Prednisolone ophthalmic and Depression: What Users Say

• Jan...
• Taken for 1 to 6 months
• December 28, 2019

For Postoperative Ocular Inflammation "On prednisolone eye drops 4X a day both eyes for severe viral conjunctivitis following corneal transplant. They work in terms of clearing up inflammation BUT the side effects are 1. Severe and 2. NOT reported in literature. I have very bad stomach upset, pain, bloating, severe diarrhea. Also Insomnia, fatigue, and mental changes. This is DEFINITELY from the drops as this has happened before. I’m so sick and tired of being told these drops aren’t absorbed systemically in enough quantity to cause problems. Rubbish! They’re AWFUL. I hate Prednisone and wish doctors would come up with another way to treat these issues. This drug is effective but the side effects are debilitating."

• Anonymous
• Taken for less than 1 month
• March 29, 2021

For Postoperative Ocular Inflammation "Started these drops 5 weeks ago, before and after cataract surgery. I have never been so drowsy during the day, yet wake up numerous times during the night. Heart palpitations, dizziness, confusion, blurred vision, and depression are becoming my new normal. I'm also taking brimonidine drops temporarily. Two more weeks of this is about all I can take."

• Kim...
• Taken for less than 1 month
• February 25, 2025

"Used this from a neuro-ophthalmologist prescribed for a chemical burn in the eye. From the start, I started feeling anxious and a weird depressed overwhelming feeling with an anxious fur feeling that persisted the entire length and afterward. I only used it in one eye, but my other eye was having burning effects from the medication as well. Even days after stopping, the opposite healthy eye was tearing up with a burning sensation while the injured eye was as well. This stuff left a crusty residue inside my sinus, which is just so beyond mind-boggling how the other effects come from this medication. I cannot say if I would recommend this because it seems so toxic for mental health. Very difficult overall situation then to have to take this drug makes a whole other situation arise. Now seeing other reviews, I see others suffered too. Oh, and irritability, moodiness, anxiousness are all at an extreme heightened level."