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Saxenda and Diarrhea: What Users Say

Diarrhea: mentioned by 109 users (7.5%)

Based on user experiences from 1,448 Saxenda reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 38.2%
constipation 12.8%
headaches 10.8%
tiredness 8.1%
vomiting 7.7%
diarrhea 7.5%
fatigue 6.8%
heartburn 4.4%
loss of appetite 4.1%
sick 4.1%

Reviews for Saxenda

Commonly mentioned side effects
  • sjs...
  • Taken for 1 to 6 months
  • June 25, 2024

For Weight Loss (Obesity/Overweight) "I didn’t think Saxenda would work for me as I mainly eat out of boredom. My start weight in March ‘24 was 83 kgs, and in 3 months, June ‘24, it is 77 kgs. I find I can’t drink much alcohol, and my meal portions are smaller. I’ve had a couple of episodes of diarrhea when I’ve overindulged, and early on, heartburn was quite prevalent, but I found Gaviscon worked immediately. I haven’t been able to do any exercise due to a bad leg, so I’m happy to have lost the 6 kgs. The injections are simple to do, the biggest downside for me is the cost, and I’m concerned about putting weight back on when I stop taking it. So, apart from the cost, I’m very happy with Saxenda."

10 / 10
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  • Lyn...
  • Taken for 1 to 6 months
  • April 20, 2023

For Weight Loss (Obesity/Overweight) "Discontinued after taking for 4 weeks, the side effects are unbearable. Nauseated almost daily, multiple episodes of vomiting, and horrible diarrhea. I have lost approximately 10 pounds, however, the side effects are definitely not worth taking."

2 / 10
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  • Mel...
  • Taken for less than 1 month
  • March 24, 2023

For Weight Loss (Obesity/Overweight) "I’m on day 12. I didn’t notice any difference for the first few days on the 0.6 mg dose, so I increased it to 1.2 mg on day 4 and am now on 1.8 mg. I’m not as hungry as I used to be all the time, but I still get hungry when I wake up and in the evening. I have had bad acid reflux, and when I increased the dose, I had diarrhea for a day or two after eating. I have lost 2 kgs so far, was hoping to feel a little more appetite suppressant, but maybe once the dose increases again. I’m very conscious of what and how much I’m eating now."

7 / 10
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Frequently asked questions

  • Aus...
  • September 24, 2022

For Weight Loss (Obesity/Overweight) "I had a great first week on .06. Suppressed appetite, able to eat healthy and stick to a protein diet with salad and fruit. No nausea. Took at night. Lost 1.5 kg. Started 1.2 dose second week. Not great result. Excessive burning, diarrhea, abdominal pain and tenderness, tired and unable to stick to a healthy diet due to diarrhea. Going back to .06 dose. Afraid of pancreatitis as my mum just got over this from Metformin."

5 / 10
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  • Cur...
  • Taken for less than 1 month
  • September 7, 2022

For Weight Loss (Obesity/Overweight) "It is the worst drug I have ever taken! I was prescribed Saxenda by a GP to help with weight loss. By Day 5, I had violent vomiting for 8 hours, followed by diarrhoea. I ended up with broken capillaries on my face from the vomiting. I continued on but opted to stay on the lower dose. 2 days later, I had diarrhoea again. Bright yellow and pouring out of me. 4+ times an hour for 48 hours. I would not recommend this to anyone."

1 / 10
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  • Sal...
  • Taken for 1 to 6 months
  • August 12, 2022

For Weight Loss (Obesity/Overweight) "I’m on week 5 and still not managed to get to the full dose as the side effects have been severe. I started well in the first couple of weeks, losing 3 lbs a week, feeling very positive with no side effects. Then I started with severe diarrhea and very bad stomach cramps, feeling very fatigued, and I haven’t lost any weight in the last three weeks. I am presently on the 2.4 dose. I have experienced bad itching, redness, and discomfort at the injection site, and this has gotten worse as the dose has increased. I have decided to use the pens that I have purchased and not to continue, it would appear I am one of the 15% who do not suit Saxenda."

2 / 10
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  • Anonymous
  • May 25, 2022

For Weight Loss (Obesity/Overweight) "Took the starting dose, and on day 5, started with the most horrendous diarrhea. Had to stop taking it as I felt absolutely ill."

2 / 10
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More FAQ

  • Mau...
  • Taken for 1 to 6 months
  • March 24, 2022

For Weight Loss (Obesity/Overweight) "I'm a 43-year-old woman, 5'6. Originally, I weighed 210 pounds. I started Saxenda 30 days ago. I now weigh 193 pounds. I am currently injecting 1.8 and still have 10 days left on that dose. Not much side effects, just a little nausea. I did get diarrhea a few times after I consumed carbohydrates. I have no appetite and am never thirsty, so I need to remind myself to hydrate. A few times I didn't hydrate enough, which led to constipation. I also try to walk 3k every evening, getting my 10,000 steps in a day. It is definitely working for me."

10 / 10
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9 Report
  • CEK...
  • Taken for less than 1 month
  • February 20, 2022

For Weight Loss (Obesity/Overweight) "Started on the 0.6 with no side effects. Lost 4 kilos in a week. Definitely no desire to eat. Made sure I drank lots of water. Increased my dose to 1.2, and by the next day, I had the most severe diarrhea I have ever had. I couldn’t go to work for 4 days. I have needed to stop my dosage just so I can get back to work but plan on going back on the lowest dosage tomorrow. I am hoping I can stay on this lowest dose and still lose weight. I have lost 6 kilos in 2 weeks, and I intend to continue. Would love to hear back from anyone that has stayed on the lowest dose and still continued to lose the weight."

7 / 10
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  • Jum...
  • Taken for less than 1 month
  • November 3, 2021

For Weight Loss (Obesity/Overweight) "Nausea and diarrhea too much to bear. This drug is awful. Would definitely not recommend. Dose 0.6 mg."

1 / 10
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  • Msc...
  • Taken for 1 to 6 months
  • August 28, 2021

For Weight Loss (Obesity/Overweight) "41 y/o female, 344 lbs starting weight. 6 weeks taking Saxenda and I’ve lost 17 lbs. I have struggled with obesity my whole life. I’ve found this medication challenging to take, but it works, and I’m going to see it through. The nausea and headaches in the first few weeks were super rough. That calmed down and was replaced with constipation and diarrhea for several weeks, which was pretty awful at times. It seems to have leveled off now, but I do still get uncomfortable if I eat too much. I lost a lot of weight in the first few weeks and then started plateauing, but I’m trending down again. This stuff works—I find it very helpful in keeping me on smaller portions and craving healthier foods. My goal is to get into the comfortable habit of eating less and eating better and not wanting to overindulge. I’m addicted to the pleasure of food, and that is a tough cycle to break. Hopefully, the worst of the side effects are over now."

7 / 10
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6 Report
  • Lin...
  • Taken for less than 1 month
  • July 16, 2021

For Weight Loss (Obesity/Overweight) "I lasted 24 hours on this stuff. The following morning after my 1st injection, I had vomiting, diarrhea, abdominal pain and bloating, headache. I haven't been this sick in years... awful experience."

1 / 10
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  • Ban...
  • July 12, 2021

For Weight Loss (Obesity/Overweight) "Have been taking Saxenda for about a month but haven’t been able to up my dose to 3.0 since I’ve been having horrible severe headaches and nausea, watery diarrhea, and vomiting nonstop for weeks. I have no energy. I’m miserable. I wonder, will this be worth it? :( I’ve lost about 4 kg, that’s all, and I can barely eat or do anything from how sick and weak I am. Was very excited to try the medication, but I’m so upset. Any recommendations? :("

4 / 10
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18 Report
  • Car...
  • July 1, 2021

For Weight Loss (Obesity/Overweight) "Ok, I am so excited! Started taking Saxenda injections for almost 4 weeks now. I am down 20 lbs. However, I am still at the lowest dose, and OMG (this is going to be TMI), I got the worst, I mean the worst, explosive diarrhea ever! Every 10-15 minutes, I barely made it to the bathroom. My appetite was non-existent, and other than the severe side effect, I would recommend this to anyone who wants to lose weight. Imodium and Metamucil help greatly, and I will continue with my 30 lb more weight journey. I hope those won’t be put off by my experience, it’s just that it is my experience. My reaction was a very severe one, but it is controlled."

10 / 10
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25 Report
  • Cam...
  • Taken for less than 1 month
  • June 28, 2021

For Weight Loss (Obesity/Overweight) "I am on week 3. Week 1 @ .6 mg and now 1.2 mg. Had a few days of diarrhea the first week. Only once a day. Then my body adjusted and no bad side effects. I am 5'6", 200 lbs. I have hypothyroid and menopausal issues. Kept gaining weight no matter what I did. I already lost 10 lbs. My appetite is suppressed and I eat small quantities. I do feel thirsty a lot, so that helps me drink more water. I also don't crave sweets like I used to."

9 / 10
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  • Ema...
  • Taken for less than 1 month
  • May 28, 2021

For Weight Loss (Obesity/Overweight) "This was a really bad experience. Took Saxenda for 3 days, only a dose of 0.6, and ended up with side effects of severe nausea, vomiting, watery diarrhea, stomach ache, headache. Could not even drink water due to severe nausea, got dehydrated. Stopped the drug, and the side effects lasted for 5 more days! Would never recommend this drug to anyone."

1 / 10
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7 Report
  • Smi...
  • Taken for 1 to 6 months
  • May 10, 2021

For Weight Loss (Obesity/Overweight) "I’ve been on Saxenda for a month now and lost 12 pounds. I’ve increased my movement and lowered my calorie intake. I’m at 1.8 mg and have started feeling most of the common symptoms: nauseous, diarrhea, and vomiting. I’m hoping my body will adjust soon."

7 / 10
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18 Report
  • Stu...
  • Taken for less than 1 month
  • May 8, 2021

For Weight Loss (Obesity/Overweight) "Tried Saxenda after years of trying other things and failing. COVID lockdown in March 2020 led to 45 lbs weight gain by March 2021. In April 2021, I started on Saxenda at 0.6 mg for 10 days. Lost 3 lbs; like the others above, constant craving and binge eating went away like magic! Including coffee aversion. Upped the dose to 1.2 mg; by day 5, I had severe GI issues - woke up in the middle of the night to vomit, constant diarrhea, burps that smell and taste like rotten eggs. Sat in bed sick and did not eat for 4 days. Because I have kids and a full-time job, these side effects are a deal breaker for me. Either they had to go, or Saxenda had to go. Talked to my doc and dropped the dose back to 0.6 mg, which I will stay on for 2 more weeks before trying the 1.2 mg dose again. I never got to the peak dose of 1.8 mg and am not sure my body can tolerate. After 25 days, I lost 10 lbs, but it may be because I ate almost nothing for 10 days of feeling sick. I am not sure if the lower dose will work, but I will try."

7 / 10
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  • Die...
  • March 30, 2021

For Weight Loss (Obesity/Overweight) "Am now up to 1.8 mg and feeling really unwell, loose bowels to like water tap 30 minutes after I eat or drink anything. Feeling really, really tired, exhausted, pain just under my left rib, either liver or pancreas, I think? So, spoke to my Dr, and she thinks my level is 1.2 mg, see how I go. My appetite has gone. So, it does work, but I don’t think I need such a high dose."

3 / 10
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  • Exo...
  • March 11, 2021

For Weight Loss (Obesity/Overweight) "Works great, I lost 8.4 lbs in the 1st week, but at a cost. Never so sick in my life! Threw up everything but my spleen! Started out with the belching. Sounded like an old drunk. Then the bloat began. My stomach looked and felt like I swallowed a hot air balloon. Next, the diarrhea, nothing but pure liquid. At this point, I was a little concerned about becoming dehydrated. Finally, the vomiting, the violent, whatever you ate was coming out of your nose kind of vomiting. I was like, 'There is no way a medicine could make a person feel this bad!' But it can, and did! However, I still feel this could be a good weight loss solution, especially since I have high BP, and this doesn't have stimulants and is 'safer.' Reading over other reviews, some people are having great luck with it. My doctor called me in Zofran, and I'm only going to do 0.3 every other day to see if my body adjusts. If I don't see an improvement in 2 weeks, I will just accept this is not a medication for me and go another route."

6 / 10
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46 Report
  • Tee...
  • Taken for less than 1 month
  • March 8, 2021

For Weight Loss (Obesity/Overweight) "I have been on this for 10 days and have lost 8 pounds. I have zero appetite. I force myself to eat, but I am not reaching 1K calories per day. This is a huge issue because the lack of calories is compounding the fatigue issue. I just changed bed sheets and a duvet, and it took 45 minutes because I was exhausted. When I increased my dosage to 1.2, holy diarrhea! I am lactose intolerant, and it felt as though I had eaten a bowl of ice cream. I now take Lactaid before the injection because the cramps were awful. I have also noticed some things that look like hives, but not at the injection site. This is hard. There has to be a happy medium. If I could exercise, the weight would be falling off. But, alas. I have no energy."

7 / 10
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  • Cha...
  • March 4, 2021

For Weight Loss (Obesity/Overweight) "Started Saxenda last week - 0.6 mg decreased appetite the second day. I’ve noticed a HUGE difference in wanting to eat and snacking. The first week I did nothing different (apart from food control) and lost 5 lbs. This week I’m on 1.2 mg. I’ve been more active already, so looking forward to seeing the difference when I weigh on Monday. No severe side effects, nauseous for the first few days of taking it, real bad egg burps for 1-2 days last week combined with very loose bowels. Other than that, fine. The burps are back today, but it’s not unbearable. Looking forward to more weight loss!"

8 / 10
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18 Report
  • Chr...
  • Taken for less than 1 month
  • February 18, 2021

For Weight Loss (Obesity/Overweight) "2 days in on 0.6 mg and the nausea, vomiting, stomach pains, diarrhea, sulfuric burps have hit me hard. My stomach was so painful last night that I’ve decided to discontinue. It feels like it is bad for my body. You may be someone who doesn’t suffer from the severe side effects, but I did, and it was horrendous. An expensive mistake."

2 / 10
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  • Zoe...
  • Taken for less than 1 month
  • September 2, 2020

For Weight Loss (Obesity/Overweight) "I started Saxenda at 349 lbs. and an insulin-dependent diabetic. I've been on it before, go a couple of months and have to go off it to reset my body due to side effects. Each time I go back on, the side effects are worse and I have more of them. I don't have a scale at home so I don't know if I've lost any weight. Right now, I have had one critical low that could have killed me but was treated in time. Constant nausea and gagging, vomiting on occasion but always feeling like I need to. Diarrhea is epic, and so frequent that I experience bleeding. I know if I continue, the constipation will take over and that will get VERY bad. The exhaustion is constant. The side effects are severe and I don't know if I'll be able to stay on it this time. They keep getting worse."

4 / 10
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64 Report
  • Anonymous
  • Taken for less than 1 month
  • August 20, 2020

For Weight Loss (Obesity/Overweight) "Just finished my 3rd week on Saxenda, about to start the 2.4 dose tomorrow. Result: nothing. No side effects e.g. nausea, diarrhoea, stomach pains, dizziness. Just nothing. No weight loss except one pound. Still have the same desire to eat and however much I eat, I don’t feel sick at all, like some people. £320 for what? I still weigh 13 stone. Someone tell me where I am going wrong. Thought I wasn’t injecting properly, but consulted my GP nurse and she says it’s fine. Somebody please help me."

1 / 10
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562 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.