Tirzepatide for Weight Loss (Obesity/Overweight) User Reviews (Page 4)

• mje...
• Taken for 1 to 6 months
• May 9, 2024

"I originally started the Zepbound shot at the end of this past January. I weighed a total of 202 lbs when I started it. That would be about 3-4 months ago. I was very self-conscious, I didn't want to take any pictures of myself, I felt disgusted by myself, I always brought myself down, etc. But now, now I weigh 154 lbs. I'm at the 10 mg of the Zepbound. I started off as the lowest and I'm still not at the highest, to be honest. I lost about 50 pounds in the last 4 months! I researched it and it'll take 16 months to lose about 50 pounds for a normal person who doesn't take anything. And I did it in 4 months with that shot! I never thought I would get to this weight, to be honest. In the beginning, I was going to the YMCA to work out every week to put in the extra work, etc. At first, I started losing like a pound a day, not even kidding, sometimes 2 lbs a day. Then it went to a pound every couple days, and it would vary."

• Ano...
• Taken for 1 to 6 months
• May 28, 2025

"I love Zepbound. I was on Wegovy prior to switching to Zepbound and lost 20 pounds in 6 months. I was nauseous, fatigued, and dizzy for 3-4 days after taking my shot. However, on the Zepbound, I have no side effects other than slight pain at the injection site for 2-3 minutes after I take my shot. After switching to Zepbound, I lost another 20 pounds in just 3 months."

• bae...
• Taken for 1 to 6 months
• March 18, 2024

"Absolutely life-changing. For the first time in my life, I'm satisfied by reasonable portions. I'm not always thinking about the next thing that I'll be eating. I'm able to feel and respond to my actual hunger cues without my scarcity brain taking over. Even if I wasn't losing weight, the relief of food obsession and binge eating disorder would be worth it. Four weeks in, down 13 lbs and very satisfied. Only side effect has been feeling cold and some mild constipation."

• Bye...
• Taken for 1 to 6 months
• July 23, 2025

"Lifelong dieter here. Despite successes, the weight always crept back. Zepbound feels like a game changer thus far. I feel fabulous overall. Nobody knows of my decision to try Zep, yet already everywhere I go people comment on how healthy I look. I’m 73 years old, female, 5’6”, SW 185 and goal 145. I’m on my fifth week @2.5, with a steady loss of 2 lbs per week. Minor nausea on injection day with the abdominal injection. The tartness of gummy fiber/vitamins is great for relieving nausea. Periodic fatigue mostly on day two. Friday is injection day so I can crash on Saturday if necessary. I eat six small meals each day and try to get a total of 120-140 grams per day. I get food noise, but it’s good noise thinking about nutrient-dense and low-cal foods. Protein/collagen powders/snacks are essential to keeping healthy muscles, hair, skin. Drink water!!!"

• Mik...
• Taken for 1 to 6 months
• January 15, 2024

"I’m a 6’4", 275-pound male, 62 years old - no diabetes or health issues, on no other meds. Obtained prescription via Dr. and took the first 2.5 mg injection on Dec. 24. Lost 10 pounds with the first 3 shots, then Dr. said I could go to 5 mg (saved the last 2.5 mg pen for future use) because weight loss had stopped. After starting 5 mg, lost 2 pounds in 2 days - so combined weight loss using 2.5/5 mg is now at 12 pounds in six weeks! No significant or terrible side effects except some constipation, intermittent fatigue, and minor chills at times (not a lot - could just be the cold weather). I've yo-yoed up and down with weight for years. Because of my size, I can eat a lot of food - but this drug has significantly reduced my appetite, and I have more energy overall. I can’t wait to see the results in a few more months. Zepbound has so far been perfect for me. I don’t mind the $550 price (with the Lilly savings card - has been hard to get CVS to make it work, but that’s another story/nightmare)."

• Anonymous
• Taken for less than 1 month
• March 24, 2024

"Ten days on Zepbound. Love this medication. The energy it gives you is amazing. 1st day injection in thigh developed bruise and slight nausea and headache. But no biggie. 2nd shot belly super easy. Takes away urge to eat. No more stomach grumbling when hungry either. I have a protein shake in the morning, mid-morning protein bar, little bites throughout the morning. Small lunch and salmon or chicken for dinner. Veggies and fruit are important. No issue with bathroom. I take a fiber gummy and multivitamin daily. Treadmill and gym. After showering, I've been using lots of lotion on skin, massaging in. You'll be fine. Smart choices in foods. Yogurt gave me nausea as did tuna with mayonnaise. 6 lbs so far."

• GWP...
• Taken for 1 to 2 years
• March 2, 2025

"In 2023, I began taking Mounjaro and went from the 2.5 dosage to 10. I lost almost 40 pounds and then couldn't get it anymore! I put on 22 pounds in about 6 weeks! When Mounjaro became available again, I started again and lost that 22 pounds plus 50 more pounds for a total of 72 pounds. I have NEVER had a single side effect and have used EMMA for any constipation (but I've always had trouble with constipation anyway!). My goal was to get to 125 pounds and then gain back 5 pounds because all my life I've heard that it's a good thing to do to fill out your face. It may be just an old wives' tale, but I now weigh 127 and that's my plan. I guess I should tell my age so that older individuals who have suffered from the highs and lows of dieting and never being successful long-term will realize that we too can lose weight and keep it off. 84."

• Dee...
• Taken for 1 to 6 months
• April 6, 2025

"I started in January and have moved doses up monthly. This morning I took my 4th 7.5 mg dose. I did have a 2.5 mg pen malfunction and moved up to 5 a week early. I've been losing 1-3 pounds a week, for a total today of 28 lb loss. My goal is to lose 50. As far as side effects, they really aren't too bad for me. Daily Colace helps any constipation, which has not been much of an issue anyway. Occasional nausea is fleeting and is helped with Coke One. I know some are against drinking soda, but Coke One does not have sugar and has been my nausea cure for as long as it's been on the market. My appetite is diminished, but not gone. I've changed my eating pattern to several small, healthy mini-meals during the day instead of 3 'regular' meals. Zero cravings for junk food or much snacking at all. Part, I'm sure, is that I'm keeping those mini meals full of protein and vegetables. The only real issue that I've had is fatigue. It hits about an hour after the shot and lasts about 36 h."

• ali...
• Taken for 1 to 6 months
• April 29, 2024

"Started at the end of Jan 24. 4 weeks at 2.5mg, 8 weeks at 5mg due to lack of supply. I've had to seek alternatives due to the shortage of this drug, but it is worth it. I've lost 30 pounds in 14 weeks and moved up to 7.5mg on my last dose. The food noise is gone. The alcohol noise is gone. Other than some nausea and fatigue on shot day, side effects have been mild and easily manageable. I wish I'd have been able to start this long ago and gotten my life back. 30 pounds to go and I have no doubt I will be successful."

• Lis...
• Taken for less than 1 month
• May 19, 2025

"I just started taking Zepbound for less than a week now. I am 5 days in. I have not had any major side effects. I have felt very little nausea at times. I had a very mild tummy ache a couple of times. I felt a little dizzy the first day and then nothing after that. I felt very fatigued the third day but have been good since. I have lost 4 lbs so far. I am 5' 2" and weighed 161. I am down to 157 as of today (5th day). My goal is 130 at least. I don't feel hungry. I don't think about snacking. I forget to eat most of the time because I am not hungry. I have to remind myself to eat something. I eat very small portions and feel satisfied. I am loving this! I do recommend it to anyone wanting to lose weight."

• Amb...
• Taken for 1 to 6 months
• April 27, 2023

"I was on Mounjaro for 3 months for weight loss, starting weight 180 lbs. I increased to the next dosage every month. I had minimal side effects besides constipation and lost a total of 28 lbs. I did not wing off the medication, and everything went fine. I did blood work last week, and everything was perfect compared to the year before. My weight has been steady thanks to the healthy habits I built during the medication."

• Ano...
• Taken for 1 to 2 years
• May 24, 2025

"I have been struggling with my weight my entire life. It wasn't until I went on Zepbound that I began to lose weight and truly believed that this time I would keep it off for good. After 8 months, I have lost almost 50 lbs and feel better than I ever have about myself. I have more energy, more confidence, and am simply a much happier person. For me, I believe that Zepbound has helped me by regulating my blood sugar level and also making me feel full. While it is a major financial investment that needs to be changed, it has completely changed my outlook on life and fortunately I am able to afford it. This should be offered to everyone at an affordable rate!"

• Anonymous
• Taken for 1 to 6 months
• March 29, 2023

"I'm on month three. My doctor thinks I might be too sensitive to it and may have to stop soon. Extreme nausea, occasional vomiting, and sulfur burps followed by diarrhea, weakness, and lethargy. The pros: in three months, I've gone from 262 lbs to 239 lbs."

• Anonymous
• Taken for 1 to 6 months
• February 26, 2024

"So far, so good. Rarely get hungry and can't eat too much. Side effects: Heartburn, reflux, constipation, hair loss. I will have to weigh myself in the morning, but I am guessing I am down about 8 lbs. in 5 weeks. Just started on the 5 ml. No exercise yet. Wine and alcohol will definitely slow down the progress. Not a lot of cravings for junk. Every now and then I want something fried, but it will have you on the crapper by the next morning! Stay away from greasy food on this! And YES, the needle DOES hurt to me!"

• Fin...
• Taken for 6 months to 1 year
• April 25, 2025

"I have struggled with weight loss for the past 10 years. Healthy diet, regular exercise used to work for me but stopped working, and my weight steadily increased. I became afraid of food and barely ate 1,200 calories a day. Still, the weight wouldn’t budge. Doctors told me it was because I wasn’t 35 anymore or I was insulin resistant. I was diagnosed with fatty liver, and my frustration was at its peak. I am now 60, and at my peak, I was 216 lbs at 5'10" and pre-diabetic. I didn’t feel good and didn’t like how I looked. I was able to get Zepbound approved with my insurance, and it has been a lifesaver! I am now 160 and feel better than I’ve felt in years! I’ve had minimal side effects, and I’m just grateful that there was finally something to help me lose weight. I have saggy skin and don’t care. My knees don’t hurt, and I feel great! I’m not afraid of food and even eat treats in small portions without fear of gaining weight."

• Lil...
• Taken for less than 1 month
• March 26, 2023

"I have been on Mounjaro for just two weeks. I've lost 5 pounds without trying. While that's nice, I am posting a very early review to let other newbies know that other than some indigestion the first two days, I haven't had any side effects. I had major constipation on Ozempic. I find taking a daily stool softener, staying hydrated, taking a Metamucil tablet daily, and taking a daily prebiotic (get the refrigerated one in your pharmacy as it has live cultures. Keep it refrigerated!). I'm on 5 mg, but I am moving up to 7.5 next week. I will go to 10 mg if there is no supply of 7.5. My pharmacist said to get my order for the 7.5 mg in at least 7 days early so they can get it in on time. They don't stock it, but they get it overnight. Just FYI, after using Ozempic and Mounjaro, I weigh less than I did 10 years ago. I've gone down 4 sizes and 4 inches off my waist since Christmas! Now a petite XL rapidly headed to petite L."

• Nan...
• Taken for 1 to 6 months
• July 26, 2025

"I have had great success with Zepbound! I am down almost 40 pounds in 3 months. I started at 201 lbs. I have been lucky not to have any issues or side effects. I do work at it. I drink lots of water and walk 20 minutes twice a day."

• foo...
• Taken for 1 to 6 months
• July 22, 2024

"I've been on this medication for 6 weeks and have never felt better about my body or my day. I didn't realize I could have a day where I wasn't thinking about food from the minute I got up until I fell asleep at night. I feel free to think about other things and to not be distracted by trying to have willpower to not eat. It's a huge relief. Is this what thin people feel like? People who have never struggled with being overweight? I have always thought my weight was based on my genetics, and maybe it is-but it's also my brain that literally is addicted to food. It feels like I've been released from an addiction. I haven't noticed any side effects. I tried Ozempic before this and was very constipated and had stomach issues. I don't feel that way at all on Zepbound, my stomach is fine. I'm on 2.5, it's very easy to administer, and I feel like it really works. I hope I'm able to take it for a long time, I'm sort of afraid to go back to the brain I had before taking it."

• Amb...
• Taken for 1 to 6 months
• February 23, 2024

"I am 5'2", 41 years old, started taking the shot in November of 2023. Weighed in at 293, cried all the way home. Within a week lost 16 pounds. Here I am, almost a complete 4 months later, and down 72 pounds. Best thing I have ever done. No more snoring or waking up all hours of the night, and I have so much more energy. Yes, I have some constipation, but it is a small price to pay to feel so much better! Next month I will be on the highest dose. So, from here on out, it's up to me to keep it moving with healthy activity and diet."

• CJa...
• Taken for 1 to 6 months
• April 1, 2025

"I started 3 months ago with the 2 ml, then 5, and now 7.5. I have been nauseous every single day for those 3 months. I have been constipated almost every week. I finally am able to go. I noticed that after the injection, I vomit every time the next day. I am 5'7 and weighed 233. I am now 209. The nausea is sometimes unbearable. I feel like not taking this medicine. Everyone's body is different."

• Can...
• Taken for 1 to 6 months
• April 18, 2024

"I am in my 50s and I stayed on the 2.5 for 2 months and just began the 5 mg today. I had gastric sleeve exactly a year before covid, lucky me, huh? Working from home, no gym, already had depression, joint, and severe back issues. It all did not mix with slowing down and sitting down. I gained half of the weight I lost, and the high cholesterol returned. I started Zepbound on Feb 17, 2024, and lost 18 lbs by my first check-up on April 1. Very fast. My cholesterol dropped significantly. I do not have high blood pressure, but it was down too. All blood work is great. The only side effect is constipation that I fixed with Miralax. There are no food cravings or noise in my head. I get full very fast, although I have to remind myself to eat. I have dry mouth, I bought sugar-free popsicles to deal with that. I have been sleeping better, although I stay up late due to the energy it gives me."

• Chr...
• Taken for 1 to 2 years
• May 11, 2025

"In the past year, I’ve lost 86 pounds on Zepbound—and while that alone is incredible, the real transformation goes so much deeper. I feel alive again. I’m moving more, rediscovering joy in my body, and for the first time in years, I’m not battling daily IBS symptoms. It’s not just about the weight—it’s about finally having a quality of life I never thought possible, even when I was younger and thinner. I'm truly grateful for this life-changing medication."

• Mik...
• Taken for 1 to 6 months
• May 30, 2025

"This medication has absolutely changed my life. In almost 4 months, I am down 30+ lb (205 to 175). Now I dosed up very quickly because the drug has also helped me with addiction issues as well (I think). I haven’t changed anything else except pretty quickly ramping up my dosage to 10 mg, and my urge to drink/use is virtually non-existent. Not sure if it’s because I know I’ll throw up if I drink the way I used to drink (I’m getting nauseous now just thinking about it), or if this miracle drug is somehow filling that void that alcohol and drugs had filled for years. Now to be clear, I do smoke weed pretty consistently throughout the day, so I’m not 100% sober by any means, but I’m at a point where it’s very manageable. I actually very much look forward to taking my shot. For example, my fiancé went out of town for an entire week, and I haven’t even tried to seek out drugs or even had a drink for that matter."

• Mil...
• Taken for 6 months to 1 year
• December 1, 2024

"I started Zepbound in April 2024 at 193 lbs. It’s December 2024, I’m now 140 lbs. I have stayed at the 10 mg dose for almost 3 months now, as I am trying to tone my body since I lost 50 lbs fast. The side effects suck when I go up a dose, but my body adjusts after 4 weeks, so it’s been great. I have noticed that I wake up with hunger pains now, but my plan is to get used to them again before I start weaning off the drug. Side effects for me include headaches and fatigue. It’s not that bad after a while, the main thing is being strategic and proactive about getting your fiber, protein, and water in. I haven’t been to the gym since I started the 10 mg, and I’ve slowed down on the weight loss (which I’m okay with). I like 140, I’m just trying to tone now, so when I wean off, it won’t all come back. I’ll update you guys in a couple of months."

• Kat...
• Taken for 1 to 2 years
• June 8, 2025

"I have used this for over 1 1/2 years now. I have never increased from the initial 2.5 dose and have lost over 45 lbs! 63 yrs old and always fought my weight. I could literally fast for a couple of days, stay on my tuna, veggies, and berries the rest of the week, exercise every day and gain 2 lbs if my week was stressful at work. This turns on a couple of hormones that just were not working no matter what I tried. I have no plans to increase this dose, but will probably need to stay on this forever. It is the key and the answer I’ve been looking for. Most every post I’m reading talks about increasing the dose, and I wanted to share that you can get there without risking additional side effects. It’s a great tool, and with all the good things we do already for ourselves, this will take you all the way! I’m about 12 pounds to my goal, now normal cholesterol levels and no side effects after the first two weeks :). It makes the journey easier when you see success for your efforts :)"