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Hyaluronidase Dosage

Medically reviewed on August 16, 2018.

Applies to the following strengths: 150 units; 1500 units; 150 units/mL; 200 units/mL; 6200 units

Usual Adult Dose for Hypodermoclysis

After inserting the needle, begin clysis with tip of needle lying free and movable between the skin and muscle. The fluid should start in readily without pain or lump. Then hyaluronidase should be injected into the rubber tubing close to the needle.

Alternate method: Inject hyaluronidase under skin before clysis. 150 to 200 units will facilitate absorption of 1000 mL or more of solution.

Comments:
-The dose, rate of injection, and type of solution should be individualized; rate of infusion and volume of administration should not exceed those used for intravenous infusion.
-Hypovolemia may occur if electrolyte-free solutions are given.
-Adding adequate quantities of electrolytes and/or controlling the volume and rate of administration will prevent hypovolemia.


Use: As an adjuvant in subcutaneous fluid administration (hypodermoclysis) for achieving hydration

Usual Adult Dose for Subcutaneous Urography

With the patient prone, inject 75 Units subcutaneously over each scapula, followed by injection of contrast medium at the same sites

Use: As an adjuvant in subcutaneous urography for improving resorption of radiopaque agents

Usual Pediatric Dose for Hypodermoclysis

After inserting the needle, begin clysis with tip of needle lying free and movable between the skin and muscle. The fluid should start in readily without pain or lump. Then hyaluronidase should be injected into the rubber tubing close to the needle.

Alternate method: Inject hyaluronidase under skin before clysis. 150 to 200 units will facilitate absorption of 1000 mL or more of solution.

Under 3 years of age:
-Limit the volume of a single clysis to 200 mL

Premature Infants or During the Neonatal Period:
Maximum daily dosage: 25 mL/kg of body weight
Maximum rate of administration: 2 mL/minute

Comments:
-The dose, rate of injection, and type of solution should be individualized; rate of infusion and volume of administration should not exceed those used for intravenous infusion.
-Hypovolemia may occur if electrolyte-free solutions are given.
-Adding adequate quantities of electrolytes and/or controlling the volume and rate of administration will prevent hypovolemia.


Use: As an adjuvant in subcutaneous fluid administration (hypodermoclysis) for achieving hydration

Usual Pediatric Dose for Subcutaneous Urography

With the patient prone, inject 75 Units subcutaneously over each scapula, followed by injection of contrast medium at the same sites

Use: As an adjuvant in subcutaneous urography for improving resorption of radiopaque agents

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to any of the ingredients

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Do not give intravenously
-For infiltration, interstitial, intramuscular, intraocular, peribulbar, retrobulbar, soft tissue, or subcutaneous use.

Storage requirements:
-Refrigerate; do not freeze
-Protect from light

IV compatibility:
-Check appropriate references for physical or chemical incompatibilities.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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