appealing. I only experienced stomach and intestinal issues if I overate or if I had food that was very high in fat. When I cut those items from my diet and regulated the size of my meals, I no longer had any issues. My insurance forced me to change over to Wegovy, and I will say I am having very severe stomach and intestinal issues with this medication and it has increased in severity over time. In the past week, I have been barely able to eat at all. I just started a new job and am hoping the new insurance will allow me to go back on Zepbound. I wish everyone out there who needs this type of medication to regulate their appetite all the best! I know we have suffered so much with fat-shaming blame. We deserve to be healthy!"

10 / 10
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Frequently asked questions

  • Pau...
  • Taken for 1 to 6 months
  • August 10, 2025

For Weight Loss (Obesity/Overweight) "I have just finished my first month of 2.5 mg and have increased the dose to 5 mg. This past Friday was the first time I have taken the 5 mg dose. Twenty-four hours after taking the shot on Friday am, I start a time of liquid diarrhea and stomach cramps that seems to completely clear my system from anything I have eaten in the last couple of days. After the ~24-hour period, the diarrhea subsides, and I feel like my system has rejected all food or nutrition that has been consumed. My appetite is definitely reduced from taking the shots, but I think the mental part of this battle is the biggest challenge for me. My wife has been on this program for a couple of years now and has said that the shots offer some type of chemical balance, and imbalance results that support or help change behavior. The amount that I eat at different times during the day will need to be addressed before I start seeing significant changes."

7 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 26, 2025

For Weight Loss (Obesity/Overweight) "Have had a lot of success with Zepbound at the low dose of 2.5 mg. I’ve lost about 30 pounds in four months. My biggest problem was abdominal distention. I’ve started drinking a quarter or half a glass of prune juice at night, and it’s really helping with my relief of constipation. I also think it’s helped with my stomach distention because I’m able to go to the bathroom every day."

10 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • August 2, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 18 weeks with a dosage of 5 mg. I have had constipation, stomach aches, afraid to eat anything at this point to avoid the problems I have been having. I admit I have lost 50 lbs as of this morning. I'm beginning to wonder though if the weight loss is worth all the misery I have been having and the very limited food I can eat. I honestly don't feel a great deal better like I thought losing this much weight would make me feel. The fact that it is now a lifetime commitment doesn't make it any better either. I don't think I can eat and feel this way the rest of my life."

5 / 10
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  • PRe...
  • Taken for less than 1 month
  • February 12, 2025

For Weight Loss (Obesity/Overweight) "On week number three, I started with stomach cramps and diarrhea. The night before, I had a huge helping of Boom Chicka Pop kettle corn. While the packaging states it only uses cane sugar, I came to the conclusion that this product (perhaps in the amount eaten) suddenly didn’t agree with me while taking Zepbound. I’ve lost 5 lbs in 2 1/2 weeks. Diarrhea and cramping subsided after 36 hours."

8 / 10
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More FAQ

  • Joa...
  • Taken for less than 1 month
  • November 10, 2024

For Weight Loss (Obesity/Overweight) "I'm a 64-year-old woman. 5'2" and weighed 177. I've lost 10 pounds in my first 3 weeks. With the heartburn, I had to force myself to eat last night when I wasn't really hungry. I think I ate the scrambled eggs too late in the evening. I had horrible diarrhea and vomiting. That was the first time that happened. I'm hoping it's just because I ate so late on such an empty stomach. I have had no desire to eat the first 3 or 4 days after injection. I have to remind myself to eat something."

8 / 10
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  • Ano...
  • Taken for 6 months to 1 year
  • July 17, 2025

For Weight Loss (Obesity/Overweight) "I have had good results with a 20% drop in weight in one year. Only occasional injection site redness. Occasional random stomachache not severe. Burping is significant. Occasional reflux. It helped with my hunger and feeling full quick. Gave me the strength to push away my plate and not gorge until it was all gone. Now my portions are much smaller. I feel my body adjusts to the dose rather quickly and then by the end of the week, I am starting to feel hungry again. This is the reason I scored it an 8."

8 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • July 9, 2025

For Weight Loss (Obesity/Overweight) "So far the experience for me has been difficult. The weight loss is slow but pretty much steady. I’m experiencing nausea, stomach pain, and fatigue. I’m still trying to stick it out, hoping that it will subside."

7 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 2, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "I thought it would curb my appetite more than it did. I have a lot of gas, and sour stomach gas. I haven't seen a lot of weight loss as of yet. Only 10 pounds in 2 months. Maybe this is what it's supposed to do. Giving it another try and doing better with my food choice. Wish me luck."

6 / 10
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  • hel...
  • Taken for 6 months to 1 year
  • November 20, 2024

For Weight Loss (Obesity/Overweight) "I started taking this in March 2024. I've had some weight loss (about 30 pounds), but not as much as I anticipated. I occasionally experience nausea and stomach pain, but it's usually after a very fatty meal (avoiding those types of foods minimizes this symptom for me). When I reached the 10 ml dose, I began having an itchy, raised red area surrounding the injection site that dissipates by the end of the week. I had one shot that didn't dispense the needle until I held it up to inspect it. I am happy I started this medication because I did lose weight (and hopefully will continue to) and was able to stop taking metformin! The worst thing about taking this medication is trying to get the prescription filled. I have had more issues trying to get my refills for Zepbound than any prescriptions for opioid pain medication (which I have taken in the past post-surgery due to an allergy to acetaminophen). At first, it was supply issues. Now it's preauths and difficulty staying at a certain dose."

8 / 10
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  • KDa...
  • Taken for 1 to 6 months
  • May 7, 2025

For Weight Loss (Obesity/Overweight) "Works well. I cannot take the shot in my stomach, too much bloating and very uncomfortable. I am now on 10 mg and now having an issue with my hair breaking and thinning. It’s apparently just temporary. Fingers crossed!"

9 / 10
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  • Dai...
  • Taken for 6 months to 1 year
  • September 28, 2024

For Weight Loss (Obesity/Overweight) "I began Zepbound in March 2024. Previously to Wegovy, but weight loss had stalled on 1.7, and higher doses had lots of quality of life side effects that prompted a change. Began 2.5 Zepbound, and weight loss has been very slow. Have lost 10 lbs since March. Currently on 10 and moving up to 12.5 next week. I have had minimal discomfort on Zepbound. Food noise has subsided. Appetite is very manageable. The past two weeks, I've had injection site redness. Have been injecting in my stomach until this week, thinking the belly area may need a rest. Injected in my thigh and noticed today that the area has a quarter-size red spot. Zepbound has been a painless medication to inject. I was concerned about injecting near my belly button, as the last medicine was uncomfortable. Overall, good experience as far as side effects go, but weight loss has been slow. I took Wegovy from March 2023 to December 2023 and lost 60 lbs. I need/want to lose an additional 40 lbs. I'm a 62-year-old CF, beginning weight was 264 lbs, current weight 194."

8 / 10
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  • Aut...
  • Taken for 6 months to 1 year
  • March 3, 2025

For Weight Loss (Obesity/Overweight) "I am 45 years old and female. I have been on Zepbound for eight months. I started at 275 lbs and am now at 235 lbs. The day after I first took it, my stomach was so full it hurt, just from my normal portion sizes. Over time, the dosage has increased to 7.5. I am a little more tired than usual, but that's a small price to pay. The vast majority of side effects occur when I overeat. There's no way to know which of these I will have then: pain in my stomach, egg burps, loud flatulence, and/or diarrhea. I have been sick a lot more than usual, along with swollen lymph nodes and hoarseness, but there's no way to know if they're related or not."

9 / 10
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  • ck6...
  • Taken for 1 to 6 months
  • December 16, 2024

For Weight Loss (Obesity/Overweight) "I am currently taking the 7.5 mg. I have currently lost 35# since I started my journey 7/2024. I have noticed that I can barely eat anything, feel very full after a few bites of food. To the point where I feel like vomiting and have a burning feeling like when you eat Halls cough drop, the menthol cool burn feel in my stomach and throat. It's NOT heartburn, it's different. Constantly thirsty, severe cotton mouth, especially at night."

10 / 10
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  • Dan...
  • Taken for 1 to 6 months
  • August 13, 2025

For Weight Loss (Obesity/Overweight) "I was taken Zepbound and have been vomiting, heart rate up, lack of water in my body, and been to the hospital three times because I keep throwing up. So what can I do and how long before it’s out of your body? It’s like the doctor doesn’t know what to do about the side effects of this drug from March until July. Off the seven point five mg got me all sick. Can't keep anything on my stomach."

10 / 10
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  • tri...
  • Taken for 6 months to 1 year
  • September 2, 2025

For Weight Loss (Obesity/Overweight) "After taking this medication since February of 2025 and currently being at a 10 mg dose, I can say I got a ton of side effects and still do. I get injection site reactions I'm told to ignore because it was swelling but now is just itchy. I get constipation and the urge to go poop even when I don't have to go. Stomach aches are killer and literally leave me lying in bed unable to move. But symptoms are worst during the weekend as I take my meds on a Friday. Leading me to be unable to make plans on Saturdays or Friday evenings. I have so far lost 35 lbs over these 7 months with minimal exercise and some healthy dieting. My goal weight is 160 and I'm currently 255 down from 290 starting weight. I'm down 10% body fat. The longer I stay on my current dose, the less I feel the intensity of the symptoms, but I also still have appetite issues. As in I'll eat, and an hour later I'll be hungry again because I was unable to fill myself earlier. Or I wake up in the middle of the night to eat."

8 / 10
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  • Tri...
  • Taken for 1 to 6 months
  • September 3, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for a month now, lowest dosage of 2.5 mg, and today I'm to start my second month with the next dosage up, but personally, I'm done. I've lost 7 pounds this August 2025, and though it may not seem like a lot to most people, it's quite something to those of us who have a very hard time losing weight. The thing is, how can a person be happy with the weight loss when you're miserable all the time? My first week went well, but come the second, the stomach aches/cramps and nausea are too much... every day, all day, through the night... sicker than a dog. I've heard good things about Zepbound, but the side effects are just too much for anyone to feel good about the journey it takes you on, and if the side effects only get worse with the higher dosages, then I might as well not eat at all for what little I can now, when I can. I'm 300+ pounds, and this was my last hope for any type of weight loss help. I don't recommend this product, the side effects outweigh any of the happy."

3 / 10
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  • Boi...
  • Taken for 1 to 6 months
  • May 30, 2025

For Weight Loss (Obesity/Overweight) "I am a 67-year-old male. I have been taking Zepbound for 3 1/2 months now. Currently taking the 7.5 strength. I have just reached the 50 lb threshold or just under 20% of my body weight lost. The drug is not a magic potion as you still have to eat the right calorie foods, but the drug makes it much easier as I am really never very hungry and fill up quicker. My biggest struggle has been wanting to snack at night from boredom. As for side effects, I belch more, early on, I experienced some upset stomach but found if I eat a few crackers with peanut butter, I feel a lot better. I also experience some constipation, but my doctor said that was mainly due to the reduced amount of calories I am consuming. Overall, I am thrilled with the experience and results. I plan on losing another 5-10 pounds, then work on maintaining new eating habits. My doctor suggested I order some extra of the 5 strength and keep it back to take if I start sliding back into old eating habits. I plan on doing that."

10 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 22, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound five weeks ago. I started with 2.5. My first couple of weeks were fine, but by my third week after that shot, I could not eat for 3 days. I tried even sipping on water and couldn't because of the nausea. My throat kind of burnt all the way down to my stomach, it felt like someone was squeezing the top of my throat. I just took my first shot of the 5.0 3 days ago, and I still haven't been able to eat because I'm so nauseous, and again my stomach's hurting. I tried yesterday to take some Rolaids, but that made me throw up. I haven't told my doctor, and I'm still going to continue taking it, but if this keeps up, it's not worth it. But I will continue to try maybe one or two more weeks, but if it just keeps up and is this miserable, I'm going to stop taking it. Hopefully, no one else has this feeling. But I didn't lose 19 lb in one month. I hope everyone does better on it than I am."

8 / 10
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  • Ros...
  • Taken for 1 to 6 months
  • June 28, 2025

For Weight Loss (Obesity/Overweight) "Raised red swollen area around injection site. Itchy stomach pain."

5 / 10
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  • Ano...
  • Taken for less than 1 month
  • May 27, 2025

For Weight Loss (Obesity/Overweight) "Just got started, currently in my 3rd week. Moderate to severe diarrhea started after the 3rd shot. No nausea at this point. Some stomach pain."

5 / 10
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  • Los...
  • Taken for 1 to 6 months
  • October 2, 2024

For Weight Loss (Obesity/Overweight) "I’ve been taking Zepbound for about 11 weeks and have lost about 20 lbs. The only real side effect that is uncomfortable is gaseous stomach, mostly occurring when I eat too fast."

9 / 10
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  • Ano...
  • Taken for less than 1 month
  • April 16, 2025

"Zepbound decreased my appetite. But after 2 weeks, I am ready to abandon it because of stomach cramping."

8 / 10
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