Trulance and Diarrhea: What Users Say (Page 4)

• Tri...
• Taken for 1 to 6 months
• September 28, 2022

For Irritable Bowel Syndrome with Constipation "I have been taking Linzess 290 mcg capsules since 2017 for IBS-C. Also taking up to 1,200 mg (Colace) per day. Sometimes would need 20 mg of Dicyclomine for abdominal cramps. I stopped taking Linzess on Sept 9, 2022; started Trulance the next day. Had two normal BMs that day. Began having incredible lower abdominal pain the next day. Constipation continued. The abdominal pain continued nonstop for days. Day 9, I had diarrhea six times in 45 minutes. Day 15, stopped taking Trulance. Day 18, I tried it again, no change in cramps. Day 19, had a fever of 100 in the evening, feeling sick. Day 20, feeling better, took two laxatives plus MiraLAX. Some residual abdominal soreness. Will not be trying Trulance again, will probably go back to Linzess."

• Hop...
• Taken for less than 1 month
• April 29, 2021

For Irritable Bowel Syndrome with Constipation "First time taking Trulance, it did nothing over 5 days, except stomach grumbling, headaches, and mild dizziness. Trying it again, and now I get watery diarrhea within a few hours of taking it, which takes up half my day. I cut back to every other day with the same results. I also have diverticulosis, which flares up terribly after all the diarrhea. Now I'm getting indigestion and some reflux, along with bloating. Not sure if this is the answer."

• Jay...
• Taken for less than 1 month
• October 26, 2021

For Chronic Idiopathic Constipation "I was constipated for about a week. Went to see my Dr, and he gave me a sample to try. I had severe diarrhea for 4 days with no resolve. Got off the meds and increased fiber and water intake. Success! 2 movements this morning so far."

• Anonymous
• Taken for less than 1 month
• September 20, 2021

For Chronic Idiopathic Constipation "I have been taking Trulance for 2 weeks, the jury is still out! I do feel better, no bloating or GI problems, and the gas is getting better, but the diarrhea is explosive. Trulance claims you don't have to plan your day around taking it, well, that's a total lie! Because a few hours after I take it, my stomach starts to bubble so bad it's like someone blowing into my stomach through a straw. Then the diarrhea starts, and I go a couple of times, so I have to plan what time of day I can take it, so it's day by day. But I do feel better, I feel emptied out. I don't look as bloated as before, today is the first day I have had solid stool since starting it, so we will see. It does say that you can have diarrhea for the first 4 weeks. I go back to my GI doctor in a couple of weeks, so I will see what he says then, but I will keep taking it till then."

• Pop...
• Taken for less than 1 month
• August 25, 2021

For Chronic Idiopathic Constipation "After all the things over the years taken for constipation, I was excited for this pill. Diarrhea would be better than blown up forever. WRONG! Took one pill yesterday. Wham, bathroom for projectile diarrhea! After 5 times, I'm worn out and changing my clothes and cleaning the toilet over and over. Stomach sounded like a T-Rex inside! Bad headache ever since also. And after all the pre-authorization!! Wish I had read these reviews first!! I can't give this time to level out. Can't take the chance not to meet this awful headache. Welcome back senna and Miralax, etc."

• ano...
• Taken for less than 1 month
• September 14, 2021

For Irritable Bowel Syndrome with Constipation "I got told to take a saline laxative to clean myself out, then start the Trulance (3 mg). The GI told me she hasn’t heard of anyone getting diarrhea from it, so it shouldn’t happen. I’ve read all the reviews about people experiencing this and told to stop taking it if it happens to me. This is my first day starting it, and not even 45 minutes after taking it, I was having explosive diarrhea for about an hour. Out of the bathroom for 5 minutes and now back again for another hour of having explosions. I don’t know when it’s gonna stop, but I know I’m not taking it again. I give it a 4/10 because I guess I did still have some left in my system from the laxative, but it’s not a good time at all. Make sure you talk to your doctors about the medication and find out more before taking it instead of not being told anything about it when it gets prescribed."

• Dcu...
• Taken for less than 1 month
• May 23, 2017

For Chronic Idiopathic Constipation "The first 3 days, I experienced diarrhea within 2 hours of taking Trulance 3 mg tablet. I continued taking it, and I am now 15 days in and have to take an enema for constipation. Seems that Trulance is no longer effective in my system. I am very disappointed!"

• Bin...
• Taken for less than 1 month
• April 16, 2025

For Irritable Bowel Syndrome with Constipation "I had an IBS diagnosis that caught me completely off guard. My symptoms started in mid-January 2025, and I thought I had a UTI. Labs that my PCP took proved negative. So next was the urologist who ordered labs and a CT scan. All negative. Next, the gastro doc. Voila, IBS. Tried Linzess and spent days in and out of the bathroom with diarrhea. Not fun. Am now on Trulance, only 3 days at the time of this review. I've had small bouts of diarrhea, but manageable. It seems to be a less invasive medication, and I am holding out for a much improved gastro experience. I am also visiting with my dietitian soon to determine what I should be eating. I'm also stage 3 kidney disease, so a diet that satisfies both could be tricky!"

• Mrs...
• Taken for 1 to 6 months
• January 18, 2025

For Irritable Bowel Syndrome with Constipation "I have had severe chronic constipation since childhood. OTC medications, herbal supplements, teas, dietary changes, etc. never provided a consistent solution. Pros: Trulance has changed my bowel habits entirely. From 1 bowel movement bi-weekly to 3-4 a week. It has significantly reduced symptoms of bloating, nausea, vomiting. Cons: The most foul, putrid-smelling flatulence and diarrhea upon starting the medication. Urgency. Make sure you take it at night when you are in the comfort of a nearby bathroom with baby wipes."

• Reb...
• September 26, 2017

For Chronic Idiopathic Constipation "This is a life changer for me, I've had issues since I was a teen and I'm in my early 40s now. I honestly thought that was normal."

• Lar...
• Taken for less than 1 month
• February 6, 2020

For Irritable Bowel Syndrome with Constipation "Worked great! Had much less diarrhea than Linzess."

• gra...
• Taken for less than 1 month
• June 18, 2017

For Chronic Idiopathic Constipation "Awesome! Tried one other drug before and just gave me terrible diarrhea. Works much better. Will renew. My doctor was very helpful."

• Lia...
• Taken for 1 to 6 months
• October 26, 2017

For Chronic Idiopathic Constipation "Works great! I can take it whenever I want during the day, no diarrhea and no abdominal pain."

• Pau...
• July 31, 2017

For Chronic Idiopathic Constipation "I was using Linzess for the past 1 1/2 years, but had diarrhea pretty constantly. Switched to Trulance and significantly better with diarrhea, and my movements are a tad better also."

• Cha...
• Taken for 1 to 6 months
• June 5, 2018

For Irritable Bowel Syndrome with Constipation "Trulance works as intended, it is easy to take. It gave me a bit of diarrhea at first, but now it works perfectly."

• Anonymous
• Taken for less than 1 month
• February 10, 2018

For Chronic Idiopathic Constipation "After taking this pill, 1 hour felt cramping and gas. Started with normal bowels, then explosive diarrhea."

• Anonymous
• Taken for less than 1 month
• June 29, 2018

For Chronic Idiopathic Constipation "Causes severe diarrhea. Do not recommend."

• Dom...
• Taken for less than 1 month
• July 17, 2018

For Irritable Bowel Syndrome with Constipation "First and second day bloating. The third day, I had very bad diarrhea for 10 hours. Don't think I will continue taking this drug."

• car...
• August 28, 2017

For Chronic Idiopathic Constipation "Severe diarrhea and fatigue."

• SUB...
• Taken for less than 1 month
• June 14, 2017

For Chronic Idiopathic Constipation "I had diarrhea and stomach pain for the first week, and then nothing, but weight gain of 6 pounds by the end of the month. Going back to senna, as this is not for me."

• Anonymous
• Taken for less than 1 month
• December 14, 2017

For Chronic Idiopathic Constipation "Took 1 pill, 2 hours later very bad diarrhea...don't think I will continue taking this. I just want something to make me go normally and no bloating :("

• Cta...
• Taken for less than 1 month
• January 6, 2021

For Chronic Idiopathic Constipation "Only took half a pill. First time to take it. 8 hours later, still having diarrhea. Will never take again!"

• Mar...
• May 27, 2017

For Chronic Idiopathic Constipation "I decided to give this drug a shot, but it just doesn't work and gave me very bad diarrhea. I am very disappointed."