Tirzepatide for Weight Loss (Obesity/Overweight) User Reviews (Page 4)

• Anonymous
• Taken for 2 to 5 years
• March 26, 2025

"This medication saved my life! In the beginning, the nausea was very noticeable but worth every bit! I never really had a problem with my weight until after my pregnancies. I gained over 90 lbs with each of my two pregnancies. Being at over 300 lbs and only 5’1” was a miserable existence. I couldn’t breathe and was exhausted all of the time, not to mention pre-diabetic and very high blood pressure. It has definitely been a journey, but I stand by that this medication saved my life. I’ve lost 125 lbs. I still have a way to go to get to my goal, but I’m so happy to be alive to see how much better life can be! By the way, my A1C is now normal, and the hypertension has also resolved! I’m very grateful!"

• Jea...
• Taken for 6 months to 1 year
• June 25, 2023

"I have never had anything like this in my life! I was always small and IBW until I went through menopause. Afterward, I gained weight regardless of what I did. Nothing I tried and no program I did helped. Once I reached a size 22 on my 5'4 frame and weighed almost 230 lb, I decided to do something else. By this time, I had also become 'pre-diabetic' and was insulin resistant. I have been on Mounjaro for 7 months and am now a size 8, down 65 pounds. My blood sugars are perfect, and I feel like my old self again! The journey has been effortless, and I enjoy the foods I like, but my body metabolizes it better. I have now switched to Wegovy since insurance only covers Mounjaro if you are diabetic. I would stay on it forever, but cannot continue to pay almost $1,100.00/month for it."

• Dia...
• Taken for 6 months to 1 year
• November 8, 2024

"When I started out on the lowest dosage, everything went great. I have lost 40 pounds and have been pleased. I requested from my doctor to up my dosage to 5 mg. Now I have an allergic reaction, mostly on my face. Red, splotchy, hot marks all over my face. Have there been any other patients that have experienced the same reaction?"

• Kay...
• Taken for 1 to 6 months
• January 10, 2025

"I started taking Mounjaro 2.5 mg on September 6th, weighing in at 128 kilos. I'm now on my 7th shot of 10 mg (as I stayed on 10 mg for another month over Christmas) and I weigh 106 kilos in January. This is without changing my lifestyle of exercise or food. I eat smaller portions and don't think about food half as much as I used to. It's been great up until my 6th shot of 10 mg. I would experience mild side effects of nausea, vomiting, diarrhea, sulfur burps. These tended to be spread across the board as well though, never all at the same time, and it was manageable. However, my 6th dose I felt instantly! I was nauseous for 3 days straight, vomiting, diarrhea, sulfur burps, tired, the list is endless. I was so worn out by the nausea, I couldn't sleep, eat, or drink. I took myself to the walk-in center at the hospital where they referred me straight to A&E for having a resting heart rate of 128 bpm. I was put on an IV drip, bloods taken. I felt awful and still do! Going to go back to 7.5 mg."

• Lis...
• Taken for less than 1 month
• May 19, 2025

"I just started taking Zepbound for less than a week now. I am 5 days in. I have not had any major side effects. I have felt very little nausea at times. I had a very mild tummy ache a couple of times. I felt a little dizzy the first day and then nothing after that. I felt very fatigued the third day but have been good since. I have lost 4 lbs so far. I am 5' 2" and weighed 161. I am down to 157 as of today (5th day). My goal is 130 at least. I don't feel hungry. I don't think about snacking. I forget to eat most of the time because I am not hungry. I have to remind myself to eat something. I eat very small portions and feel satisfied. I am loving this! I do recommend it to anyone wanting to lose weight."

• Anonymous
• Taken for less than 1 month
• March 24, 2024

"Ten days on Zepbound. Love this medication. The energy it gives you is amazing. 1st day injection in thigh developed bruise and slight nausea and headache. But no biggie. 2nd shot belly super easy. Takes away urge to eat. No more stomach grumbling when hungry either. I have a protein shake in the morning, mid-morning protein bar, little bites throughout the morning. Small lunch and salmon or chicken for dinner. Veggies and fruit are important. No issue with bathroom. I take a fiber gummy and multivitamin daily. Treadmill and gym. After showering, I've been using lots of lotion on skin, massaging in. You'll be fine. Smart choices in foods. Yogurt gave me nausea as did tuna with mayonnaise. 6 lbs so far."

• mje...
• Taken for 1 to 6 months
• May 9, 2024

"I originally started the Zepbound shot at the end of this past January. I weighed a total of 202 lbs when I started it. That would be about 3-4 months ago. I was very self-conscious, I didn't want to take any pictures of myself, I felt disgusted by myself, I always brought myself down, etc. But now, now I weigh 154 lbs. I'm at the 10 mg of the Zepbound. I started off as the lowest and I'm still not at the highest, to be honest. I lost about 50 pounds in the last 4 months! I researched it and it'll take 16 months to lose about 50 pounds for a normal person who doesn't take anything. And I did it in 4 months with that shot! I never thought I would get to this weight, to be honest. In the beginning, I was going to the YMCA to work out every week to put in the extra work, etc. At first, I started losing like a pound a day, not even kidding, sometimes 2 lbs a day. Then it went to a pound every couple days, and it would vary."

• Mik...
• Taken for 1 to 6 months
• January 15, 2024

"I’m a 6’4", 275-pound male, 62 years old - no diabetes or health issues, on no other meds. Obtained prescription via Dr. and took the first 2.5 mg injection on Dec. 24. Lost 10 pounds with the first 3 shots, then Dr. said I could go to 5 mg (saved the last 2.5 mg pen for future use) because weight loss had stopped. After starting 5 mg, lost 2 pounds in 2 days - so combined weight loss using 2.5/5 mg is now at 12 pounds in six weeks! No significant or terrible side effects except some constipation, intermittent fatigue, and minor chills at times (not a lot - could just be the cold weather). I've yo-yoed up and down with weight for years. Because of my size, I can eat a lot of food - but this drug has significantly reduced my appetite, and I have more energy overall. I can’t wait to see the results in a few more months. Zepbound has so far been perfect for me. I don’t mind the $550 price (with the Lilly savings card - has been hard to get CVS to make it work, but that’s another story/nightmare)."

• bae...
• Taken for 1 to 6 months
• March 18, 2024

"Absolutely life-changing. For the first time in my life, I'm satisfied by reasonable portions. I'm not always thinking about the next thing that I'll be eating. I'm able to feel and respond to my actual hunger cues without my scarcity brain taking over. Even if I wasn't losing weight, the relief of food obsession and binge eating disorder would be worth it. Four weeks in, down 13 lbs and very satisfied. Only side effect has been feeling cold and some mild constipation."

• Sus...
• Taken for 1 to 6 months
• June 24, 2024

"I’ve used Zepbound for almost 5 months & have lost 15 lbs. I experienced diarrhea at the beginning but much less now. What I didn’t expect was that my bladder issues like leaking, etc. would stop. It has been amazing! I went from needing valve & bladder surgeries to complete stoppage. I hope this info will help other women with their urology issues. Even if I never lost another pound, if another Zepbound side effect helps my bladder, I’m in!!"

• ali...
• Taken for 1 to 6 months
• April 29, 2024

"Started at the end of Jan 24. 4 weeks at 2.5mg, 8 weeks at 5mg due to lack of supply. I've had to seek alternatives due to the shortage of this drug, but it is worth it. I've lost 30 pounds in 14 weeks and moved up to 7.5mg on my last dose. The food noise is gone. The alcohol noise is gone. Other than some nausea and fatigue on shot day, side effects have been mild and easily manageable. I wish I'd have been able to start this long ago and gotten my life back. 30 pounds to go and I have no doubt I will be successful."

• Dee...
• Taken for 1 to 6 months
• April 6, 2025

"I started in January and have moved doses up monthly. This morning I took my 4th 7.5 mg dose. I did have a 2.5 mg pen malfunction and moved up to 5 a week early. I've been losing 1-3 pounds a week, for a total today of 28 lb loss. My goal is to lose 50. As far as side effects, they really aren't too bad for me. Daily Colace helps any constipation, which has not been much of an issue anyway. Occasional nausea is fleeting and is helped with Coke One. I know some are against drinking soda, but Coke One does not have sugar and has been my nausea cure for as long as it's been on the market. My appetite is diminished, but not gone. I've changed my eating pattern to several small, healthy mini-meals during the day instead of 3 'regular' meals. Zero cravings for junk food or much snacking at all. Part, I'm sure, is that I'm keeping those mini meals full of protein and vegetables. The only real issue that I've had is fatigue. It hits about an hour after the shot and lasts about 36 h."

• Amb...
• Taken for 1 to 6 months
• April 27, 2023

"I was on Mounjaro for 3 months for weight loss, starting weight 180 lbs. I increased to the next dosage every month. I had minimal side effects besides constipation and lost a total of 28 lbs. I did not wing off the medication, and everything went fine. I did blood work last week, and everything was perfect compared to the year before. My weight has been steady thanks to the healthy habits I built during the medication."

• Kat...
• Taken for 1 to 2 years
• June 8, 2025

"I have used this for over 1 1/2 years now. I have never increased from the initial 2.5 dose and have lost over 45 lbs! 63 yrs old and always fought my weight. I could literally fast for a couple of days, stay on my tuna, veggies, and berries the rest of the week, exercise every day and gain 2 lbs if my week was stressful at work. This turns on a couple of hormones that just were not working no matter what I tried. I have no plans to increase this dose, but will probably need to stay on this forever. It is the key and the answer I’ve been looking for. Most every post I’m reading talks about increasing the dose, and I wanted to share that you can get there without risking additional side effects. It’s a great tool, and with all the good things we do already for ourselves, this will take you all the way! I’m about 12 pounds to my goal, now normal cholesterol levels and no side effects after the first two weeks :). It makes the journey easier when you see success for your efforts :)"

• Anonymous
• Taken for 1 to 6 months
• March 29, 2023

"I'm on month three. My doctor thinks I might be too sensitive to it and may have to stop soon. Extreme nausea, occasional vomiting, and sulfur burps followed by diarrhea, weakness, and lethargy. The pros: in three months, I've gone from 262 lbs to 239 lbs."

• Chr...
• Taken for 1 to 2 years
• May 11, 2025

"In the past year, I’ve lost 86 pounds on Zepbound—and while that alone is incredible, the real transformation goes so much deeper. I feel alive again. I’m moving more, rediscovering joy in my body, and for the first time in years, I’m not battling daily IBS symptoms. It’s not just about the weight—it’s about finally having a quality of life I never thought possible, even when I was younger and thinner. I'm truly grateful for this life-changing medication."

• CJa...
• Taken for 1 to 6 months
• April 1, 2025

"I started 3 months ago with the 2 ml, then 5, and now 7.5. I have been nauseous every single day for those 3 months. I have been constipated almost every week. I finally am able to go. I noticed that after the injection, I vomit every time the next day. I am 5'7 and weighed 233. I am now 209. The nausea is sometimes unbearable. I feel like not taking this medicine. Everyone's body is different."

• Lil...
• Taken for less than 1 month
• March 26, 2023

"I have been on Mounjaro for just two weeks. I've lost 5 pounds without trying. While that's nice, I am posting a very early review to let other newbies know that other than some indigestion the first two days, I haven't had any side effects. I had major constipation on Ozempic. I find taking a daily stool softener, staying hydrated, taking a Metamucil tablet daily, and taking a daily prebiotic (get the refrigerated one in your pharmacy as it has live cultures. Keep it refrigerated!). I'm on 5 mg, but I am moving up to 7.5 next week. I will go to 10 mg if there is no supply of 7.5. My pharmacist said to get my order for the 7.5 mg in at least 7 days early so they can get it in on time. They don't stock it, but they get it overnight. Just FYI, after using Ozempic and Mounjaro, I weigh less than I did 10 years ago. I've gone down 4 sizes and 4 inches off my waist since Christmas! Now a petite XL rapidly headed to petite L."

• Anonymous
• Taken for 1 to 6 months
• February 26, 2024

"So far, so good. Rarely get hungry and can't eat too much. Side effects: Heartburn, reflux, constipation, hair loss. I will have to weigh myself in the morning, but I am guessing I am down about 8 lbs. in 5 weeks. Just started on the 5 ml. No exercise yet. Wine and alcohol will definitely slow down the progress. Not a lot of cravings for junk. Every now and then I want something fried, but it will have you on the crapper by the next morning! Stay away from greasy food on this! And YES, the needle DOES hurt to me!"

• Amb...
• Taken for 1 to 6 months
• February 23, 2024

"I am 5'2", 41 years old, started taking the shot in November of 2023. Weighed in at 293, cried all the way home. Within a week lost 16 pounds. Here I am, almost a complete 4 months later, and down 72 pounds. Best thing I have ever done. No more snoring or waking up all hours of the night, and I have so much more energy. Yes, I have some constipation, but it is a small price to pay to feel so much better! Next month I will be on the highest dose. So, from here on out, it's up to me to keep it moving with healthy activity and diet."

• foo...
• Taken for 1 to 6 months
• July 22, 2024

"I've been on this medication for 6 weeks and have never felt better about my body or my day. I didn't realize I could have a day where I wasn't thinking about food from the minute I got up until I fell asleep at night. I feel free to think about other things and to not be distracted by trying to have willpower to not eat. It's a huge relief. Is this what thin people feel like? People who have never struggled with being overweight? I have always thought my weight was based on my genetics, and maybe it is-but it's also my brain that literally is addicted to food. It feels like I've been released from an addiction. I haven't noticed any side effects. I tried Ozempic before this and was very constipated and had stomach issues. I don't feel that way at all on Zepbound, my stomach is fine. I'm on 2.5, it's very easy to administer, and I feel like it really works. I hope I'm able to take it for a long time, I'm sort of afraid to go back to the brain I had before taking it."

• Lin...
• Taken for 1 to 6 months
• December 5, 2024

"I started taking Zepbound on the first of September, am 5'8, was weighing 190. I stopped taking Zepbound on November 18th, had no serious side effects, I was just feeling moody. Stopped at my goal of 175.9 and still losing on my own. It's December 5, and I weigh 172.9. Zepbound has taught me to eat a balanced, healthy meal without all the cravings, portion size, and exercise. Down 16 pounds."

• Bla...
• Taken for 1 to 6 months
• April 2, 2025

"I have been struggling with my weight since I was 16. I quit smoking, had two children, entered menopause, and my weight became uncontrollable (my blood tests have always been perfect). I found the strength to start dieting a couple of times a year but hit rock bottom in March, 48 years old, 107 kgs. Depressed and unable to start -again- the keto diet (it works very well for me), I asked for help and was put on antidepressants and Mounjaro. A real game changer. I started the diet with no willpower, no bad feelings, no cravings, no need for self-control, just naturally. I got into ketosis easily and quickly. As a side effect, I have slight nausea a couple of days after the injection. No big deal, as it helps with the diet. No more food noise, I am able to think and prepare my meals without rushing, and so far, I have lost 6 kg in 14 days. I plan to continue for as long as I can and then stop and get my weight under control. We'll see."

• Can...
• Taken for 1 to 6 months
• April 18, 2024

"I am in my 50s and I stayed on the 2.5 for 2 months and just began the 5 mg today. I had gastric sleeve exactly a year before covid, lucky me, huh? Working from home, no gym, already had depression, joint, and severe back issues. It all did not mix with slowing down and sitting down. I gained half of the weight I lost, and the high cholesterol returned. I started Zepbound on Feb 17, 2024, and lost 18 lbs by my first check-up on April 1. Very fast. My cholesterol dropped significantly. I do not have high blood pressure, but it was down too. All blood work is great. The only side effect is constipation that I fixed with Miralax. There are no food cravings or noise in my head. I get full very fast, although I have to remind myself to eat. I have dry mouth, I bought sugar-free popsicles to deal with that. I have been sleeping better, although I stay up late due to the energy it gives me."

• R S...
• Taken for 6 months to 1 year
• December 31, 2024

"I've been on Zepbound for 6 months, and it has worked great for me! 40 lbs. down!!! I only feel yucky the day after the injection, but other than that, no other concerns. I just received a letter from my insurance company (Keystone East) stating that beginning 1/1/2025, IBX in whole is no longer covering weight loss drugs. WOW!!!! :( People like myself have been waiting most of their lives for a drug like this, and here we go with corporate America. Even though I'm 40 lbs. down, I still need to lose an additional 40 lbs. just to be considered overweight and not obese in the medical world. My joints no longer hurt, and I can work out without the aches and pains. My overall health has improved so much, and I am greatly disappointed and upset with this decision from IBX. I wish everyone much luck if this will be happening to you too after the new year."