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Hyaluronidase and Pain: What Users Say

Brand names: Hylenex, Vitrase, Amphadase, Hydase

Pain: mentioned by 7 users (9.3%)

Based on user experiences from 75 Hyaluronidase reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 18.7%
skin issues 12.0%
dry eyes 10.7%
pain 9.3%
swelling 8.0%
nerve damage 6.7%
blurred vision 5.3%
bruising 5.3%
tight skin 5.3%
hair loss 4.0%

Reviews for Hyaluronidase

Commonly mentioned side effects
  • Ano...
  • Taken for less than 1 month
  • June 11, 2021

For Dissolution of Dermal Filler "I had Hyaluronidase injections used on my face to dissolve filler, and it has caused nerve damage, pain, and burning sensation. I experienced dry eyes, blurred vision, and it damaged my skin permanently. I have experienced volume loss, skin laxity, sunken eyes, changes in skin texture, and pain in the left side of my jaw. I am unable to open my mouth properly because my jaw clicks and locks. I had the injection over a year ago, never had any of these problems before, and it is still ongoing. It was an awful experience."

1 / 10
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137 Report
  • Ano...
  • Taken for less than 1 month
  • June 11, 2021

For Dissolution of Dermal Filler "I had Hyaluronidase injections used on my face to dissolve filler, and it has caused nerve damage, pain, and burning sensation. I experienced dry eyes, blurred vision, and it damaged my skin permanently. I have experienced volume loss, skin laxity, sunken eyes, changes in skin texture, and pain in the left side of my jaw. I am unable to open my mouth properly because my jaw clicks and locks. I had the injection over a year ago, never had any of these problems before, and it is still ongoing. It was an awful experience."

1 / 10
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137 Report
  • Evi...
  • November 13, 2021

For Dissolution of Dermal Filler "This was used to remove filler. I am three months out since it was used. Affected my whole face. Eyes destroyed with non-functional tear ducts. Some days I'm not able to open them due to pain. Upper lids dried out causing more severe pain. Lower eyelids are kind of no longer attached to eyes. The whole body burning and the pain makes me vomit on a daily basis. Wounds won't heal anymore and bruises don't go away. Oculists and doctors don't take you seriously - don't you ever believe you will get any help wherever in the world you live. This substance easily steals your life away and from then you are alone. Don't you ever use this substance. Don't do it. Please, wait for the filler to dissolve on its own. Now I have told you."

1 / 10
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68 Report

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Frequently asked questions

  • Anonymous
  • Taken for 1 to 6 months
  • August 2, 2021

For Dissolution of Dermal Filler "Had 1 nasolabial dissolved. Destroyed my connective tissue. Have been going to therapy. Refilled but not the same. Dent in my face. I will never be the same again. I take vitamins and see an esthetician. The cosmetic community has let me down. They told me nothing bad would happen and not to believe reviews. I have regretted this every day. I don’t know how I will make it through. I am devastated. This drug should be illegal except for emergencies. It makes me wonder what else I’m lied to about. It caused saggy skin and premature aging. Protect your skin. This has ruined me & caused great pain."

1 / 10
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67 Report
  • Joe...
  • April 22, 2021

Hyaluronidase "It has been 4 months since Vitrase destroyed a part of me. I was not told any of the risks associated with its use, other than maybe volume loss, that's it. Why are these injectors getting away with this? Why do criminals have more rights than a damaged patient? I have corneal inflammation from it. Pain, itchy eyes, and it's a living nightmare. Not even mentioning what it did to my face, it completely destroyed it."

1 / 10
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59 Report

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  • Dam...
  • Taken for 1 to 6 months
  • September 3, 2022

For Dissolution of Dermal Filler "Hyaluronidase to dissolve filler is an off-label use of the drug. Dissolver can and does impact your own skin tissue and can cause long-term serious issues. I had my upper lip dissolved 4.5 months ago and have been dealing with tingling and pain all over my chin and jaw ever since. Every day I wake up with new dents on my face where my actual skin tissue has been eaten by the drug. It’s the biggest regret of my life so far. Just want to make sure nobody else makes the same mistake as me."

1 / 10
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30 Report
  • Che...
  • December 28, 2022

For Dissolution of Dermal Filler "I had hyaluronidase a week ago. Worse experience of my life. On the left side of my face, I have hollowing of the eye. On the right side, it is puffy and sticks out very badly. Plus, I have bruising and pain. I immediately knew after 3 days the procedure was done incorrectly. The company is supposed to have 14 years of experience. I had to reach out to another company who came out of hours to look, they said it'd been done incorrectly. I'm going there Friday to correct the work done the week before. I now have to start the process again. It's caused anxiety and also pain in other areas. I will never have fillers again for this to happen, disturbing all the young people and filling their faces, they will regret it over the next few years. As they age, skin stretches and gets loose. I will never put myself through that again. No to fillers. They are not safe, I now have to live with the damage."

3 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.