Skip to main content

Hydrochlorothiazide and Nausea: What Users Say

Brand names: Microzide, Esidrix, Ezide, Inzirqo, Hydro Par Carozide Diaqua Aquazide H

Nausea: mentioned by 10 users (5.4%)

Based on user experiences from 185 Hydrochlorothiazide reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 13.0%
tiredness 8.6%
headaches 8.1%
swelling 8.1%
dry mouth 7.0%
cramps 6.5%
fatigue 6.5%
frequent urination 6.5%
weakness 5.9%
nausea 5.4%

Reviews for Hydrochlorothiazide

Commonly mentioned side effects
  • And...
  • July 12, 2017

For High Blood Pressure "Worked for me by day 2, my BP now 125/76. I had been on a calcium channel blocker (amlodipine (Norvasc)) for 9 years, and my hair had thinned so badly. When I finally found out that hair loss is a known side effect of amlodipine, I barely took the medication anymore. I started going to a new doc, who was surprised that my previous doc had not tried a diuretic before putting me on a calcium channel blocker. She started me on 25 mg and told me to take it in the morning, and eat foods with lots of potassium to avoid cramping in my muscles, and drink water because I was probably going to start feeling dehydrated, with a headache. I followed her directions, and after feeling slightly nauseous the first couple of days, I feel great."

9 / 10
Was this helpful?YesNo
62 Report
  • kel...
  • Taken for 1 to 2 years
  • October 12, 2024

For High Blood Pressure "I took this for 1 year for my blood pressure and edema in my legs due to being overweight. Changed my lifestyle, cut out Gatorade, then I believe I started getting dehydrated. A week ago, I almost had to go to the ER due to dizziness, which got worse, then weird numbness, feeling like I was about to go unconscious, sweating, slight nausea, VERY weak. Stopped medicine 5 days ago, re-hydrated with Gatorade, OJ, eating bananas, and now am back to normal. Will never take this medicine again, I felt like I was going to die, very scary. If you must take this, stay very well hydrated and make sure potassium, magnesium, and electrolyte levels are all stable. This medication does what it's supposed to do, but side effects can be very dangerous."

5 / 10
Was this helpful?YesNo
7 Report
  • Kim...
  • Taken for 1 to 6 months
  • November 1, 2015

For High Blood Pressure "I was diagnosed with HBP in late August and was prescribed HCTZ. For the past two months, I experienced nausea and dizziness almost every single day. On the 5th day of taking HCTZ, I got numbness on my scalp, which did go away. Still scary! I traveled with a huge water bottle everywhere I went for fear of becoming dizzy/lightheaded. Eating became a concern as my dizzy/lightheaded feelings were overwhelming after eating or if I waited too long to eat. I had an increase in migraine episodes. I barely got any before, and I had 4 episodes in the 2-month period. I already had cervical neck pain, but this medicine made it worse. I had to use a topical muscle rub and take Tylenol (one dose) almost every day. Needless to say, this medicine was not for me."

4 / 10
Was this helpful?YesNo
62 Report

Frequently asked questions

  • Rob...
  • Taken for less than 1 month
  • August 27, 2015

For High Blood Pressure "Prescribed HCTZ 25 mg a week ago today. This is my first experience with the drug. My BP was high and erratic, the drug is supposed to flush the excess salt from my system and help lower my BP. The first six days were fine, my BP was stabilizing and steadily decreasing. I didn't have a problem with excessive urination because I take the pill at night before bed. I also lost water weight (5 lbs. approx.). The adverse effects started today, day seven. I woke up feeling congested and dry in my right nostril and had a dry BM (which never happens). I am also lightheaded with mild nausea. This medication is not for me. I'll work more diligently on alternative ways to lower my BP."

4 / 10
Was this helpful?YesNo
63 Report
  • Boo...
  • Taken for less than 1 month
  • January 29, 2023

For High Blood Pressure "I started taking this medicine after having high blood pressure for 9 months. The first pill made me nauseous and dizzy. I was told that my body would get used to it. Seven days later, I have pain in my stomach and right lower side, severely nauseous, dizzy like being drunk, and I am a Type 2 diabetic. My blood sugar spiked 65%! I took my last pill on a Sunday, telehealth visit with the doctor on Monday, and was taken off this medication. It took me until Friday and 2 Imodium to get rid of the side effects."

1 / 10
Was this helpful?YesNo
18 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • sup...
  • February 20, 2016

For High Blood Pressure "This med was added to enhance my present ACE inhibitor (Enalapril 20 mg/2x daily) to reduce my BP. Recently, I became extremely ill with a viral sinus infection, and ultimately my BP spiked because of fighting this wicked infection. The physician thought it may be prudent to lower the BP, so HCTZ was added to the regimen of treatment at 25 mg per day. I've been on it for 3 weeks. BP is normal, but it was normal before the infection on Enalapril. I am in good health, eat right, and exercise. I can't believe the side effects: extreme fatigue, nausea, gastric pains, muscle pains, weakness, anxiety, and on and on. I contacted the physician today, and she immediately removed me from the med. Be careful and be watchful if this med!!"

1 / 10
Was this helpful?YesNo
53 Report
  • Lac...
  • Taken for less than 1 month
  • August 9, 2016

For High Blood Pressure "I started taking this medicine 4 days ago. On day 3, the cramps started so badly that I couldn't do anything without my hands involuntarily becoming fists, sometimes both of them, to the point of my husband having to help me pry them apart. I also had dizziness, nausea, muscle pain, among others. None of which I had on the Benazapril. I talked to my doctor yesterday, and he switched me to something different. I'm hoping it helps!"

1 / 10
Was this helpful?YesNo
50 Report
  • Luc...
  • August 12, 2017

For High Blood Pressure "I have been on 25 mg once daily of this medication for over 20 years now. I take it with Losartan (beta blocker). I have never experienced any of the side effects (e.g., dry mouth, dizziness, nausea, etc.) that others have reported here. Of course, it's a diuretic, so frequent urination (another side effect others report) is going to occur. But for myself, I've not noticed it, as the only time I experienced frequent urination was due to either a UTI or the massive fibroids that formerly pressed on my bladder; the HZT never contributed to this. So really, I've never had one side effect that I could attribute to this drug at all since I began taking it. In fact, the only warning from the pharmacy is to avoid sunlight or artificial sunlight."

10 / 10
Was this helpful?YesNo
29 Report
  • Min...
  • June 2, 2010

For High Blood Pressure "I originally gave this medicine a thumbs down, as the side effects, nausea and leg cramps, were too much. Decided to try it again at the prompting of my doctor, and after a few days, adjusted to it. 25 mg dosage, the edema is gone, and it seems to work with my beta blocker, with no issues."

8 / 10
Was this helpful?YesNo
42 Report
  • mch...
  • Taken for less than 1 month
  • February 22, 2015

For High Blood Pressure "Side effects: extreme dry mouth, nausea."

1 / 10
Was this helpful?YesNo
27 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.