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Saxenda and Heartburn: What Users Say

Heartburn: mentioned by 63 users (4.4%)

Based on user experiences from 1,448 Saxenda reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 38.2%
constipation 12.8%
headaches 10.8%
tiredness 8.1%
vomiting 7.7%
diarrhea 7.5%
fatigue 6.8%
heartburn 4.4%
loss of appetite 4.1%
sick 4.1%

Reviews for Saxenda

Commonly mentioned side effects
  • sjs...
  • Taken for 1 to 6 months
  • June 25, 2024

For Weight Loss (Obesity/Overweight) "I didn’t think Saxenda would work for me as I mainly eat out of boredom. My start weight in March ‘24 was 83 kgs, and in 3 months, June ‘24, it is 77 kgs. I find I can’t drink much alcohol, and my meal portions are smaller. I’ve had a couple of episodes of diarrhea when I’ve overindulged, and early on, heartburn was quite prevalent, but I found Gaviscon worked immediately. I haven’t been able to do any exercise due to a bad leg, so I’m happy to have lost the 6 kgs. The injections are simple to do, the biggest downside for me is the cost, and I’m concerned about putting weight back on when I stop taking it. So, apart from the cost, I’m very happy with Saxenda."

10 / 10
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  • MDL...
  • Taken for 1 to 6 months
  • March 24, 2023

For Weight Loss (Obesity/Overweight) "Started taking Saxenda and initially saw some limited results. Side effects were minimal, I had some heartburn and constipation, but nothing else. Lost approx 7 lbs in conjunction with a 2000 kcal p/d diet. However, was unable to lose any more weight despite consistently being in a calorie deficit. Also discovered that Saxenda really didn't help very much with hunger/cravings as it was supposed to. I haven't binged while on it, but remained constantly hungry. Ultimately, a disappointing result."

3 / 10
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10 Report
  • JAG...
  • Taken for 1 to 6 months
  • March 4, 2023

For Weight Loss (Obesity/Overweight) "I’m 47 years old. After four weeks of daily injections, I have lost 14 lbs with minimal side effects. I had burping and heartburn in the first 2 weeks and fatigue lately, but well worth it. Feeling much better overall and pleased with the initial weight loss."

10 / 10
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Frequently asked questions

  • Gen...
  • Taken for 1 to 6 months
  • October 15, 2022

For Weight Loss (Obesity/Overweight) "My experience with Saxenda was mixed. There were some good things and some not so good things. My first attempt with Saxenda lasted about three weeks. My water intake increased and my sweet tooth disappeared, most food was unappealing. My appetite disappeared completely. I experienced lots of heartburn and nausea. Three weeks in, that became hyperemesis, I vomited multiple times after every meal. I woke up in the night and vomited. I passed out while at my local dog park. The good things: I lost 22 pounds. I became more physically active, and my impulse eating has decreased. I'd recommend Saxenda to others. I would recommend that prescribers offer more support and contact to people taking Saxenda."

5 / 10
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  • Suz...
  • Taken for 1 to 6 months
  • September 7, 2022

For Weight Loss (Obesity/Overweight) "I'm 58, always walk about 4 miles with my dog each day, but at 5'3" and weighing 156 lbs, my weight was slowly creeping up. This is because I love wine, cheese, bread, pasta, takeaways, and any type of salty snack. I've no 'off switch' and no portion control. My clothes were all too tight, I started to feel lethargic and was losing self-confidence as I was becoming a chubby blob. A friend recommended Saxenda to me, and it's worked brilliantly. All the above foods are repellent to my brain, I don't want them at all. I can sit next to a bowl of peanuts and casually ignore them! I'm 4 weeks into using Saxenda today and have lost 16 lbs. Only side effects have been constipation (still) and 3 weeks of heartburn (now gone). I'm still on 1.2 mgs as my appetite is suppressed. Saxenda gives me the willpower that I didn't have to stop eating rubbish."

10 / 10
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  • Nad...
  • Taken for less than 1 month
  • May 25, 2022

For Weight Loss (Obesity/Overweight) "So I’m on my second week of Saxenda on 1.2 dose. I'm gaining rather than losing weight, and the heartburn is like somebody has a flamethrower down there. How long till you actually see any weight loss?"

3 / 10
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  • ETN...
  • Taken for 1 to 6 months
  • April 6, 2022

For Weight Loss (Obesity/Overweight) "I used Saxenda for about 6 months last year. I experienced fatigue and major heartburn. I did lose my appetite at first but did not really lose weight and gave it up because of the heartburn. Also, the daily injections were hard. Sometimes it was fine, but then there would be bruising that lasted for a week or 10 days."

3 / 10
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More FAQ

  • Nic...
  • Taken for 1 to 6 months
  • November 10, 2021

For Weight Loss (Obesity/Overweight) "I am 5' 10" and started at 232 lbs. Like many people, I was put on a medication that made me gain a lot of weight - over 50 lbs! I started Saxenda a week ago, and I can't believe how quickly the weight is coming off. Today is day 8, and I am down 7 lbs (almost a pound a day). The first few days, my stomach was upset, but it went away. I also have heartburn, but Tums help. I was on 0.06 mg for 7 days, and I just started 1.2 mg. I will keep increasing every 7 days until I'm at 3 mg. I do a high-intensity workout twice a week and restrict my calorie intake to 1700 a day. I notice I am not as hungry as I used to be. I will update in a few months!"

9 / 10
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10 Report
  • Nat...
  • Taken for less than 1 month
  • October 3, 2021

For Weight Loss (Obesity/Overweight) "Almost done with my first pen. Did not curb cravings and no side effects yet (ok, maybe minimal heartburn). Thinking, should I even start the second one, or am I just injecting chemicals in my body for nothing? Disappointed."

1 / 10
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1 Report
  • Gil...
  • Taken for less than 1 month
  • October 1, 2021

For Weight Loss (Obesity/Overweight) "Started Saxenda a few weeks ago, and I have literally felt like nothing to eat since I started the pen. All my favorite things just don't interest me at all, and I couldn't even face the smallest bite. Really weird. Horrible vomiting the other night and constantly nauseated with heartburn too. Popping pills like Smarties. Hope this passes in a day or two. Can't continue like this much longer."

8 / 10
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  • Gag...
  • Taken for less than 1 month
  • June 25, 2021

For Weight Loss (Obesity/Overweight) "I started the sample pack back in April, and the only side effects I experienced were nausea and heartburn. These did go away by the time the sample was finished. I did not lose any weight. I just now recently started back up with Saxenda (my insurance did pay for it, TG!), so when you start, it's at the 1.8 mg. So far, no side effects, hunger is minimal, so I'm thinking I need to increase, but will follow the prescription instructions."

7 / 10
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5 Report
  • Chr...
  • April 13, 2021

For Weight Loss (Obesity/Overweight) "I have now been on Saxenda for 5 weeks and 2 days and on 3 mg for the last 9 days. Some slight nausea in the beginning and some heartburn last week, also some fatigue, but otherwise okay. In the first week, I lost 4 pounds, but in total, I have lost about 9 pounds, and during the last week, nothing at all. I am on a diet of about 1200-1300 kcal/day. I have about 30-35 pounds to lose, a 58-year-old woman with many years of yo-yo dieting. I still have the same cravings and also appetite, but I feel full very fast, so I eat less. Anyone who has experienced that weight loss increases after some time? Or am I a weak responder to the treatment?"

7 / 10
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24 Report
  • Chr...
  • Taken for less than 1 month
  • March 30, 2021

For Weight Loss (Obesity/Overweight) "First week down, I'm down 3 lbs. I originally was not happy about that, but I can feel the difference. I have started to monitor my food on MFP to make sure I am doing it right and up the dose tonight. The first few days, I was pretty nauseous, woke up with heartburn in the middle of the night (injection at night), which was resolved with some peppermint oil. I have been eating between 1200-1500 calories a day, and I find that if I cheat (for experimentation) and have a piece of chocolate, then I'm uncomfortably full for what feels like hours. Make sure you stop eating your meal when you feel the slightest bit of no longer hungry. I read somewhere on here that Saxenda is like weight loss surgery in an injection... I couldn't agree more. I will keep updating!"

10 / 10
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41 Report
  • Mel...
  • Taken for less than 1 month
  • March 21, 2021

For Weight Loss (Obesity/Overweight) "This is my third week on the medication, and I'm down 11 lbs - a miracle for me! Starting weight was 198 lbs at 5'7, and with PCOS, weight loss has been difficult before Saxenda. I no longer crave sugar, and I'm finally that person who can have a square of chocolate and put the rest in the fridge! I haven't cut out any food groups, but it's been a godsend for portion control - I'm simply not hungry. I've only just upped my dose to 1.2 and was on the min dose of 0.6 for 2.5 weeks. I don't think I'll go any higher. Side effects have been constipation and some heartburn, but the positives massively outweigh this. My goal now is to focus on healthy eating, as when I come off, I don't want to be craving sugar, etc. Wish I'd found this sooner!"

10 / 10
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23 Report
  • Hap...
  • February 17, 2021

For Weight Loss (Obesity/Overweight) "On Sept 1, 2020, I was 210 lbs and 5.1 ft tall. The start was terrible. Got all the side effects: headaches, dizzy, nausea, heartburn, no energy, irritable, and bad stomach pains. But I stuck it out. The smaller doses didn’t stop my cravings; I was still hungry, so I ate small healthy snacks and smaller meals. As doses increased, side effects got worse, and constipation set in. I’ve been losing approx 5 lbs per month, but I’m okay with my slow progress. Side effects got better except for heartburn and constipation. I was diagnosed with type 2 diabetes and was given 1 year to turn it around. As of last week, I am no longer diabetic. Today is Feb. 16, 2021, and I am currently 180 lbs. I’ve lost 2 clothing sizes. I give myself small goals to keep myself motivated. There are days I don’t want to even look at food and some days that I still get cravings. But I’m good with only having a small portion to settle my cravings. I walk and climb an average of 3 times per week for 40 min."

8 / 10
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51 Report
  • Mar...
  • Taken for 1 to 6 months
  • January 11, 2021

For Weight Loss (Obesity/Overweight) "I started using Saxenda for a very different problem than obesity. I am slightly overweight and have bulimia, which had been under control for years. When I started a new medication for my depression, I began to gain weight. No matter what I ate or didn't eat, I did not lose a single pound and was always starving. Therefore, the bulimia returned. My doctor prescribed me Saxenda to curb my hunger cravings in the evening. I'm now up to 1.8mg and inject every other day. Since then, the cravings are gone. I don't force myself to throw up anymore and am much happier. I also lost 14 pounds. I am still overweight but much happier again. I hope to stay on Saxenda on a low dose for a while. I had the usual side effects at the beginning: dry mouth, constipation, heartburn, and sulfur burps. Most of it is gone now. The dry mouth remains, but the more water I drink, the better I can use the bathroom to avoid constipation."

10 / 10
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115 Report
  • tst...
  • Taken for less than 1 month
  • March 10, 2020

For Weight Loss (Obesity/Overweight) "Started on Saxenda on Feb 28, down 4 lbs, but have extreme heartburn and stomach sickness. Any suggestions on what to eat to avoid sickness and heartburn?"

4 / 10
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70 Report
  • AHC...
  • Taken for 1 to 6 months
  • September 29, 2019

For Weight Loss (Obesity/Overweight) "I’ve been using Saxenda for almost 3 months. I am using the 3.0 ml dose. I have recently begun experiencing harsher side effects. About 2 months ago, it was constant heartburn (although I already take omeprazole each morning). About 3 weeks ago, I began experiencing vomiting and diarrhea. Has anyone else noticed these side effects this far into using Saxenda?"

8 / 10
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22 Report
  • Mea...
  • Taken for 1 to 6 months
  • August 23, 2019

For Weight Loss (Obesity/Overweight) "I have been on Saxenda for about 3 months. Initially, I had to start below the recommended dose because of nausea, diarrhea, and heartburn. Also, I progressed slowly, slower than recommended due to the same side effects. I have gone from 194 lbs to 170 lbs. I am very happy about the weight loss. It has decreased my appetite and reduced my sugar cravings. I do wonder if I will gain all this weight back when/if I stop. It is quite expensive, so I am sure I cannot afford it for much longer."

7 / 10
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20 Report
  • Que...
  • Taken for less than 1 month
  • July 25, 2019

For Weight Loss (Obesity/Overweight) "I think I have all the horrible side effects of this drug. I have serious heartburn all day and night. Then comes the belching, which smells like rotten eggs. As soon as I try to sleep, the nausea kicks in, then to top it all, explosive diarrhea all night, so I'm not getting any sleep. Yes, I have lost three pounds a week, but the side effects are so miserable I can't live like this."

7 / 10
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26 Report
  • Pol...
  • May 16, 2019

For Weight Loss (Obesity/Overweight) "I've been on Saxenda a little over a month to lose weight, and I've lost almost 15 pounds, which I'm happy about, but most of it has been due to the side effects - nausea, heartburn, and diarrhea. The feeling of hunger is gone and replaced with daily nausea, so that I have to remind myself to eat. The diarrhea and excessive gas that has produced loud, uncontainable belching have made me reluctant at times to eat at all, so as not to have to bolt for a bathroom while chaperoning a field trip, for example. I am extremely nauseated and sleepy in the afternoon, which I haven't experienced since pregnancy (14 years ago!). I have both Polycystic Ovarian Syndrome and Irritable Bowel Syndrome, which have complicated my dietary choices while on this drug. I am exercising regularly and trying to make good food choices. Despite the side effects, I'm planning on staying on this drug for another month or so in hopes that the side effects will eventually subside."

7 / 10
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12 Report
  • Mom...
  • Taken for less than 1 month
  • February 23, 2019

For Weight Loss (Obesity/Overweight) "I started the pen in late January. I’m a mom of two (19 months and 3-year-old) so I rarely have time to exercise. I started this with low expectations, but it has been amazing. You will have no appetite, but you will have nausea and headaches at first. This is your body’s way of telling you it needs fuel. Try eating small snacks during the day. You basically have to force yourself to eat something. I found that eating about every 3-4 hours (almonds, fruits, yogurt) will stop the nausea and headaches. Drink plenty of water because you will get dehydrated. I had horrible sulfur burps and heartburn for a couple of days. Nothing a little Pepto couldn’t cure. I’m on the 2.4 dosage and have lost 15 lbs in one month. I’m going to try to start walking more once the weather permits. I started at 238 lbs. My goal is to be under 200."

9 / 10
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59 Report
  • Bil...
  • Taken for 6 months to 1 year
  • February 16, 2019

For Weight Loss (Obesity/Overweight) "It's the only thing in 40 years that helped me lose weight. I have lost about 25 lb, but how do you get around the tremendous heartburn? It almost mimics a heart attack. By the way, I am a heart patient."

9 / 10
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15 Report
  • chi...
  • Taken for less than 1 month
  • December 28, 2018

For Weight Loss (Obesity/Overweight) "Saxenda has really helped with stopping salty, sweet craving. I've taken it for one week, lost 7 pounds. I feel full most of the time. I have slight heartburn occasionally. I'm making healthier food choices and working on increasing physical activity. So far, I am encouraged. I have to see if insurance will cover Saxenda."

7 / 10
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14 Report
  • Laa...
  • Taken for less than 1 month
  • November 9, 2018

For Weight Loss (Obesity/Overweight) "I’ve been on it for 4-5 weeks. Been experiencing heartburn and acidity around the 3rd week till now. I can’t sleep from being nauseated all the time. Woke up vomiting twice. I get stomach aches almost all the time."

4 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.