Zepbound and Constipation: What Users Say

• foo...
• Taken for 1 to 6 months
• July 22, 2024

For Weight Loss (Obesity/Overweight) "I've been on this medication for 6 weeks and have never felt better about my body or my day. I didn't realize I could have a day where I wasn't thinking about food from the minute I got up until I fell asleep at night. I feel free to think about other things and to not be distracted by trying to have willpower to not eat. It's a huge relief. Is this what thin people feel like? People who have never struggled with being overweight? I have always thought my weight was based on my genetics, and maybe it is-but it's also my brain that literally is addicted to food. It feels like I've been released from an addiction. I haven't noticed any side effects. I tried Ozempic before this and was very constipated and had stomach issues. I don't feel that way at all on Zepbound, my stomach is fine. I'm on 2.5, it's very easy to administer, and I feel like it really works. I hope I'm able to take it for a long time, I'm sort of afraid to go back to the brain I had before taking it."

• Anonymous
• Taken for 1 to 6 months
• February 16, 2025

For Weight Loss (Obesity/Overweight) "My side effects are constipation, headaches, vision is foggy, insomnia, stomach pain, nervousness, dehydration, frequent urination, bumps on my labia. It is very easy to use. I have lost 14 pounds in two months. It does cut your hunger."

• 2go...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "On week 5 of Zep. Goal to lose 20-25 lbs. Received a 2.5 mg 'loading' dose, I split it into 1.25 doses 3 days apart for the first 2 weeks as I tend to react strongly to meds. I had a bit of anxiety and fatigue on this dose and appetite suppression that waned by week 2, so I increased to 2.5 in one shot for weeks 3 and 4. Less anxiety/fatigue but more nausea and constipation, still manageable. I received a 5 mg dose in the mail at week 4 but had already lost 15 lbs on the 2.5 dose for 4 weeks. Week 5 - I tried the 5 mg. The next day, I was so sick to my stomach and nauseous that I struggled to eat or drink at all. I was dizzy and felt terrible, depressed, and kept getting the long bouts of hiccups. I will be at goal soon and plan to switch to metformin to maintain weight. For me, this med is miraculous, but I do not feel great on it. (For reference - I have a mental health diagnosis and pre-existing mild gastrointestinal issues, MTHFR gene variant)"

• Ano...
• Taken for 1 to 6 months
• June 26, 2025

For Weight Loss (Obesity/Overweight) "Have had a lot of success with Zepbound at the low dose of 2.5 mg. I’ve lost about 30 pounds in four months. My biggest problem was abdominal distention. I’ve started drinking a quarter or half a glass of prune juice at night, and it’s really helping with my relief of constipation. I also think it’s helped with my stomach distention because I’m able to go to the bathroom every day."

• Ano...
• Taken for 1 to 6 months
• August 2, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 18 weeks with a dosage of 5 mg. I have had constipation, stomach aches, afraid to eat anything at this point to avoid the problems I have been having. I admit I have lost 50 lbs as of this morning. I'm beginning to wonder though if the weight loss is worth all the misery I have been having and the very limited food I can eat. I honestly don't feel a great deal better like I thought losing this much weight would make me feel. The fact that it is now a lifetime commitment doesn't make it any better either. I don't think I can eat and feel this way the rest of my life."

• tri...
• Taken for 6 months to 1 year
• September 2, 2025

For Weight Loss (Obesity/Overweight) "After taking this medication since February of 2025 and currently being at a 10 mg dose, I can say I got a ton of side effects and still do. I get injection site reactions I'm told to ignore because it was swelling but now is just itchy. I get constipation and the urge to go poop even when I don't have to go. Stomach aches are killer and literally leave me lying in bed unable to move. But symptoms are worst during the weekend as I take my meds on a Friday. Leading me to be unable to make plans on Saturdays or Friday evenings. I have so far lost 35 lbs over these 7 months with minimal exercise and some healthy dieting. My goal weight is 160 and I'm currently 255 down from 290 starting weight. I'm down 10% body fat. The longer I stay on my current dose, the less I feel the intensity of the symptoms, but I also still have appetite issues. As in I'll eat, and an hour later I'll be hungry again because I was unable to fill myself earlier. Or I wake up in the middle of the night to eat."

• Boi...
• Taken for 1 to 6 months
• May 30, 2025

For Weight Loss (Obesity/Overweight) "I am a 67-year-old male. I have been taking Zepbound for 3 1/2 months now. Currently taking the 7.5 strength. I have just reached the 50 lb threshold or just under 20% of my body weight lost. The drug is not a magic potion as you still have to eat the right calorie foods, but the drug makes it much easier as I am really never very hungry and fill up quicker. My biggest struggle has been wanting to snack at night from boredom. As for side effects, I belch more, early on, I experienced some upset stomach but found if I eat a few crackers with peanut butter, I feel a lot better. I also experience some constipation, but my doctor said that was mainly due to the reduced amount of calories I am consuming. Overall, I am thrilled with the experience and results. I plan on losing another 5-10 pounds, then work on maintaining new eating habits. My doctor suggested I order some extra of the 5 strength and keep it back to take if I start sliding back into old eating habits. I plan on doing that."