Zepbound and Nausea: What Users Say

• Xer...
• Taken for 1 to 6 months
• May 21, 2025

For Weight Loss (Obesity/Overweight) "Second review. I'm male, 75 years old. Began taking 2.5 mg on January 12, 2025. Today is May 21, 2025. Weight dropped from 268 to 232.5 (35.5 lbs). Went to 10 mg on May 8. Took 2 weekly 10.0 doses in that time period. Suddenly, explosive diarrhea, sulfur burps, nausea, and fatigue began May 18. My PA has advised not taking my 10.0 injection tomorrow (my regular day). Think I may need to drop back to 7.5 — had no side effects at that level (or at 2.5 or 5.0). Had already decided not to go to 12.5 because I have a friend who was fine on 10.0 but encountered major side effects at 12.5. Still, even 10.0 may not be right for me. The weight loss is stunning; haven't been at this level in over five years — but for a BMI of 25, I still have over 70 lbs to go, so I don't want to abandon Zepbound altogether. It may take longer to get there, but that's fine if it means I can avoid side effects."

• SdS...
• Taken for 1 to 2 years
• February 13, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost a full year. I lost weight quickly: 90 pounds. I was at my goal in 6 months. I had to go back 2 doses to maintain and stop losing weight. The nausea has not stopped. It’s better than in the beginning, but I still get it every time for 1 or 2 days after a shot. The diarrhea is terrible. It has never stopped. I get it on day 2, and it is uncontrollable. It’s been almost a year, so I would think some of these side effects would have stopped, but they haven’t. I also get sulfur burps for a day or 2 after a shot. I’m at the point where I might have to stop taking it due to the side effects. I love the weight loss, and I sure don’t want to gain it back, though."

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

For Weight Loss (Obesity/Overweight) "I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• Me1...
• Taken for 1 to 6 months
• March 7, 2025

For Weight Loss (Obesity/Overweight) "I started off with 2.5 mg the first month. Second month is 5 mg. Today I take the 3rd needle from the package. Last night was the first time I was nauseous and vomiting. I don't know if it was from the medication, but that day I had eaten chips and chocolate. I had not since I started. I want to believe eating those led me to being sick. Burping started about 3 weeks ago but only lasts for a day. It has happened 3 times. Been stuck on the same weight for 2 weeks."

• Mor...
• Taken for less than 1 month
• July 21, 2025

For Weight Loss (Obesity/Overweight) "So far, so good. I am suffering from the nauseated feeling, burping, fatigue, and muscle cramps. I'm at 2.5 level, week 3. I'm definitely eating a lot less."

• Suz...
• Taken for 1 to 6 months
• January 23, 2025

For Weight Loss (Obesity/Overweight) "Encounter burping, nausea, and can’t fall asleep easily."

• Vio...
• Taken for 1 to 6 months
• November 24, 2024

For Weight Loss (Obesity/Overweight) "For the most part, my biggest side effect has been burping and nausea. Even before using this medication, I had bouts of reflux."