Zepbound and Diarrhea: What Users Say

• SdS...
• Taken for 1 to 2 years
• February 13, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost a full year. I lost weight quickly: 90 pounds. I was at my goal in 6 months. I had to go back 2 doses to maintain and stop losing weight. The nausea has not stopped. It’s better than in the beginning, but I still get it every time for 1 or 2 days after a shot. The diarrhea is terrible. It has never stopped. I get it on day 2, and it is uncontrollable. It’s been almost a year, so I would think some of these side effects would have stopped, but they haven’t. I also get sulfur burps for a day or 2 after a shot. I’m at the point where I might have to stop taking it due to the side effects. I love the weight loss, and I sure don’t want to gain it back, though."

• SMP...
• Taken for 6 months to 1 year
• February 5, 2025

For Weight Loss (Obesity/Overweight) "I’ve lost 43 lbs in the last 9 months. I experienced some mild hair loss (but started this in menopause, so that contributed to hair loss as well), increased heart rate, although mine was low to start, some burping, and tiredness. The worst side effect for me is the diarrhea. I have it starting about 24-48 hrs after injection. It lasts on and off for about 3 days. Overall, these side effects have been mild and manageable. The weight loss has been life-changing!!"

• JWa...
• Taken for 1 to 6 months
• March 28, 2025

For Weight Loss (Obesity/Overweight) "Zepbound was effective within the first week. I experienced a significant decrease in hunger and decreased interest in food. I also found that I could not always finish a meal serving in one sitting. Initially, I had minor issues in bowel habits (constipation and diarrhea). Both symptoms are minor and managed with adequate hydration and fiber-rich foods. More disconcerting have been the “egg burps” caused by bacterial action on sulfur-rich foods in a slowed GI system. I have selected less sulfur-rich foods and make a concerted effort to drink more water during a day or two following the weekly injection. This side effect seems to have moderated, perhaps as I am into the second month of my current dosage and third month on Zepbound and/or temporarily minimizing sulfurous food intake in a short period following injection. I also track my food intake and assure I am eating an adequate level of protein. I have lost 15 pounds in 10 weeks. I am 77 and a woman."

• 1 d...
• Taken for 1 to 6 months
• July 18, 2024

For Weight Loss (Obesity/Overweight) "I have had zero issues with the drug when I do right. If I overeat, I have diarrhea and sulfur burps for sure. When I start my day with protein and coffee, and drink lots of water, I have zero issues. But if I mess up like I did this week (ate breakfast, lunch, happy hour, snacked), I was up all night in a world of hurt, and I still haven't fully recovered. I haven't noticed a significant weight loss in 5 weeks (10 pounds), but it’s been steady. Just DO NOT OVEREAT and drink plenty of water."

• Aut...
• Taken for 6 months to 1 year
• March 3, 2025

For Weight Loss (Obesity/Overweight) "I am 45 years old and female. I have been on Zepbound for eight months. I started at 275 lbs and am now at 235 lbs. The day after I first took it, my stomach was so full it hurt, just from my normal portion sizes. Over time, the dosage has increased to 7.5. I am a little more tired than usual, but that's a small price to pay. The vast majority of side effects occur when I overeat. There's no way to know which of these I will have then: pain in my stomach, egg burps, loud flatulence, and/or diarrhea. I have been sick a lot more than usual, along with swollen lymph nodes and hoarseness, but there's no way to know if they're related or not."

• Ama...
• Taken for 1 to 2 years
• March 19, 2025

For Weight Loss (Obesity/Overweight) "I have lost nearly 80 lbs over the past 20 months. My A1c has improved greatly, as has my sleep apnea. My weight has remained stable at 152 lbs over the past 6 months, and I am able to resume skiing and hiking! I can keep up with my peers again! I have made major life changes with my diet/eating and resuming regular exercise, and I look forward to maintaining a healthier lifestyle for the rest of my life! I experienced uncomfortable diarrhea, gas, and unpleasant burping initially, which resolved. I also experienced hair thinning, but not severe. I now have a somewhat flattened butt, which I have read is known as Ozempic or Zepbound butt, and am working on weight training exercises to rebuild muscle in my legs, glutes, and arms. I would not recommend this drug to anyone who is not able or willing to put in the hard work of developing lifestyle changes and including exercise and diet, due to the muscle loss factor."