Skip to main content

Saxenda and Headaches: What Users Say

Headaches: mentioned by 156 users (10.8%)

Based on user experiences from 1,448 Saxenda reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 38.2%
constipation 12.8%
headaches 10.8%
tiredness 8.1%
vomiting 7.7%
diarrhea 7.5%
fatigue 6.8%
heartburn 4.4%
loss of appetite 4.1%
sick 4.1%

Reviews for Saxenda

Commonly mentioned side effects
  • Zos...
  • Taken for less than 1 month
  • June 12, 2023

For Weight Loss (Obesity/Overweight) "I'm currently in my third week of Saxenda, but it doesn't feel like I've lost any weight. The side effects have been quite bad. I experience nausea and significant indigestion. I find myself eating Tums like crazy, especially at night. I also have a daily headache and an overall feeling of malaise. My energy levels are low, and I could easily sleep all day or stay in bed. If I cough too much, I'm at risk of vomiting. It's hard to say if it's worth it at this point. I'm hopeful that this terrible overall feeling will eventually go away and that my body will adapt, but the lack of weight loss is discouraging. Maybe Saxenda isn't the right drug for me. It's difficult to tell. I still have four pens left, so I'll try to stick with it. Interestingly, I have absolutely no appetite, which makes it even stranger that I don't feel like I've lost any weight. It's frustrating. I was really hoping for better results."

4 / 10
Was this helpful?YesNo
5 Report
  • 3...
  • Taken for less than 1 month
  • May 22, 2023

For Weight Loss (Obesity/Overweight) "I have been taking this for 3 weeks now, but I don’t feel well most of the time. Nausea, headaches, and no appetite. I have lost over a stone, but I wonder if this sick feeling is worth it. One of the times, I was in bed for two days because I felt so sick. It’s a quick weight loss, but will it be maintained after I stop the injections?"

5 / 10
Was this helpful?YesNo
3 Report
  • Chr...
  • Taken for 1 to 6 months
  • February 24, 2023

For Weight Loss (Obesity/Overweight) "My nurse practitioner gave me Saxenda because I have been working out and not seeing results. I am 4 weeks in and still no results. I guess I'm just supposed to be fat forever. I don't think I eat that much, and everyone says I work out enough. I recently stopped eating dinner and noticed that this is the only time I can lose a pound. I mean a pound!!! It's not fair. I'm not trying to win a beauty contest, I just want to be healthy because heart disease and diabetes run in my family. I have two beautiful granddaughters I need to stick around for!!! Can anyone make any suggestions??? THX!!! P.S. oh, and these headaches just won't go away!!!"

1 / 10
Was this helpful?YesNo
4 Report

Frequently asked questions

  • Anonymous
  • Taken for 1 to 6 months
  • November 20, 2022

For Weight Loss (Obesity/Overweight) "I’ve been on Saxenda for 5 weeks now. I have so far lost 3 kilos. And this I believe is due to the constant nausea I have been having on a daily basis. I’ve also had the worst headaches since starting Saxenda that just don’t go away. My cravings have disappeared. And so has my appetite. I eat a 1/4 of what I used to. I’m currently on 2.4 mg and have stayed on this dosage for a 2nd week hoping that the headaches would ease. But unfortunately, that hasn’t happened. So far, I’m disappointed that I haven’t lost more weight. And am wondering if this is all worth it."

2 / 10
Was this helpful?YesNo
3 Report
  • Emm...
  • Taken for 1 to 6 months
  • November 1, 2021

For Weight Loss (Obesity/Overweight) "I have been using Saxenda for 2 months and have not lost any weight. I do not find that it lowers my appetite at all. Last year, the doctor had me try Ozempic, which was very successful for me for approximately 6 months, then it stopped being as effective. Since then, I have tried other medications, but nothing has worked. My side effects are mostly rapid heart rate and a slight headache, but no stomach issues."

1 / 10
Was this helpful?YesNo
6 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Thu...
  • Taken for less than 1 month
  • October 5, 2021

For Weight Loss (Obesity/Overweight) "Today is my 8th day on Saxenda. I have not felt sick so far, but my appetite is suppressed a little. Sometimes I get nauseous. Since I increased my dose yesterday, today I'm feeling a bit of a headache. Overall, I feel a lot lighter, have not lost weight, but my body feels lighter than usual. I'll keep on it for 3 months and see how things go. I am not able to exercise yet, as my body is quite heavy. I am 121 kg, I need to lose at least 30 kg and maintain. Overall, I am happy with Saxenda, even though I have not seen any results yet."

7 / 10
Was this helpful?YesNo
2 Report
  • Jan...
  • Taken for 1 to 6 months
  • September 30, 2021

For Weight Loss (Obesity/Overweight) "Expensive, but I lost 16 stone on my own, diet and exercise, over 18 months and put it back on after injury, and after trying to get started again I’m back. 50 lb down, 35 during Saxenda in 10 weeks. Awful taste, terrible constipation and thirst and headaches, but no real cravings. And if I want a meal I can have it; I just don’t eat as much. It is worth it if you have tried and failed to lose weight, and if you can cope with the side effects. I’m feeling far more mobile, fairly stable mood-wise but you do have to help yourself. I’ll start some light exercise, and I need to eat the right type of food or I don’t lose, but it does work!"

8 / 10
Was this helpful?YesNo
4 Report

More FAQ

  • pat...
  • Taken for less than 1 month
  • September 5, 2021

For Weight Loss (Obesity/Overweight) "I'm almost through week 2, and I'm at the 1.2 dose. I experimented with taking it at night, midday, and morning. For some reason, my body likes the morning. I had terrible nausea and headaches. But if I take it in the morning, then that either doesn't happen or happens while I'm asleep later on. I've been walking 60-90 minutes per day in the morning. I don't use a scale, so I don't know for certain my starting weight and current weight. Probably started around 95 kg (165 cm). I feel lighter. I can walk farther and faster. I don't get out of breath. My chest is slightly smaller. My face looks slightly thinner. I'd guess that I've lost a kg or two in the short time that I've been on it. I have to eat small meals. I can't really eat a 'meal' like I used to. Just snacking on fresh veggies and a cracker every now and then to settle my stomach. White fish, spinach, etc. No cravings for sugary foods or alcohol. My skin looks more radiant. I pay only 50 GBP per month for the Saxenda pen."

10 / 10
Was this helpful?YesNo
4 Report
  • Msc...
  • Taken for 1 to 6 months
  • August 28, 2021

For Weight Loss (Obesity/Overweight) "41 y/o female, 344 lbs starting weight. 6 weeks taking Saxenda and I’ve lost 17 lbs. I have struggled with obesity my whole life. I’ve found this medication challenging to take, but it works, and I’m going to see it through. The nausea and headaches in the first few weeks were super rough. That calmed down and was replaced with constipation and diarrhea for several weeks, which was pretty awful at times. It seems to have leveled off now, but I do still get uncomfortable if I eat too much. I lost a lot of weight in the first few weeks and then started plateauing, but I’m trending down again. This stuff works—I find it very helpful in keeping me on smaller portions and craving healthier foods. My goal is to get into the comfortable habit of eating less and eating better and not wanting to overindulge. I’m addicted to the pleasure of food, and that is a tough cycle to break. Hopefully, the worst of the side effects are over now."

7 / 10
Was this helpful?YesNo
6 Report
  • So ...
  • Taken for 1 to 6 months
  • July 22, 2021

For Weight Loss (Obesity/Overweight) "I started Saxenda two and a half months ago, and I have lost 32 pounds. I am very lucky that I had very minimal side effects. I had some headaches at the beginning, but they were manageable. I am up to the 3 ml dose, and I am happy with the results so far."

10 / 10
Was this helpful?YesNo
5 Report
  • HGa...
  • Taken for less than 1 month
  • July 18, 2021

For Weight Loss (Obesity/Overweight) "On week 3 this coming Tuesday and lost 8.2 lb. I used to be a runner, stopped due to injury and put on 2 stone. I do weight training but no cardio. My BMI hit 27 and I felt so miserable. UK private prescription service cost £55. The first day I accidentally overdosed as I didn’t feel the injection, so I assumed I had messed up and did another one. Big mistake - felt rough and threw up. Since then, I have stuck to the 0.6 mg. At the rate I am dropping, I won’t increase the dose. Slight headache, but the weather is hot ATM and I should drink more water. Starting to fit into my clothes and my confidence is back. Next goal is to start running again. Once I regain enough fitness to sustain a good pace/distance, I plan to come off Saxenda. I won’t rule out a short cycle on it in the future, for me, it has kickstarted my weight loss when all else has failed. I felt I was climbing Everest trying to lose the weight with diet and gym as the progress was often slow to nothing! Now I feel it is less overwhelming!"

10 / 10
Was this helpful?YesNo
10 Report
  • Lin...
  • Taken for less than 1 month
  • July 16, 2021

For Weight Loss (Obesity/Overweight) "I lasted 24 hours on this stuff. The following morning after my 1st injection, I had vomiting, diarrhea, abdominal pain and bloating, headache. I haven't been this sick in years... awful experience."

1 / 10
Was this helpful?YesNo
6 Report
  • Ban...
  • July 12, 2021

For Weight Loss (Obesity/Overweight) "Have been taking Saxenda for about a month but haven’t been able to up my dose to 3.0 since I’ve been having horrible severe headaches and nausea, watery diarrhea, and vomiting nonstop for weeks. I have no energy. I’m miserable. I wonder, will this be worth it? :( I’ve lost about 4 kg, that’s all, and I can barely eat or do anything from how sick and weak I am. Was very excited to try the medication, but I’m so upset. Any recommendations? :("

4 / 10
Was this helpful?YesNo
18 Report
  • Pat...
  • June 5, 2021

For Weight Loss (Obesity/Overweight) "I have been on Saxenda for 1 week now and just increased my dose to 1.2 today. From the first day I experienced a suppressed appetite, which was great. When I started last week, I was 120 kg, and today I weighed in at 118 kg. I am happy that it is heading in the right direction. At day 5 of injections, I became very ill with reflux, vomiting, headache, burping, no energy, bloating, and abdominal pain... a horrible feeling. Because of this, I have not exercised at all. Today on day 8, I feel a little better, but the bloating still remains and is uncomfortable. I will stick with it because I do have high hopes for this medication. In Australia, I’m paying around $380 plus needles (100 for $19). It is suppressing my hunger and cravings, my body wants fruit and veg, anything else feels wrong and does not satisfy. Stay hydrated. I'm off to the chemist to hopefully find some relief for my bloated tummy... it’s like I’m 7 months pregnant!! Hope to follow up with some good news next week!!"

8 / 10
Was this helpful?YesNo
79 Report
  • Ema...
  • Taken for less than 1 month
  • May 28, 2021

For Weight Loss (Obesity/Overweight) "This was a really bad experience. Took Saxenda for 3 days, only a dose of 0.6, and ended up with side effects of severe nausea, vomiting, watery diarrhea, stomach ache, headache. Could not even drink water due to severe nausea, got dehydrated. Stopped the drug, and the side effects lasted for 5 more days! Would never recommend this drug to anyone."

1 / 10
Was this helpful?YesNo
7 Report
  • Luc...
  • May 10, 2021

For Weight Loss (Obesity/Overweight) "I started Saxenda at 167 pounds, and I lost 6 pounds in 7 days. Today is 14 days, and I am at 156 lb. I mean the first 2 weeks = 11 pounds. But the side effects are ugly. I cry, I have nausea, headache. I removed everything today. For me, the injections are obtained for free by your doctor if your BMI is from 29 up. In Mexico, it is valued at 200 dollars, Canada, 400, and the USA, 1800."

9 / 10
Was this helpful?YesNo
8 Report
  • Fer...
  • Taken for less than 1 month
  • May 9, 2021

For Weight Loss (Obesity/Overweight) "I'm only on day 3 of Saxenda and have lost 3 lb. I'm getting headaches and a dry mouth, but nothing I can't cope with. I only seem to be able to eat around lunchtime. I can't explain it, when my meal is in front of me, I don't feel full or bloated - I just can't eat any more than half of a small portion. I haven't had that empty, sickly feeling from not eating enough and haven't snacked or felt the urge to snack at all."

10 / 10
Was this helpful?YesNo
10 Report
  • Fay...
  • Taken for 1 to 6 months
  • May 5, 2021

For Weight Loss (Obesity/Overweight) "I am just starting week 6, and down 10 lbs. This hasn't been a rush, and I am way less than I have ever been. Not on the full dose as of yet, at 2.4 and 4 clicks. It is shocking how much of an effect it can have on you. If I eat too late, I wake up with horrible acid reflux. I attempted 3 ml, and the headache I got was next level... not migraine level, but not fun and wasn't quelled by meds. I love this drug, I know my loss is slower than many others, but I am working out more and harder and loving how I am feeling. Down 4 inches on my body as well... heck yes!!!"

10 / 10
Was this helpful?YesNo
8 Report
  • Fat...
  • May 2, 2021

For Weight Loss (Obesity/Overweight) "I was excited to have Anthem Blue Cross cover this medication. I'm 42 years old, 5 feet 6 inches tall, and 175 lbs. I always take the latest diet craze and have had mixed results, but never side effects like this. It is debilitating, and I'm not sensitive to new meds. Man... I don't think I can hang with it at all! It's just me and the dogs, and I'd really need someone to take care of me if I was going to take this awful drug. Of course, you lose weight. You're too damn sick to take a sip of water, puke your own spit, and your head hurts like a mix of a migraine and allergies all in one. I can't recommend this drug to anyone at the dose recommended. I am a glutton (LOL) for punishment and carbs, so I'll probably try to take a super low dose as soon as I get my ducks in a row to be able to take care of myself and my dogs in the event the side effects are just as bad as they were on the recommended dose."

1 / 10
Was this helpful?YesNo
7 Report
  • Suz...
  • Taken for 1 to 6 months
  • April 29, 2021

For Weight Loss (Obesity/Overweight) "I'm on my 5th week, 3 ml. At first, I felt a bit of nausea, headaches, and an upset stomach in the first few weeks, but it went away. I feel thirsty sometimes, and my hunger cravings have lessened, so I'm eating less, just trying to make better choices when I do eat. Overall, it's a bit expensive, but so far, so good. Was 150 kg, now 147 kg, so I have lost 3 kilos."

8 / 10
Was this helpful?YesNo
5 Report
  • IRe...
  • Taken for less than 1 month
  • April 8, 2021

For Weight Loss (Obesity/Overweight) "I’ve been on Saxenda for just over a week. Admittedly, I only injected the 0.6 dosage for two days before I increased it to 1.2 because I wasn’t “feeling” anything. I did 1.2 for the rest of that first week and increased to 1.8 today. I have noticed a significant decrease in appetite over the past few days. I haven’t started working out yet. One night I woke up with a really bad taste in my mouth. I did an internet search and found out it’s a common side effect. I’m also experiencing a bit of constipation and a couple of headaches but no nausea. My goal is to lose 100 lbs, and I’d really like to do it with bariatric surgery. Hoping Saxenda will help me out."

8 / 10
Was this helpful?YesNo
31 Report
  • Chr...
  • Taken for less than 1 month
  • March 10, 2021

For Weight Loss (Obesity/Overweight) "Female, 154 cm and 95 kg, 57 years. Overweight as a child, dieting most of my life since the age of 12, and normal weight between teenage years and after the third child. After the fourth child, extreme problems to lose weight, and even worse after menopause, and also gaining weight continuously despite a controlled intake. Been in therapy to learn how to eat normally after years of yo-yo dieting. Still unable to lose weight. I started Saxenda on Sunday, March 7, dosage 0.6 mg. Felt some very slight nausea and headache the day after. Thereafter, absolutely nothing, and I still have cravings, still the same appetite. I understand it will take some time, but is there a correlation between side effects and weight loss? I hope I finally can expect some appetite control and weight loss in a while. Eating balanced meals around 1100 kcal/day."

6 / 10
Was this helpful?YesNo
2 Report
  • DJa...
  • Taken for less than 1 month
  • March 1, 2021

For Weight Loss (Obesity/Overweight) "I started Saxenda 2/24/21 and so far on 3/1/21, I have lost 6.2 pounds. The only side effects that I have had are headaches and fatigue. It’s not horrible for me, and I’m able to continue. I’m still on the 0.6 dosage and look forward to losing an additional 29 pounds. Good luck to everyone ❤️"

10 / 10
Was this helpful?YesNo
96 Report
  • Hap...
  • February 17, 2021

For Weight Loss (Obesity/Overweight) "On Sept 1, 2020, I was 210 lbs and 5.1 ft tall. The start was terrible. Got all the side effects: headaches, dizzy, nausea, heartburn, no energy, irritable, and bad stomach pains. But I stuck it out. The smaller doses didn’t stop my cravings; I was still hungry, so I ate small healthy snacks and smaller meals. As doses increased, side effects got worse, and constipation set in. I’ve been losing approx 5 lbs per month, but I’m okay with my slow progress. Side effects got better except for heartburn and constipation. I was diagnosed with type 2 diabetes and was given 1 year to turn it around. As of last week, I am no longer diabetic. Today is Feb. 16, 2021, and I am currently 180 lbs. I’ve lost 2 clothing sizes. I give myself small goals to keep myself motivated. There are days I don’t want to even look at food and some days that I still get cravings. But I’m good with only having a small portion to settle my cravings. I walk and climb an average of 3 times per week for 40 min."

8 / 10
Was this helpful?YesNo
51 Report
  • Lau...
  • January 15, 2021

For Weight Loss (Obesity/Overweight) "I started Saxenda 2 months ago. I can’t get over the headaches and nausea I get when I take it! I lost 38 pounds but feel awful. I wonder if all this misery is worth it. I will post again when I increase my dose."

1 / 10
Was this helpful?YesNo
302 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.