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Hyaluronidase and Swelling: What Users Say

Brand names: Hylenex, Vitrase, Amphadase, Hydase

Swelling: mentioned by 6 users (8.0%)

Based on user experiences from 75 Hyaluronidase reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 18.7%
skin issues 12.0%
dry eyes 10.7%
pain 9.3%
swelling 8.0%
nerve damage 6.7%
blurred vision 5.3%
bruising 5.3%
tight skin 5.3%
hair loss 4.0%

Reviews for Hyaluronidase

Commonly mentioned side effects
  • Unf...
  • June 22, 2022

For Dissolution of Dermal Filler "Not denying that this works, I will state that it is unpredictable and uncontrollable. I used this 1 year ago and was perfectly fine after a few days of swelling. 1 year later, however, I used the ‘magic eraser’ after an overfill, and this drug has completely ruined my life. My eyes have sunken into my skull and changed shape, my forehead forms ripples when I run my finger along it, I can literally lift my cheeks up and down, and my jawline is saggy. This also caused my hair to fall out, and I lost collagen in not only my face but my whole body. I am currently seeking surgery to rectify the horrific damage to my face. My face has aged 30 years, and I have lost all of my features. I am only 30 years old, by the way, from an outgoing, confident girl to someone who would rather hide in their room. If I had known this was even a possibility, I would have kept the botched filler for the rest of my life. This is the biggest mistake I have ever made, and I wish someone had told me this was a risk beforehand."

1 / 10
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40 Report
  • Cla...
  • October 1, 2021

For Dissolution of Dermal Filler "I had filler, one eye was overfilled. I lived with it for about 4 months, eventually decided to get it dissolved because it kept puffing up and looking worse. The hyaluronidase definitely did its job and some. There was an unmistakable dent. I had the dent refilled, but the skin looked wrinkly. After a few weeks, all swelling has settled, there is still a small indent that I’m considering getting a tiny bit more filler to level it out. I was told any mistake with filler would be “easily resolved.” The same doctor then told me, “I would be opening a can of worms,” when I inquired about dissolving it. Anyway, what I wanted to do was let anyone who reads this know that glycolic acid really helped my skin plump back up. I’ve been using the Made By Sunday one called Recovery, but I’m sure others would work just as well. I hope this works for someone else as it’s really helped me. I’ve been using it for a week, and my skin looks completely different."

3 / 10
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46 Report
  • ACM...
  • Taken for less than 1 month
  • March 27, 2022

For Dissolution of Dermal Filler "I recently had filler excess dissolved from under my eyes. I took initial swelling and discoloration as due to the lidocaine mixed in, but am wondering if it was another side effect from hyaluronidase. I am very sad to say I truly regret having this injected. It's been about 45 days, and my under-eyes are not only sunk in at the outer corners, but I also have huge bags as if they were herniated due to the loss of connective tissue. I had my 2-week follow-up appointment, and we were happy with the dissolving results, except that it kept dissolving. Another 2 weeks, and I returned for a refill and mentioned the bags. I think what hurt me the most was how the injector completely dismissed me and implied that I probably did something to my eyes as they looked so different than the last visit. Regardless, as so many other women here, I am now on a quest to find a solution. It's very unfortunate that injectors and doctors use this drug all the time without understanding how terrible it can be."

2 / 10
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25 Report

Frequently asked questions

  • Bam...
  • Taken for 1 to 6 months
  • September 18, 2022

For Dissolution of Dermal Filler "I had a full vial of Hyalase injected to dissolve 1.5 ml of filler. Less than 2 months later, it caused my temples to sink in and hollow. It has also sunken in my cheeks and resulted in stretchy skin. Other, more mild side effects include blurred vision and thin skin that sags, hollowing of eyes, and pitting edema. Do NOT ever risk using this product, the effects are highly unpredictable. I feel as though it has resulted in rapid aging within months. I’ve been researching, and many people have experienced ongoing deformation of their faces for up to 3 years. I am so afraid it will cause my face to collapse, and I wouldn’t want anyone else to experience this. The product is NOT TGA or FDA approved for aesthetic use. Instead, it is used off the shelf when it comes to dissolving filler. Hyaluronidase is also known to play a role in cancer. It’s simply a dangerous product, and its current use is entirely irresponsible and should be made illegal for use in cosmetics."

1 / 10
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12 Report
  • Sar...
  • Taken for less than 1 month
  • April 2, 2022

For Dissolution of Dermal Filler "Shocked at so many scary reviews and sad for people’s negative experiences. I personally have had hyaluronidase for filler dissolving on around 6 different occasions over 4 years for lip, chin, jaw dissolving with no issues at all. Had tiny swelling, minimal bruising which went away within a few days to a week maximum. Also went to different injectors for dissolving with the same results. Noticed no difference in my skin's elasticity, texture, etc., apart from with lips, but they then went back to normal after a few days. I was patch tested each time and only proceeded following no reaction after around 20 minutes."

10 / 10
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23 Report
  • Mel...
  • Taken for 6 months to 1 year
  • August 22, 2021

For Dissolution of Dermal Filler "I had hyaluronidase under my eyes to help remove filler under my eye. Well, my eyes swelled up, almost shut for 6 months. The lady told me I was allergic to it. Be very careful."

1 / 10
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13 Report

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