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Hyaluronidase and Joint Pain: What Users Say

Brand names: Hylenex, Amphadase, Vitrase Hydase

Joint pain: mentioned by 4 users (5.2%)

Based on user experiences from 77 Hyaluronidase reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 19.5%
skin issues 11.7%
dry eyes 10.4%
pain 9.1%
swelling 7.8%
nerve damage 6.5%
blurred vision 5.2%
bruising 5.2%
hair loss 5.2%
joint pain 5.2%

Reviews for Hyaluronidase

  • PAE...
  • November 5, 2021

Hyaluronidase "I was told by my doctors that it would not spread and it does not damage tissue. It did both. From injections around my mouth to my eyes, scalp, hands, feet... I was scared for my vision at one point. Six months out and this has been a living nightmare. I can’t believe the FDA is allowing this to happen to so many women. Most may not relate it to the dissolver... like joint problems, dry eye, etc. Manufacturers should have a warning label like Botox."

1 / 10
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32 Report
  • Ptt...
  • Taken for less than 1 month
  • June 6, 2022

For Dissolution of Dermal Filler "I was injected with 2 full undiluted syringes to dissolve undereye filler. The dermatologist explained to me she does this all the time with no issues. Needless to say, I was in the ER that week. The months following were horrific. Night sweats, hallucinations, gums receding and teeth numbness, nerve damage, constant blood in my nose, eyesight burning which spread from my undereyes all the way through my cheeks, then ears, then neck, then hands and legs, and what looks like feet at month 4-6. Fat became jellylike. At month 4, I had a reaction from something I ate, the whole inside of my nose and around burned and scabbed up. I'm 6 months in, and the systemic issues are out of this world. Constant infections, hair falling out, eyelash loss, cartilage changes in nose and ears, skin on the whole body is becoming loose. Joint pain, head pressure, etc., etc., etc."

1 / 10
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26 Report
  • Anonymous
  • Taken for 1 to 2 years
  • March 24, 2023

For Dissolution of Dermal Filler "Hyaluronidase destroyed my life. After taking hyaluronidase, my face lost volume and the face changed shape. My eyes felt like they had sunken into the socket, the skin on my face and my body changed and became thin and spongy, and my joints cracked and hurt, and my vision is now bad, and I have lost all my hair."

1 / 10
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7 Report

Frequently asked questions

  • Ano...
  • Taken for 5 to 10 years
  • September 4, 2025

"A few weeks after being injected with hyaluronidase, I started having the following symptoms: thinning, crepey, translucent skin, mushy muscles, loss of volume in hands, feet, and knees, a burning sensation all over my body, joint pain, varicose veins, and spider veins. I was terrified, seeing my body changing every day and being in constant pain. I spent all my savings trying to find a treatment. The only thing that helped with the pain and burning was a carnivore diet. No improvements on everything else. I was afterward diagnosed with osteopenia and lymphedema. Nobody in my family had these illnesses, and I am only 41. My life has been destroyed by these injections, the doctors who inject them are criminals and they should pay. My body has been abused by this industry and nobody seems to be kept responsible. My life ended at 35 when I had these injections."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.