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User Reviews for Trulance to treat Irritable Bowel Syndrome

Trulance has an average rating of 6.6 out of 10 from a total of 47 ratings for the treatment of Irritable Bowel Syndrome. 53% of those users who reviewed Trulance reported a positive effect, while 28% reported a negative effect.

Trulance Rating Summary

6.6/10 average rating

47 ratings from 44 user reviews.

Compare all 76 medications used in the treatment of Irritable Bowel Syndrome.

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Reviews for Trulance

Hope · Taken for less than 1 month April 29, 2021

“First time taking Trulance it did nothing over 5 days except stomach grumbling, headaches and mild dizziness. Trying it again and now I get watery diarrhea within a few hours of taking it which takes up half my day. I cut back to every other day with same results. I also have diverticulosis which flares up terribly after all the diarrhea. Now I'm getting indigestion and some reflux along with bloating. Not sure if this is the answer.”

7 / 10
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Kathy · Taken for less than 1 month April 16, 2021

“Thank God for this medication , I was suffering so bad with constipation, it was so bad it made living hard work, what good is living if your bowels don't move. Trulance saved my life. I feel wonderful.”

10 / 10
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Annie · Taken for less than 1 month March 26, 2021

“So an update from my review yesterday. I took half a pill yesterday having just been given samples. It took like 6 hours to kick in. I had to do an enema to get the ball rolling but as soon as I did I passed everything I've eaten in 30 years! Yippee. Relief! I took a half today and worked in 2 hours. Zero pain mild bloat and mild cramping and full relief. I had three trips to the toilet and pretty much nothing left now. Half a pill is worth the try for anyone who can't handle a whole pill. Seem to clear out within an hour or two then can go about my life. Good luck guys!”

8 / 10
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Frequently asked questions

JLB · Taken for 1 to 6 months May 16, 2020

“I have been on Linzess for several years with occasional diarrhea, but not painful. It has worked very well for me. My insurance company recently required I try Trulance for 3 months. I am just starting on my 3rd month and I can count on one hand the number of days I have not had explosive diarrhea. Within about 2 hours of taking it my guts start grumbling & rolling, followed by cramping, then usually 2 or 3 trips to the bathroom within a couple hours time period. I have had hemorrhoids swell up and bleeding at one point it was so bad. My next biggest complaint would have to be the packaging! It’s ridiculous, almost impossible to pull the insert out without ripping it open.”

5 / 10
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Shep · Taken for 1 to 6 months August 12, 2020

“I am on my fourth month. When I first started taking this Trulance medication, I was scared. Like a lot of others, the rumbles start happening soon within an hour. For the next 6 hours, I have to remain vigilant about the bathroom. For me it ranges from explosive to streaming liquid. This cycle can get exhausting so I will admit that I won't take it every day. There are few times where the medication won't seem to work. There might be some grumblings, but no passing. I attribute this to a few things: 1. Lack of water. You have to drink a lot of water throughout the day with this medication. 2. Bad diet. A lot of us have to accept the fact that we shouldn't be eating greasy foods, large meals, or drinking alcohol anymore. 3. I personally need to take this during the day. If I lay down after taking it, that only challenges my bowels even more. I will keep taking Trulance while working on my diet and hydration.”

8 / 10
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SAL · Taken for less than 1 month September 3, 2020

“I have been diagnosed and struggling with IBS for over 25 yrs and recently started taking Linzess for about a year then it no longer worked so I tried samples of Amitzia which worked but my insurance denied the Rx, I started seeing a GI doc who prescribed Trulance and for the first 7 days I had no result, I went to the ER complaining of 3 weeks of constipation, got a x-ray and CT scan which showed no stool in my intestine. That was $125 copay wasted. Three days later I started having diarrhea constantly, bottom was sore and I was exhausted from sitting on the toilet and not able to go to bed. Trulance works better for me when I take it after I eat, an hour later I have good bowel movements and regularly since taking the medication. I pray it continues to work.”

10 / 10
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Wendy August 17, 2020

“I’ve had IBS-C for about 5 years now. They started me on Linzess and I have taken all the types of doses it comes in and even though it worked it made me still spend way more time in the bathroom due to constant diarrhea, almost so bad I couldn’t hold it in. After years of running to the bathroom all day everyday or sitting in bed in pain from not taking it they put me on trulance. At first it took a while to come around as I thought it was worse than Linzess or didn’t work, but after giving it more time I realized I mostly only have one or two good movements a day that don’t cause pain and I can even skip it for a day and mostly still have a good movement on the skipped day. My only complaint is that sometimes it seems to move a bit too fast for my track and I have pale diarrhea which after all my testing the drs say is that side effect. I would really recommend but just advise to give it time because it definitely didn’t start well for me but has now become my life saver.”

9 / 10
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Aviator · Taken for 1 to 6 months February 9, 2019

“Started this last year and the first 2 weeks were rough. I'd get gurgling sensations in my stomach each time I took it, along with bloating, gas, and diarrhea for a couple hours. BUT my GI warned me that it could happen, and to give my body time to adjust. After 2 weeks the gurgling stopped. Diarrhea turned into 1-2 times a day, and since then, I am having regular bowel movements. No side effects. The only exception is when I eat certain types of food (normally greasy or high in fat). I notice that a have 1 or 2 loose bowel movements the following day. Having IBS with constipation, this was the only medicine that was able to keep me regular. I used to go 5-6 days without going. I was in pain, backed up, bloated and had no life because I always felt terrible. Not anymore. I know some people can't handle the diarrhea, but I promise you, it is normal at first, but you have to give it a chance, beyond just a couple days.”

10 / 10
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gingergal00 January 13, 2021

“This medicine is supposed to be taken every day. With the approval from my doctor I take it twice a week. This medicine typically takes anywhere from 30 min to 2 hours to kick in. Get up at 4AM and take it with a full glass of water. I work at 9AM from home so my bowel movements are typically done then. Be prepared to be at home for 4-6 hours. Occasionally do I have abdominal pain from the medicine. Starts with some solid poo and then changes to diarrhea. I typically go diarrhea around 5-7 times that morning. My side effects on good days are just diarrhea. HOWEVER, I have a bad day at least every other week where the medicine makes me so sick and weak. It makes my chest feel really weak and my body. I typically stay somewhat dizzy throughout the day and can get headaches. Regardless of these episodes for me the medicine is still worth it, to not be living in constant horrific pain from bowel movements and constipation.”

9 / 10
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Penelope · Taken for 1 to 6 months January 12, 2020

“I’ve been taking this medicine for a month now (3mg). The first time I took it, I had a whale call from my insides and had explosive diarrhea for about an hour. I knew that it was a side effect and that it could go away with time. No. Three weeks later and still the same thing. I take the pill and within 20-60 minutes, I get the squirts normally around 10 times. I do feel clear and less bloated, but I am scared to take it on days I have a meeting, will be traveling, will be going outside, etc. Basically- I don’t want to squirt in my pants! This stuff I have no control when the urge hits. And the pain that comes with squirting pure stomach acid is so much to handle. It’s not always acid, but it is at least 1 out of 5 times. I have acid reflux but I would have that if I took the meds or not. Lord help us”

8 / 10
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LB · Taken for less than 1 month July 29, 2020

“I've been on Linzess for years now for my IBS-C. My insurance decided to deny me and MAKE me try Trulance. I'm on day 2 and I've never felt so sick from a medication in my life. The nausea, bloating and nasty belly pains are so bad today. It's to the point that I'm running to the bathroom and not knowing which end its coming out of. Dealing with this while working is not easy. Had explosive diarrhea and now I have the shakes and feel so weak. Btw nausea is at an all time high as well. My stool is now pale in color. I'm all set with this drug!! No thank you!”

2 / 10
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Luvey · Taken for 6 months to 1 year January 3, 2021

“I have had horrible, chronic constipation for 3 decades. Having a bowel movement was like having a baby with the result ended up with pelvic prolapse. Finally started Ametiza, took it for 5 years with still hard stools. Finally switched to Trulance in February. Have tried at various times but diarrhea is always the result. Covid has kept me home and so I can handle it. But we normally travel a lot and I CANNOT IMAGINE going out with uncontrollable diarrhea. I feel frustrated. Miralax gives me putrid smelling gas. Linzess is not an option. Wish Trulance comes in lower dose. May be that will reduce the diarrhea?”

7 / 10
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BlueWaterGirl1988 · Taken for less than 1 month July 25, 2020

“Doctor gave me samples of this after Linzess made me constantly bloated (I looked pregnant) and gave me nothing but diarrhea. Trulance does the same to me when it comes to diarrhea and it seems a bit worse at times, like having to stay on the toilet for 2 hours. Sometimes it doesn't work as great and I feel horribly bloated on my left side until I wake up the next day. One good thing is that I'm not constantly bloated anymore but the diarrhea is a let down because I need to be able to leave the house. It's been 3 weeks on this medication and I'm not sure if I'm really liking it much, I'm not sure what the doctor will suggest next.”

4 / 10
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IBD Dx · Taken for 1 to 6 months January 23, 2020

“I was diagnosed with IBD a year ago after a year of tests and changing to a new GI doc, I was placed on a low dose of Linzess 12/2018 but because I was in the bathroom for many hours, I only took it during the week or if I was home (I work at home so that helps). I would not take it on weekends or any day I was off or on vacation. I would take it at 5:15 am and knew by 7:15 am the medication would take affect. By the afternoon, I was able to go out. My doc changed me to Trulance this December hoping that this medication would have a different effect. It does not. I do the same routine with this medication. During the times that I did not take Linzess or do not take Trulance I take a 6-oz glass of prune juice and 2-3 medjool dates from Costco at night. Sometimes I warm the juice. This remedy usually helps me. I am hoping at some point to get off any medication.”

9 / 10
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Rose · Taken for less than 1 month January 28, 2019

“I have been suffering 45 years with severe IBS. I have taken every single prescription and over the counter medicine for it. Everything works for a couple of days and then I’m back to normal. I am now taking Trulance and it is like a miracle drug. With an hour to two after I take it I feel gurgling in my stomach and then I go diarrhea about 4 times. I feel amazing. No bloated ness anymore. I feel so empty and it feels great. Highly recommend this pill.”

10 / 10
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BR · Taken for less than 1 month December 24, 2019

“I hadn't gone in 5 days when my insurance finally approved Trulance. My doctor had prescribed Linzess but the insurance company denied it. They wanted me to try Trulance first .(My longest was 8 days without a BM and I ended up in the ER for bleeding after straining.) I took the pill shortly after I picked it up from the pharmacy. Within 1 hour I had explosive diarrhea....yes I felt relief but not better. The side affects are too much...headaches (and yes I drink tons of water), lack of energy (I am usually bouncing off the walls), and the fast weight gain (4 lbs in two days)! I also experienced no bowel movement when I took the second, third and fourth dose. Horribly indigestion and just a flu like feeling. I hope one day I can find relief but for now I think I will go back to laxatives and stool softeners.”

2 / 10
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Fred · Taken for less than 1 month November 27, 2020

“Trulance works great with me and I love the medication. A real lifesaver. Amtiza did not work and linzess gave me constant heart flutters. I typically have a bowel movement within 1-3 hours. Sometimes very wet stools, sometimes not. The first day I took the medication I had extreme pain with bowel movements over night. I only had a fraction of the pain the next day I took it, and now I am painless.”

10 / 10
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Ms. Poopy Pants June 5, 2019

“So I’ve been taking Trulance for almost a year now. The lowest dose (3 mg) I believe. I went to a GI dr because I was having stomach pain. I had an endoscopy and colonoscopy done and everything looked good minus some gastritis and a really loopy colon. I ended up having robotic pyeloplasty due to an UPJ (Ureteropelvic junction obstruction). She put me on Trulance to help me have good BM’s. I take one pill 30 mins before breakfast. And then I have to stay by a toilet for at least an hour. Explosive, runny, and loud Hershey squirts. So I guess it does make me go...even though it was actually my kidney that was causing the stomach pain. Dr said my colon is loopy and I’ll have problems if I don’t take something. My real complaint is the weight gain. I would say probably 10 to 15 lbs in almost a year. Thinking about switching. Or seeing if I can get off the meds altogether. Hope this helps. God bless and good luck!!”

6 / 10
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Cake Baker · Taken for less than 1 month December 17, 2019

“I have had gall stones with all of the worst symptoms like IBS and severe pain, removal of gallbladder followed trip to the ER. Fast forward a year of IBS with constipation and gas that I have tried to treat with healthy diet and lifestyle, after bleeding started I had my first colonoscopy and they found & removed a benign polyp. Fast forward another year of avoiding dairy and upping fiber & water, still constipated with acid reflux and gas. I got to a point I couldn’t swallow food without getting choked so I went to doctor for the reflux and constipation again. I took Trulance a week, thought nothing was getting better because I had hard small BM for 6 days, day 7-the evening after my Endoscopy it hit me.I finally had a good BM...but it was followed by hours of diarrhea. I was going every 15 minutes as if I had taken the prep drink for a colonoscopy.”

5 / 10
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Nita · Taken for less than 1 month May 1, 2019

“I’ve been suffering from IBS-C since 2009. Sometimes it’s so severe that I get stressed something more serious is going on. After 3 colonoscopies, CT-scan and taking Amitiza, Linzess I was prescribed Trulance along with Dicyclomine (for discomfort/pain) and IBGuard (by my 3rd Gastro). I’ve been taking it for 3 weeks I’m finally feeling better. I can even have a few consecutive days at a time without any pain at all. I’ve also been sticking to eating FODMAP free since 2015. It never worked before while on the other meds but everything seems to be working together now. I’m so much happier and comfortable in my clothes, when I go out, and in the bathroom than I was prior to Trulance. The only discomfort I’ve had while on it is acid-reflux. However, I’m not sure if its due to Trulance or the other meds I’m taking now. Good luck to other taking it!”

8 / 10
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Cyndee · Taken for less than 1 month August 21, 2020

“Trulance is horrible..... this is not helping my IBS C at all it making it worst after years of use BC&BS PPO denied me refills for Linzess. I feel horrible. After 3 days I will stop meds. I have diverticulitis and a gastric bypass patient For 1 year. I have to get relief somehow!!!”

1 / 10
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jennyt1 · Taken for 1 to 6 months October 27, 2018

“Trulance is a life saver for me! I use to suffer a lot because of my stomach, now I take Trulance every morning, go to the toilet about an hour later and for the rest of the day I'm free from thinking about it, I don't get anxiety anymore because of this condition.”

10 / 10
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Trinity · Taken for 1 to 6 months November 18, 2018

“My doctor gave me a month trial of Trulance hoping that it would work better for me. It worked within 3 0mins of taking it. I noticed a difference when I took it without food vs with food. With food, I would be running to the bathroom about 17 times before the diarrhea stopped. My rectum would be very painful afterwards. Taking Trulance without food was better, I'd go 4 times with 1 regular stool then the rest runny/explosive diarrhea. I did have side effects. I would get dizzy spells every day that I took the pill. I also started getting blurry vision, no matter how much I blinked or rubbed my eyes. The blurriness wouldn't go away. Lastly, it made me gain weight. My diet has been the same for months except my sweets have been cut down. I go to the gym for 1 hour 3 times a week. At the end of my monthly trial, I gained almost 11lbs! I have never gained that much weight that fast. Before Trulance, I was actually losing weight. I will happily go back to Linzess.”

3 / 10
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Bethany · Taken for 1 to 6 months September 11, 2018

“Began taking for severe constipation and from the very first to almost 3 months later, I still have nightly very VERY watery stools for 5-8 hours. Cannot take this medicine and have any evening plans. I can almost guarantee that 1 1/2 hours after taking this medicine I will feel the first gurgle and will spend the rest of the night in the bathroom. It has helped with the pain in my abdomen and distension is almost gone. I feel better the next day until I take the next dose.”

4 / 10
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Anonymous · Taken for 1 to 2 years March 29, 2018

“I began Trulance about a year and a half ago, soon after it was released onto the market. For years I had taken a probiotic, and my pain was worse. I did a Miralax regiment for several months, with no luck. My doctor then put me on Linzess, which was the most miserable I’ve ever been in my life. I was prescribed Trulance and have had very few problems since. If I maintain a diet and eating schedule, I have a regular BM every morning. I rarely have pain, if I do, it is caused by gas of not taking my pill on time. Trulance has drastically improved my confidence as I reclaimed my health.”

9 / 10
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Owie · Taken for 1 to 6 months February 8, 2021

“IBS-C and Linzess did now work for me... Been using Trulance for almost 4 months now and overall it had really helped me. It works best for me either right before or right after a meal, about an hour after taking, my stomach starts the rumble and grumple and within a few hours it does give you diarrhea (some days worse than others) and with me it’s usually more than 1 trip to the bathroom... I will say it’s not super consistent for me, some days I go and other days I get the rumbling without going but I’ll take that over not being able to go for weeks at a time. Sometimes get cramps and lots of gas and dizziness but usually only when I ate bad food or haven’t eaten at all.”

8 / 10
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homer alverson · Taken for less than 1 month April 11, 2018

“I have had irritable bowel syndrome with constipation (IBS-C) for most of my life. I am a 56 year old man. I have had other problems since my early thirties which are side effects from eating and drinking anything that contains sugar. If I eat ketchup on fries, drink a soda or a glass of sweet tea, I am unable to keep my eyes open after 30 minutes and have to sleep off the symptoms. I started taking trulance last friday. I have had a bm every day since then. I no longer have side effects to sugar. I love this medicine!”

10 / 10
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Speech · Taken for less than 1 month January 6, 2020

“Tried Trulance for 3 weeks. Have history of ibs-c. Have taken miralax for 3 years each night. It worked but lots of bloating and discomfort. First week on trulance was ok but hard stools. Progressed to very hard stools, terrible bleeding internal and external hemorrhoids. Tried adding citucel upon dr suggestion. Made everything worse. Stopped taking using stool softeners but will probably go back to miralax. Maybe I’m different as I have celiac but I do not recommend I’m now backed up with terrible pain”

3 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

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