Tirzepatide for Weight Loss (Obesity/Overweight) User Reviews (Page 5)

• Ano...
• Taken for 1 to 6 months
• May 14, 2025

"I started on Friday, March 21, and had no side effects for the first two weeks. Then I overate cheesy pasta and had severe diarrhea. The next 10 days, I had three more episodes of diarrhea and vomiting. And severe fatigue. I was not able to continue my exercise routine as often as usual. The fatigue after minimal activity was interfering with my life. I cannot walk more than a few blocks. I stopped the injections three weeks ago, and for the most part, I have intermittent fatigue. It apparently takes about 25 days for the med to be out of the system. I lost 9 pounds after the first 3 or 4 weeks and have not gained them back. I didn't have quite the same separation of thoughts of food as I had expected. Hopefully, only another week or two to get my energy back."

• JWa...
• Taken for 1 to 6 months
• March 28, 2025

"Zepbound was effective within the first week. I experienced a significant decrease in hunger and decreased interest in food. I also found that I could not always finish a meal serving in one sitting. Initially, I had minor issues in bowel habits (constipation and diarrhea). Both symptoms are minor and managed with adequate hydration and fiber-rich foods. More disconcerting have been the “egg burps” caused by bacterial action on sulfur-rich foods in a slowed GI system. I have selected less sulfur-rich foods and make a concerted effort to drink more water during a day or two following the weekly injection. This side effect seems to have moderated, perhaps as I am into the second month of my current dosage and third month on Zepbound and/or temporarily minimizing sulfurous food intake in a short period following injection. I also track my food intake and assure I am eating an adequate level of protein. I have lost 15 pounds in 10 weeks. I am 77 and a woman."

• Ano...
• Taken for 1 to 6 months
• April 19, 2025

"Began 1 month ago, March 2025, starting with 2.5 mg at 210 lbs, and I am 5'4", size 14. 2nd month, same dosage, 2.5 mg. Now my weight is 183 lbs, size 10. I do have nausea, but it goes away when I drink plenty of water/seltzer. I can eat what I want, but small portions, and I can put the fork down. I take the shot at bedtime. I have only used my arms. It does not hurt. I am happy this is working."

• Lin...
• Taken for 1 to 6 months
• December 5, 2024

"I started taking Zepbound on the first of September, am 5'8, was weighing 190. I stopped taking Zepbound on November 18th, had no serious side effects, I was just feeling moody. Stopped at my goal of 175.9 and still losing on my own. It's December 5, and I weigh 172.9. Zepbound has taught me to eat a balanced, healthy meal without all the cravings, portion size, and exercise. Down 16 pounds."

• R S...
• Taken for 6 months to 1 year
• December 31, 2024

"I've been on Zepbound for 6 months, and it has worked great for me! 40 lbs. down!!! I only feel yucky the day after the injection, but other than that, no other concerns. I just received a letter from my insurance company (Keystone East) stating that beginning 1/1/2025, IBX in whole is no longer covering weight loss drugs. WOW!!!! :( People like myself have been waiting most of their lives for a drug like this, and here we go with corporate America. Even though I'm 40 lbs. down, I still need to lose an additional 40 lbs. just to be considered overweight and not obese in the medical world. My joints no longer hurt, and I can work out without the aches and pains. My overall health has improved so much, and I am greatly disappointed and upset with this decision from IBX. I wish everyone much luck if this will be happening to you too after the new year."

• She...
• Taken for 1 to 6 months
• February 10, 2025

"I started in October and am now on 10 mg. I have lost 106 lbs. I feel better than I have in years. I’m 69 and will be 70 in August. I do more, I get out more, I’m involved again. I have 60 more to go. I’m not saying it’s been a bed of roses, but the good outweighs the bad days 95%. Also, in the beginning, I would give myself the injection at night and then take something for nausea my doctor prescribed and no longer felt nauseous. Good luck, everyone, to a longer and better life."

• Ill...
• Taken for 1 to 6 months
• February 14, 2024

"I have been on Zepbound for 6 weeks. (4 weeks 2.5) (2 weeks at 5.0) I have lost 23 lbs. 307-284 I ride bike/treadmill and lift weights. I eat 2300 calories a day. If I happen to eat too much, I don't seem to notice. But what I do notice is I don't crave food like before. Before, I used to still be hungry after dinner. Not anymore. That part of my brain that was ravenous for more is gone."

• Min...
• Taken for 1 to 2 years
• November 29, 2023

"I am a 61-year-old female. I have been overweight for over 20 years and also dealing with other health issues. I started taking Mounjaro just a little over a year. I started with 5mg in the first week and lost 9lbs in one week, then I increased to 7mg and continued to lose weight. Long story short, I am now on 15mg and I have lost a total of 90lbs, from 339 to 247. This is unbelievable. I too have to make myself eat, like other reviews have stated. I feel so good. I have had 3 major back surgeries within the past 3 years. My A1C was never good, but now it's perfect. I used to walk hunched over, and now my posture is perfect. I want to lose 50lbs or more but I am happy with the state I'm in. However, I will be extremely happy to lose some more weight. I am a living testament that these injections work, just like the thousands of other reviews are saying. Where was this medication 20 years ago?"

• Sho...
• Taken for 1 to 6 months
• April 25, 2023

"This medication is incredible. My cholesterol and blood pressure were borderline. My doctor suggested losing weight (I have had a weight problem my entire life), which was an ongoing life pursuit for me. Nothing lasted. I would end up feeling worthless and depressed. I started this medication in January 2023. Today is April 25th, and I have lost 36 pounds. My blood pressure is on its way down. My energy levels were stable throughout the day from week one, so it is not just the weight loss, the medicine has helped with my ADHD and my depression. The only side effect I have experienced was constipation, which I corrected by using small dosages of Miralax daily. I hope the FDA approves this medication for weight loss soon. It is a great tool to use along with healthy eating and exercise."

• dil...
• Taken for 1 to 6 months
• March 10, 2025

"I have been taking Zepbound for 4 weeks. I have lost 20 pounds. I am not hungry, no side effects, more energy, and I sleep so much better. I am on 2.5. I love this drug. I did not want to believe the good reviews or the bad ones, I just needed to know for myself, and now I do. It is great. Take a chance, you will see it really works."

• Vic...
• Taken for 6 months to 1 year
• December 4, 2023

"I have been diabetic and overweight for 20 or more years, along with several health issues and various medications. Thank God for my doctor and Mounjaro. I started at 2.5 and 204 lbs in March, with few side effects. It is easy to use. I am now on 5.0 and 64 lbs lighter, and my A1c is at 5.7. I can breathe better and go for walks more. I crave no sugar or carbs. I was miserable with no hope in sight. I will be going on the 7.5 with hopefully no side effects. Thank you Mounjaro and my doctor for giving me my life back."

• she...
• Taken for 1 to 6 months
• March 18, 2024

"I have been on Zepbound for two months and have lost only 9 pounds. I don't eat breakfast because I am not hungry, this has been a lifelong habit of mine. I am hungry at noon and eat more than I should. I have found that I am eating too fast, which is causing me to not have the weight loss that I would have if I ate slower. I have noticed that when I eat slower, I stop eating when I am halfway done with my meal. Hopefully, I can break a lifelong habit of eating fast. I have no side effects from the drug or overeating."

• mis...
• Taken for 1 to 6 months
• January 23, 2025

"I have had a good experience with Zepbound. So far, I have lost 30 lbs in 6 months. This is my take and experience. You will feel sick if you eat improperly. You're not going to lose weight and continue to eat like you have been. Butter, fat, oil, and overeating will make you feel nauseous. These drugs slow down your digestion. I learned that in the first 24 hrs. I was at a barbecue and piled the food on my plate like normal. I felt sick the rest of the day. I learned my lesson. Make sure you drink plenty of fluids. Since digestion is slower, other functions slow down too! (If you know what I mean). Don't starve yourself, that will make you feel sick too. I have found that avoiding too many carbs and eating high in protein is working for me. I'm hoping my brain is rewired for when I go off Zepbound. I don't plan on being on this forever."

• MTO...
• Taken for 6 months to 1 year
• May 14, 2023

"This medication has been a huge blessing in my life. Started at the lowest dose in August of 2022. Increased each month to the highest dose and have stayed there for 3 months now. It's May of 2023, and I have lost 80 pounds! I was pre-diabetic, depressed, and hopeless. I've had a bit of stomach upset, diarrhea, heartburn, gas... nothing terrible. But I feel so much better. My joints don't hurt hardly at all, I have more confidence to go places and talk to people and do stuff outside, and I even sleep better. I was looking into bariatric surgery before I found Mounjaro. I'm so glad I didn't have to do that."

• Tra...
• Taken for 1 to 6 months
• August 19, 2023

"I am just starting week 5. I started on 5mg, so today was my first 7.5. Last month, I lost exactly 20 pounds. I started at 222 and now I'm at 202 after 1 month. I get bad constipation, but nothing Dulcolax liquid can't fix. I drink 2 protein shakes a day, a handful of chicken, and some days I replace chicken with fruits and low-fat cottage cheese. I drink lots of water and have 1 coffee with only milk once a week. I can't wait until this time next month. It's definitely a game changer. I haven't been that active, but today I will start going to the gym 5 days a week. I will update next month."

• Jov...
• Taken for less than 1 month
• March 22, 2023

"So far, it's been great, no side effect whatsoever. I could say I'm not hungry at all, I eat out of habit but a very little amount of food. Since I'm not hungry, it allows me to make better food selections."

• Bor...
• Taken for 1 to 6 months
• January 17, 2025

"I’m almost 46. I have been struggling with weight loss all my life, joined food addiction programs, and tried other diets, and nothing worked. I lost some but gained it right back. I started at 220, but in numbers, I was not diabetic, so my insurance wouldn’t cover weight loss medication. My doctor worked with me for months and kept trying until it was finally approved. I did manage to get down to 186 pounds before starting on Zepbound. I have lost an additional 22 lb in 2.5 months! I’m at 164 now, and I haven’t been here in years. I can relate to many of the comments here. I don’t think about food, no cravings. I feel satisfied. I have been doing one meal a day, and I feel great. I don’t feel anxious, deprived, or hungry. I don’t worry about what I’m going to eat next. I don’t catch myself always snacking. It’s changed my brain in a way that I’m at peace. Just started on a 7.5 gm, and I did have some nausea just the very first day, but no other side effects."

• Pau...
• Taken for 1 to 2 years
• June 27, 2023

"I seem to have experienced almost every side effect except coma, and if I hadn't stopped taking the drug, I'm certain that my severe jaundice would have put me in a coma. I did lose a significant amount of weight but almost died in the process, and my tachycardia is still presenting..."

• Day...
• Taken for 1 to 6 months
• September 14, 2024

"Have been injecting Mounjaro weekly for a month now and have lost 4 kg, but here is what I learned… 1. Make sure you're fully hydrated before injecting the recommended dosage of the first 2 weeks, needles being 2.5 ml, as it dehydrates you big time and most of the time is why you are feeling nauseated, but keep hydrated, drink up. Eg. Powerade or Hydralytes… 2. Inject in the top thigh as it is less nausea feelings than injecting in the tummy. 3. Your body automatically tells you that you are full after a small portion of dinner (saucer plate size) as breakfast I craved Vegemite on thin bread, so maybe I was lacking either salt or B12 levels down. Lunch I ate a small amount too, but have snacks 4 times a day, even one sugar lolly made me feel better."

• 1li...
• Taken for 1 to 2 years
• April 14, 2024

"I just wanted to give an update on my success on Mounjaro. I've been on it for 18 months. I continue to lose weight slowly. No problem with the shot. I've lost a total of 118 pounds. I went from a size 22 to a size 2. I do Weight Watchers app online for the accountability. And walk 5-8 miles a day. My doctor thinks I should be her spokesperson in her office for the new patients going on it to give them motivation. But can't with HIPAA. I'm okay with her giving them my name and everything, but she can't. It's funny when I'm out in public and people are not sure if it's me or not. But it sure makes me feel good. I just know when people do ask how I've lost weight, and I tell them. I say with diet, exercise, and I have diabetes. I also take Mounjaro, but it's not a miracle drug."

• On...
• Taken for less than 1 month
• February 18, 2025

"With the initial injection of 2.5 taken before bed. I woke up with painful, swollen neck lymph nodes and extreme fatigue. The next day, the swollen lymph nodes seemed to have moved down, now in the chest/armpit area. On the 3rd day, one of my knees is swollen and horribly painful. I have absolutely never had any knee issues prior to the injection. If I get nauseous, drinking more water helps. At this start of the med, continuing is definitely not worth it."

• gle...
• Taken for 1 to 2 years
• April 29, 2025

"I am 56 years old and I weighed 343 lbs, and my height is 6 ft. tall when I asked my doctor about using Mounjaro. I was a type 2 diabetic. I wore a size 50 pants and a 4 XL shirt. Started Mounjaro a year and six months ago along with a low carb diet. I walked on the treadmill 1 to 3 miles 3 times a week. As of today, I've lost 134 lbs and wear a size 32 to 34 pants. My shirts are large to extra large. I am able to jog and not walk. My A1c is 4.5 to 5.4, down from 7. All around better quality of life thanks to Mounjaro. I wished there was a way to post my pictures of my before and after on here. But I just wanted to share, and if my 56-year-old self can do it, anyone can. God bless."

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

"I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• Kim...
• Taken for 1 to 6 months
• March 28, 2023

"I feel amazing on Mounjaro. I feel as though my body is “back in tune,” and the weight comes off steadily. I’m just never hungry, but I do eat. It doesn’t take much for me to feel full once I do eat. 23 pounds lighter and 10 more to go."

• Dav...
• Taken for 1 to 6 months
• September 17, 2024

"I started at the beginning of May 2024 at a weight of 236. My doctor recently retired, and I was seeing his PA, and he started me on Zepbound 2.5 for a month. I had lost several pounds and moved to 5.0 mg, which I am still on, today is September 17. The PA and I agreed that this dose seems to be working well for me - today, I am 186 pounds! This medication is amazing! I have had no side effects at all."